Navigation Links
Pancreatic cancer study reveals mechanism initiating disease, in mice
Date:3/12/2010

UCSF scientists have discovered how a mutated gene known as Kras is able to hijack mouse cells damaged by acute pancreatitis, putting them on the path to becoming pancreatic cancer cells.

The finding, they say, suggests one way in which the mutated gene -- found in nearly all cases of the most common and lethal form of pancreatic cancer -- exacts its toll in humans. It also strengthens evidence that chronic pancreatitis, which occurs when digestive enzymes become activated too soon, causing abdominal pain, indigestion and other symptoms, may be a risk factor in the development of pancreatic cancer, rather than a side effect.

The finding, says senior author Matthias Hebrok, PhD, the Hurlbut-Johnson Distinguished Professor in Diabetes Research and interim director of the UCSF Diabetes Center, could help scientists in their search for diagnostic markers in the blood of pancreatic cancer, as well as targets for therapy.

While evidence from patient tissue and mouse studies has indicated that pancreatic ductal adenocarcinoma (PDA) evolves from cells known as ductal cells -- which line the ducts through which digestive enzymes are transported from the pancreas to the small intestine -- recent studies by other labs have shown that PDA can emerge from so-called acinar cells, which produce digestive enzymes.

Subsequently, scientists in other labs have confirmed that mutated Kras can initiate the development of precursors to PDA in acinar cells. However, the findings have been puzzling, because expression of mutated Kras does not guarantee acinar reprogramming.

Given this inconsistency, scientists have hypothesized that other events in the cellular environment must occur for mutated Kras to assert itself, and recent studies have indicated that acute and chronic pancreatitis may be one such factor. When mutant Kras is active in the acinar cells of mice with chemically-induced acute pancreatitis, the development of precursors
'/>"/>

Contact: Jennifer OBrien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Pancreatic Cancer Study Reveals Mechanism Initiating Disease, In Mice
2. New Treatment Eyed for Deadly Pancreatic Cancer
3. New tool developed to help guide pancreatic cyst treatment
4. Mayo Clinic researchers find oncogene is important in pancreatic cancer growth and spread
5. News brief: ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma
6. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
7. Soft drinks may increase risk of pancreatic cancer
8. Soft Drinks Could Boost Pancreatic Cancer Risk
9. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
10. Scientists show how molecular switch helps pancreatic cancer beat drugs
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... 22, 2013 Cedars-Sinai Heart Institute is honoring ... pioneer in modern mitral heart valve repair, Alain ... Corday, MD, International Prize in Heart Research. The ... recognize physicians and scientists conducting groundbreaking research, or ... medicine. , Carpentier is a leading ...
(Date:5/22/2013)... A new study provides neurobiological evidence for ... in people with insomnia, which may have implications ... , "Insomnia has been consistently identified as a ... Franzen, PhD, an assistant professor of psychiatry at ... in the brain circuitry underlying emotion regulation may ...
(Date:5/22/2013)... May 22, 2013 Digital Advertising Agency, ... behalf of its social media management client, Primal ... year's supply of the all-natural organic deodorant. The contest ... of the rapidly-growing start-up deodorant company based in Tampa, ... contest or sweepstakes on a Facebook page is a ...
(Date:5/22/2013)... (PRWEB) May 22, 2013 DiscountFurnaceFilter.com ... quality merchandise ranging from furnace filters, dehumidifiers, fans, ... is excited to add Stadler Form's product line ... summer product line (fans, aroma diffusers and dehumidifiers) ... Form’s Otto Fan is the perfect combination of ...
(Date:5/22/2013)... York, NY and Troy, NY (PRWEB) May 22, ... Medicine at Mount Sinai and Rensselaer Polytechnic Institute ... educational programs, research, and development of new diagnostic ... alliance was commemorated in a signing ceremony on ... initiative to use their expertise—Rensselaer’s in engineering and ...
Breaking Medicine News(10 mins):Health News:Heart valve repair innovator receives Cedars-Sinai Heart Institute's Corday Prize in Heart Research 2Health News:Study shows that insomnia may cause dysfunction in emotional brain circuitry 2Health News:Social Media Management Firm, 21Digital, Launches National Facebook Sweepstakes for Client, Primal Pit Paste 2Health News:DiscountFurnaceFilter.com Now Offers Stadler Form Products - Providing Solutions to All Your Summer Needs 2Health News:Icahn School of Medicine at Mount Sinai and Rensselaer Polytechnic Institute Announce Academic Collaboration 2Health News:Icahn School of Medicine at Mount Sinai and Rensselaer Polytechnic Institute Announce Academic Collaboration 3Health News:Icahn School of Medicine at Mount Sinai and Rensselaer Polytechnic Institute Announce Academic Collaboration 4Health News:Icahn School of Medicine at Mount Sinai and Rensselaer Polytechnic Institute Announce Academic Collaboration 5Health News:Icahn School of Medicine at Mount Sinai and Rensselaer Polytechnic Institute Announce Academic Collaboration 6Health News:Icahn School of Medicine at Mount Sinai and Rensselaer Polytechnic Institute Announce Academic Collaboration 7
... Oct. 24 CME LLC (http://www.CMELLC.com ), ... programs,since 1978, today announced it has been granted ... as an approved sponsor of,continuing medical education for ... full approval as part of the APA,s,Continuing Education ...
... developed a new type of biodegradable nanoparticle. The ... makes it easier to target tumour tissue. These ... release of anticancer drugs. Rijcken recently gained her ... , Anticancer drugs sometimes have very harmful side ...
... used to be dogma that the brain was shut away ... outside forces of nature. But thats not how it is ... of Kevin Tracey, MD, it turns out that the brain ... the bodys inflammatory response to infection and autoimmune diseases. Understanding ...
... University of Liverpool have found that 73% of avian ... the initial infected farm, but larger outbreaks are more ... team from the Universitys Faculty of Veterinary Science and ... of Environment, Food and Rural Affairs (DEFRA) to produce ...
... Disease, ROCKVILLE, Md., Oct. 24 EntreMed, ... developing,therapeutics for the treatment of cancer and inflammatory ... Phase 2, open-label study for,Panzem(R) NCD (2ME2 or ... presented by Dr. Daniela Matei, principal investigator for,the ...
... Calif., Oct. 24 Anesiva,Inc. (Nasdaq: ANSV ) ... the markets close on Thursday, November 1, 2007 and ... day. Members of Anesiva,s,management team will discuss financial results ... overview of the company,s product pipeline, recent,events and milestones. ...
Cached Medicine News:Health News:CME LLC Granted Five-Year Full Approval by the American Psychological Association 2Health News:Nanoballs deliver drugs 2Health News:Scientists discover a direct route from the brain to the immune system 2Health News:Large avian flu outbreaks more likely to involve duck meat industry, experts find 2Health News:EntreMed Presents Results for Panzem(R) NCD Phase 2 Ovarian Cancer Study 2Health News:EntreMed Presents Results for Panzem(R) NCD Phase 2 Ovarian Cancer Study 3Health News:EntreMed Presents Results for Panzem(R) NCD Phase 2 Ovarian Cancer Study 4Health News:Anesiva to Announce Third Quarter 2007 Financial Results and Host Webcast Conference Call on November 1, 2007 2
(Date:5/22/2013)... TORONTO , May 22, 2013 /PRNewswire/ ... announced three presentations demonstrating the superiority of the AE37 ... Antigen Express, Inc. ( www.antigenexpress.com ). The presentations will ... Society of Clinical Oncology (ASCO) to be held in ... June 4, 2013. The presentation entitled " ...
(Date:5/22/2013)... -- Ranbaxy Laboratories Limited (hereafter, Ranbaxy), a subsidiary ... announced on May 22 the actions that Ranbaxy ... conduct under prior management ( ... to support Ranbaxy in its efforts to address ... led to the investigations by the U.S. Department ...
(Date:5/22/2013)... 22. Mai 2013  Grifols, ein globales ... Barcelona , Spanien, präsentierte die ... höhere Dosis von PROLASTIN©-C (Alpha1-Proteinasehemmer [human]) den ... (AAT) auf ein Niveau anhebt, das innerhalb ... liegt. ATT-Mangel ist eine lebensbedrohliche, genetische Erkrankung, ...
Breaking Medicine Technology:Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 2Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 3Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 4Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 2Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 3Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: