Navigation Links
Pancreatic cancer study reveals mechanism initiating disease, in mice
Date:3/12/2010

s.

"These results indicate that beta-catenin is essential for acinar regeneration," says Hebrok, a member of the UCSF Helen Diller Comprehensive Cancer Center. "They also demonstrate that beta-catenin signaling must be blocked in order for mutant Kras to exploit the plasticity of cell fate that arises during pancreatic damage and to force these de-differentiated cells to become PDA precursors."

In the absence of injury, he says, "a mutation in Kras in an acinar cell likely would not cause the cell to undergo changes leading toward cancer, or it might cause these changes at a very slow rate. But if there is a mutation in Kras in a cell that has become de-differentiated in response to acute or chronic pancreatitis, this progression toward cancer would occur relatively quickly."

The finding, he says, illuminates the fine line between regeneration and carcinogenesis in the body's cells. "Cellular plasticity is necessary to allow damaged cells to activate their embryonic programs and temporarily activate embryonic signaling pathways to regenerate themselves," says Hebrok. "But cells also need to be able to turn off these signaling pathways."

"Our study underlines the likelihood that not only must mutations be acquired in a specific sequence in order to develop PDA, but levels of developmental signaling pathways must be tightly regulated to alter normal cellular plasticity and drive neoplastic cell fates."

The finding also reveals a new role of beta catenin in cancer. While the beta catenin and KRAS proteins appear to oppose one another during tumor initiation in PDA, they work together in several types of established tumors, including later stages of pancreatic cancer.


'/>"/>

Contact: Jennifer OBrien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Pancreatic Cancer Study Reveals Mechanism Initiating Disease, In Mice
2. New Treatment Eyed for Deadly Pancreatic Cancer
3. New tool developed to help guide pancreatic cyst treatment
4. Mayo Clinic researchers find oncogene is important in pancreatic cancer growth and spread
5. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
6. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
7. Soft drinks may increase risk of pancreatic cancer
8. Soft Drinks Could Boost Pancreatic Cancer Risk
9. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
10. Scientists show how molecular switch helps pancreatic cancer beat drugs
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... Atlantic NeuroSurgical Specialists (ANS) brain tumor support ... their strides in their fight against brain cancer. The event ... Morristown office. , The annual BBQ has grown remarkably in ... where patients can find love, hope and support from their ... were enjoyed by guests, including a dunk tank where patients ...
(Date:9/29/2014)... NY (PRWEB) September 30, 2014 ... a 2014 Professional Woman of the Year. She is ... As the largest networking organization of professional women in ... a powerfully vibrant networking community with over 600,000 members ... food service management, I made a right about turn ...
(Date:9/29/2014)... Garden City, NY (PRWEB) September 30, 2014 ... Marriage and Family Therapist at Heaven Sent ... Year. Ms. Ross is recognized with this prestigious distinction ... largest, most-recognized networking organization of professional women in the ... Association of Professional Women is a powerfully vibrant networking ...
(Date:9/29/2014)... September 30, 2014 NAPW ... Manager Specialist, as a 2014 Professional Woman of the ... for leadership in clinical care. As the largest networking ... every industry and profession, the National Association of Professional ... 600,000 members and nearly 300 Local Chapters. , Sarah ...
(Date:9/29/2014)... NAPW honors Rachel L. ... as a 2014 Professional Woman of the Year. She ... home health services. As the largest, most-recognized organization of ... profession, the National Association of Professional Women (NAPW) is ... and nearly 300 Local Chapters. , As co-founder of ...
Breaking Medicine News(10 mins):Health News:Local Brain Tumor Foundation, ANS Center of Hope, Celebrates its Brain Cancer Patients 2Health News:National Association of Professional Women Announces Hope H. Anderson, President of Hope Nutritional Services, a 2014 Professional Woman of the Year 2Health News:National Association of Professional Women Announces Carmel T. Ross, Marriage and Family Therapist at Heaven Sent Consultation, a 2014 Professional Woman of the Year 2Health News:National Association of Professional Women Announces Sarah Shiermeister, Clinical Manager Specialist at Gentiva Health Services, a 2014 Professional Woman of the Year 2Health News:National Association of Professional Women Announces Rachel L. Gregus, Co-Founder of Safe Hands Warm Hearts, Inc., a 2014 Professional Woman of the Year 2
... the onion have antioxidant and antimicrobial properties, making it possible ... by researchers from the Polytechnic University of Catalua (UPC) and ... just been published in the International Journal of Food ... of the flavonoids of the raw onion make it a ...
... -- Researchers from the Sackler Center at Weill Cornell Medical College ... master regulatory protein responsible for causing the most common type of ... Findings published in today,s issue of Cancer Cell show ... Weill Cornell Medical College, the University of Maryland and the Ontario ...
... ... ... 18th annual Leadership Summit being presented by Health Forum and ... focus on the organizational characteristics, structures, and processes that will lead to a high-performing ...
... policies may explain the connection , WEDNESDAY, April 14 ... nicotine dependence, finds a study that contradicts the popular ... German researchers used an internationally recognized and validated nicotine ... employed participants in the Cologne Smoking Study. , The ...
... ... magnitude 6.9 earthquake that has rocked Western China. , ... Lakewood Ranch, FL (Vocus) April 14, 2010 -- ... rocked Western China., , , , ,The earthquake struck the remote and mountainous Qinghai ...
... Scientists in Alaska have discovered that lingering oil from the ... wildlife more than 20 years after the disaster. The research, ... to reveal long-term exposure to oil in harlequin ducks and ... rather than years. The Exxon Valdez tanker ran aground ...
Cached Medicine News:Health News:The onion, a natural alternative to artificial preservatives 2Health News:New class of drug kills lymphoma cells 2Health News:Health Forum / American Hospital Association 2010 Leadership Summit 2Health News:ShelterBox Responds to Earthquake in Western China 2Health News:Wildlife still exposed to Exxon Valdez oil 20 years after disaster 2
(Date:9/29/2014)... , Sept. 29, 2014  ADM Tronics ... it has entered into an affiliation with Triotech ... Cambridge, Massachusetts founded by ... member of ADMT,s Advisory Board. The ... technology companies with specialized services and finances to ...
(Date:9/29/2014)...  Diplomat, the nation,s largest independent specialty pharmacy, ... named chief information officer. As CIO, Brown will ... department while being responsible for strategic planning, data ... Prior to joining Diplomat, Brown served ... of technology architectures and organizational solutions, new client ...
(Date:9/29/2014)... 29, 2014 Novogen Ltd. (ASX: NRT, NASDAQ: ... , conducted an interview with ABC TV that was broadcast ... bulletin and on the following day on Weekend Breakfast. The ... Trilexium, into the clinic in Australia ... multiforme. The interview provides certain new information ...
Breaking Medicine Technology:ADM Tronics Joins Triotech Ventures Technology Consortium 2ADM Tronics Joins Triotech Ventures Technology Consortium 3Diplomat names Stephen S. Brown chief information officer 2ABC TV Interview Discusses the Potential of Trilexium(TM) to Treat Brain Cancer 2ABC TV Interview Discusses the Potential of Trilexium(TM) to Treat Brain Cancer 3
... AUSTIN, Texas, May 24, 2011 A paper published ... demonstrated that adding OVA1 to a physician,s preoperative ... ovarian cancers than a physician,s preoperative assessment alone. The ... the journal, which is the official publication of the ...
... Holdings, Inc. (OTCQB: ABHI), a leader in the development of ... has signed a new line of credit with East West ... to expire July 2011. The new line of credit expands ... the previous revolving line and extends the line by one ...
Cached Medicine Technology:OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment 2OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment 3OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment 4AmbiCom Renews and Expands Line of Credit With East West Bank 2AmbiCom Renews and Expands Line of Credit With East West Bank 3
... for the precise requirements of blood ... Blood Bank Equipment meets American Association ... Red Cross (ANRC) and U.S. Food ... storage freezers, and platelet incubators feature ...
... small bench style refrigerator (can be situated on ... number of bags is to be stored as ... is white colorbond steel while the interior is ... glass door is key lockable. Control panel is ...
... This refrigerator is ... storage of blood in ... with Australian Standard AS3864 ... is air-cooled utilising CFC ...
The Testosterone Enzyme Immunoassay is intended for the quantitative determination of Testosterone concentration in human serum. No special pretreatment of the sample is necessary. For in vitro Diag...
Medicine Products: