Navigation Links
Pandemic flu, like seasonal H1N1, shows signs of resisting Tamiflu
Date:3/1/2010

nies said. "We can see it happening already.

"This has potential to indicate that we are going to have to think of something else to use to treat pandemic H1N1 influenza."

The same study showed that resistance to a second antiviral drug zanamivir, known by the brand name Relenza is not as prevalent, suggesting this medication might be a good alternative to Tamiflu, he said.

The research appears online in the International Journal of Health Geographics.

So far, most pandemic H1N1 strains that have been isolated from humans are susceptible to Tamiflu. As of Feb. 3, 2010, 225 cases of pandemic H1N1 were reported to be resistant to the drug out of the predicted millions of cases of illnesses with swine flu across the United States and elsewhere in the world.

But those resistant cases, as well as the way mutations have led to Tamiflu resistance in seasonal H1N1, offer clues about how the virus changes itself to survive against the popular drug.

The two types of H1N1 virus, seasonal and pandemic, are similar on the surface, where their proteins interact with cells in the human body. But the internal genes of the viruses are configured differently.

The researchers zeroed in on specific points in the neuraminidase protein this protein is what the "N" refers to in these virus subtype names. Resistance to oseltamivir in H1N1 can evolve as a result of a point mutation at one of several locations on this protein, Janies said.

He and colleagues analyzed mutations in neuraminidase proteins from 1,210 seasonal H1N1 viruses isolated around the world between September 2004 and December 2009. For pandemic H1N1, the researchers examined mutations in specific points on neuraminidase proteins of 1,824 viruses collected between March 2009 and December 2009.

"With the rapid availability of public sequence data on pandemic influenza, we are able to essentially watch evolution in real time," Janies
'/>"/>

Contact: Daniel Janies
daniel.janies@osumc.edu
614-292-1202
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness
2. CEO Addresses Tennessee Business Leaders About Developing Pandemic and Business Continuity Plans
3. Peer-Reviewed, Online Database Showcases Local, County and State Pandemic Planning
4. New Report Says a Pandemic is Overdue, But Companies and Nations are ill Prepared to Cope With the Impact
5. Report highlights inadequate pandemic planning as a threat to EU security
6. AIDS Ignorance: One-Third of Adults Admit Little or No Knowledge of Pandemic
7. Global Summit on AIDS & The Church Calls for Public, Private and Parish Sectors To Unite in Response to Worldwide Pandemic: Pastor Rick and Kay Warren Host More Than 1,700 at Event Featuring International Dignitaries, Political Figures and International E
8. Vical Expands Clinical Testing of DNA Vaccine Against H5N1 Pandemic Influenza
9. CEO Addresses Georgia Business Leaders About Developing Pandemic and Business Continuity Plans
10. iJET Unveils 2007 Year-in-Review Report on Avian Influenza and Pandemic Planning
11. Flu Pandemic: Is the U.S. Ready?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... A new medical-testing device is being prepped to ... could improve diagnosis of certain diseases in remote ... a series of investigations aboard the International Space ... uses the space-tested concept of capillary flow to ... , David Kelso, Ph.D., a researcher at Northwestern ...
(Date:4/18/2014)... did it make you feel? According to psychologists, remembering ... as how sad you were or how embarrassed you ... can,t stop thinking about it. , When these ... the memories, rather than how you felt, is a ... effects of these memories, a new study suggests. , ...
(Date:4/18/2014)... French . ... regenerative medicine. A team led by Ludwik Leibler from ... and Didier Letourneur from the Laboratoire Recherche Vasculaire Translationnelle ... that the principle of adhesion by aqueous solutions of ... organs and tissues. This easy-to-use gluing method has been ...
(Date:4/17/2014)... variant specifically associated with the risk of a ... cent of all breast cancer cases. , The ... called invasive lobular carcinoma, gives researchers important clues ... of breast cancer, which can be missed through ... the journal PloS Genetics , was co-led ...
(Date:4/17/2014)... April issue of Experimental Biology and Medicine ... Rex Gaskins and Paul Kenis in the Institute ... the University of Illinois Urbana-Champaign describe their recent ... underlie a variety of cell functions including energy ... crucial roles in regulating normal cellular behavior, redox ...
Breaking Medicine News(10 mins):Health News:Space-tested fluid flow concept advances infectious disease diagnoses 2Health News:Space-tested fluid flow concept advances infectious disease diagnoses 3Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2
... , MONDAY, March 14 (HealthDay News) -- Women may ... a diet rich in two types of B vitamins, a ... and riboflavin (B2) in their food significantly reduced their risk ... fortified cereals, whole grains, beans and nuts, and researchers said ...
... By Jenifer Goodwin HealthDay Reporter , MONDAY, March ... that is, a pediatrician or nurse they see regularly who offers ... dental needs met, new research finds. Yet it,s the sickest ... and require the most care -- who are less likely to ...
... the globe are making headway in fighting communicable diseases ... research from the Frederick S. Pardee Center for International ... School of International Studies. The center ... volumes that focus on human progress in which researchers ...
... human studies of an oral drug regimen to prevent HIV ... in HIV incidence, but a number of issues require additional ... a large scale, according to an article in AIDS ... Mary Ann Liebert, Inc. ( www.liebertpub.com ). The article is ...
... Research and Education recently received a five year, $3.7 ... and Agriculture to fund a project aimed at preventing ... to teach mothers simple yet authoritative strategies to promote ... The grant was awarded to Jenifer Orlet Fisher, associate ...
... ,Scientists at the National Institute of Allergy and Infectious ... have shown how the O157:H7 strain of Escherichia ... host immune response. The bacterium secretes a protein called ... alter specific immune responses. This process not only helps ...
Cached Medicine News:Health News:Diets Rich in Vitamin B May Help Prevent PMS, Study Finds 2Health News:'Medical Homes' Help Kids Get Comprehensive Care 2Health News:'Medical Homes' Help Kids Get Comprehensive Care 3Health News:DU researchers find that headway being made fighting communicable diseases globally 2Health News:DU researchers find that headway being made fighting communicable diseases globally 3Health News:Early success of anti-HIV preventive oral drug regimen is promising, but questions remain 2Health News:Temple receives $3.7 million to study parenting styles' effect on childhood obesity 2
(Date:1/14/2014)... HeartWare International, Inc . (NASDAQ: HTWR ... support technologies that are revolutionizing the treatment of advanced ... the fourth quarter of 2013 will be approximately $53 ... million. "Our full-year revenue growth of 87% ...
(Date:1/14/2014)... 2014 The Brandeis Medical Center, led by Dr. Emmanuel ... and affordable laser tattoo removal experience with the advanced Astanza Duality ... providing high quality cosmetic services with cutting edge medical technology and ... Southern California has seen a dramatic increase in the ...
(Date:1/14/2014)... Emergency Critical Care, a LifeCentre partner practice, located at 165 Fort ... first in Loudoun County to receive a ... M. Barnes , Medical Director, is a well-seasoned veterinarian of more ... , are avid scuba divers. "As altitude skiers and hikers, we ...
Breaking Medicine Technology:HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2
... Application Enables Collaboration by Connecting SciVerse ... , Elsevier , a world-leading provider of scientific, technical ... of an expert identification and discovery application that connects ... and research synthesis, with the DIRECT2Experts online ...
... 14, 2012  Organovo Holdings, Inc. (OTCQB: ONVO) ("Organovo") ... on February 8, 2012, with Organovo, Inc. (the ... three-dimensional bioprinting technology for research and medical applications.  ... placement consisting of approximately 6.5 million units of ...
Cached Medicine Technology:Elsevier Introduces Expert Discovery Application for SciVerse Hub 2Elsevier Introduces Expert Discovery Application for SciVerse Hub 3Elsevier Introduces Expert Discovery Application for SciVerse Hub 4Organovo Announces $6.5 Million Private Placement to Advance 3D Bioprinting for Medical Applications 2Organovo Announces $6.5 Million Private Placement to Advance 3D Bioprinting for Medical Applications 3
Baby Weitlaner retractor, blunt, 4"....
Bruns (Volkmann) bone curette, with Novotex plastic handle (autoclavable in autoclave up to 143C by 3 bar), 9, oval....
15" overall length, 5" handle....
15" overall length, 9" handle....
Medicine Products: