Navigation Links
Pancreatic cancer risk decreased by one anti-diabetic therapy, increased by others
Date:7/31/2009

Bethesda, MD (August 1, 2009) The antidiabetic medication metformin is associated with a reduced risk of pancreatic cancer in diabetics, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. However, other commonly used therapies, such as insulin or insulin secretagogues, may be associated with increased risk for the deadly disease.

"The current study demonstrated a robust protective effect of metformin against pancreatic cancer in diabetes. Our major observations were that diabetics who ever used metformin, especially those with greater than five years of use, had a reduced risk of pancreatic cancer compared to diabetics who had not taken these drugs," said Donghui Li, PhD, of The University of Texas M. D. Anderson Cancer Center and lead author of the study. "This adds evidence to previous study findings indicating that antidiabetic therapy can affect the development of cancer."

Study authors found that diabetics who took metformin had a 60 percent lower risk of pancreatic cancer, compared with those that had not taken metformin. This difference remained statistically significant when the analysis was restricted to patients with duration of diabetes greater than two years or those who never used insulin. Other diabetes-associated factors, including history of smoking, overweight or obesity, and glycemic control, did not have a significant effect on the relationship between metformin use and pancreatic cancer risk. In contrast, diabetics who had taken insulin or insulin secretagogues had 4.99- and 2.52-fold increased risks for pancreatic cancer, respectively, compared with never-users.

This hospital-based, case-control study, conducted at M. D. Anderson from 2004 through 2008, involved 973 patients with pancreatic adenocarcinoma (including 259 diabetics) and 863 controls (including 109 diabetics). Pancreatic cancer risk was estimated using unconditional logistic regression analysis.

"Further study is needed in other study populations to confirm or refute a possible role of antidiabetic therapy in pancreatic cancer. Since pancreatic cancer is a rapidly fatal, but a relatively uncommon cancer, epidemiological research on this disease is challenging," Dr. Li added. "If the finding that metformin is protective against pancreatic cancer is confirmed, metformin may offer a tool for the primary prevention of pancreatic cancer among people with type II diabetes."

Pancreatic cancer is the fourth leading cause of death from cancer for both men and women in the U.S. The association of type II diabetes mellitus and pancreatic cancer is complex. On one hand, type II diabetes can occur as a consequence of pancreatic cancer. On the other hand, there is accumulating evidence to strongly support a significant role of type II diabetes in pancreatic carcinogenesis.


'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Smoking increases potential for metastatic pancreatic cancer
2. New drug candidate prolongs the lives of pancreatic cancer patients
3. Dietary fat linked to pancreatic cancer
4. Eating Animal Fat May Lead to Pancreatic Cancer
5. Obesity While Young Boosts Pancreatic Cancer Risk
6. Being overweight, obese during early adulthood associated with greater risk of pancreatic cancer
7. Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
8. Epeius Biotechnologies Rexin-G Receives FDA Fast Track Designation for the Treatment of Pancreatic Cancer
9. Jefferson researchers identify critical marker of response to gemcitabine in pancreatic cancer
10. Mayo Clinic finds new pathology tests double sensitivity to detect bile duct and pancreatic cancers
11. $18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... David J. Dykeman , ... firm Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, 2016, at the ... series, and attorneys from the firm’s global Life Sciences & Medical Technology Group have ...
(Date:12/8/2016)... ... December 08, 2016 , ... STATEN ... been recognized for adherence to the highest standards of trauma, maternity, cancer and ... the center's president and CEO, Dr. Daniel Messina. , Among the recognitions, the ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the digital health platform ... by Canvas Ventures . Other investors include Nokia Growth Partners (NGP) and returning ... serve more consumers who are managing chronic conditions or simply want to ...
(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an ... families in and around the Cape Coral area, is embarking on a charity drive ... of Southwest Florida. , The Harry Chapin Food Bank of Southwest Florida works to ...
(Date:12/7/2016)... ... December 07, 2016 , ... Students ... have the unique opportunity to get hands-on experience in an emergency medical simulation, ... immersive experience to gain invaluable, real-life medical skills that are critical success in ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)...  A new study by a pair of Geisinger ... therapy to treat chronic pain is not only ineffective, ... consequences, including death. Palliative care physicians ... , M.D., authored the study which provides a review ... study was published in the December 2016 edition of ...
(Date:12/8/2016)... Dec. 8, 2016  EIP Pharma, LLC ( ... proof-of-mechanism for neflamapimod (previously code named VX-745), with ... clinical trials that demonstrated significant Alzheimer,s disease relevant ... treatment) and Study 303 (6-week treatment) are the ... Alzheimer,s Disease (CTAD) scientific conference in ...
(Date:12/8/2016)... 2016 Mederi Therapeutics Inc . hat die behördliche Zulassung ... für gastroösophageale Refluxerkrankung (GERD) – in China angekündigt. ... ... Live Stretta procedure performed and broadcast ... of Endoscopy at Wuhan Union Hospital ...
Breaking Medicine Technology: