Navigation Links
Pancreatic cancer risk decreased by one anti-diabetic therapy, increased by others
Date:7/31/2009

Bethesda, MD (August 1, 2009) The antidiabetic medication metformin is associated with a reduced risk of pancreatic cancer in diabetics, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. However, other commonly used therapies, such as insulin or insulin secretagogues, may be associated with increased risk for the deadly disease.

"The current study demonstrated a robust protective effect of metformin against pancreatic cancer in diabetes. Our major observations were that diabetics who ever used metformin, especially those with greater than five years of use, had a reduced risk of pancreatic cancer compared to diabetics who had not taken these drugs," said Donghui Li, PhD, of The University of Texas M. D. Anderson Cancer Center and lead author of the study. "This adds evidence to previous study findings indicating that antidiabetic therapy can affect the development of cancer."

Study authors found that diabetics who took metformin had a 60 percent lower risk of pancreatic cancer, compared with those that had not taken metformin. This difference remained statistically significant when the analysis was restricted to patients with duration of diabetes greater than two years or those who never used insulin. Other diabetes-associated factors, including history of smoking, overweight or obesity, and glycemic control, did not have a significant effect on the relationship between metformin use and pancreatic cancer risk. In contrast, diabetics who had taken insulin or insulin secretagogues had 4.99- and 2.52-fold increased risks for pancreatic cancer, respectively, compared with never-users.

This hospital-based, case-control study, conducted at M. D. Anderson from 2004 through 2008, involved 973 patients with pancreatic adenocarcinoma (including 259 diabetics) and 863 controls (including 109 diabetics). Pancreatic cancer risk was estimated using uncondit
'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Smoking increases potential for metastatic pancreatic cancer
2. New drug candidate prolongs the lives of pancreatic cancer patients
3. Dietary fat linked to pancreatic cancer
4. Eating Animal Fat May Lead to Pancreatic Cancer
5. Obesity While Young Boosts Pancreatic Cancer Risk
6. Being overweight, obese during early adulthood associated with greater risk of pancreatic cancer
7. Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
8. Epeius Biotechnologies Rexin-G Receives FDA Fast Track Designation for the Treatment of Pancreatic Cancer
9. Jefferson researchers identify critical marker of response to gemcitabine in pancreatic cancer
10. Mayo Clinic finds new pathology tests double sensitivity to detect bile duct and pancreatic cancers
11. $18 million awarded to TGen and University of Pennsylvania for pancreatic cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... York, NY (PRWEB) December 22, 2014 ... 2014 stronger than ever, having invested more than ... injured service members, veterans and their families. , ... for nearly a dozen nonprofits, helping with: veteran ... nursing scholarships; and life-coaches for severely injured veterans. ...
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount Labels ... a local organization that provides services to veterans and ... on a couple hundred acres in the hills of ... class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet shooting, ... ago to support U.S. Service men and women, police ...
(Date:12/22/2014)... TheHardwareCity.com now stocks MagnoGrip Pro Utility ... features. Customers of the large online tool shop enjoy ... delivered to their home or workplace with free shipping. ... incorporate heavy duty magnets, which make work easier. The ... store metal parts on the back of their hand, ...
(Date:12/22/2014)... 21, 2014 A substantial percentage ... computed tomography (CT) to evaluate abnormal findings on ... cancer, according to a new study published online ... the findings show that radiologist recommendations for additional ... to patient care. , RAIs, which have grown ...
(Date:12/21/2014)... December 22, 2014 Recently, BambooFlooringChina.com, a ... strand woven bamboo flooring collection , and launched a ... The promotion is valid until Jan. 30, 2015. , ... bamboo is the hardest bamboo flooring available today; it ... that of traditional teak hardwoods. Strand woven bamboo is ...
Breaking Medicine News(10 mins):Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2
... , MARYVILLE, Ill., June 11 Anderson Hospital ... Compirion Healthcare Solutions congratulate the ... upon its receipt of the coveted Pinnacle Award. The ED ... patient satisfaction, was chosen from a group of three finalists ...
... Children,s Research Hospital Announces New Leadership- , , ... the fundraising organization of St. Jude Children,s Research Hospital, ... Officer effective September 1, 2009. Shadyac has been ... years, most recently serving as chairman/president of the ALSAC ...
... BIRMINGHAM, Ala., June 11 HealthSouth Corporation (NYSE: HLS ... 9:30 a.m. ET on Wednesday, Aug. 5, 2009, to discuss its ... The conference call may be accessed by dialing (866) 406-5369 and ... and give the same pass code. Please call approximately 10 minutes ...
... have long-term impact , THURSDAY, June 11 (HealthDay ... and adopted daughters, research on mice has found. ... of the hormone prolactin in early pregnancy had substantial ... had delayed onset of puberty. , Prolactin, which is ...
... Legislation to let FDA regulate tobacco manufacturing and marketing ... -- The U.S. Senate,s historic vote late Thursday to ... tobacco products brought cheers from health organizations across the ... to Big Tobacco,s despicable marketing practices that are designed ...
... ... , ... (PRWEB) June 11, 2009 -- Stephen J. Cloobeck, Chairman and Chief Executive Officer of ... Nevada Cancer Institute (NVCI) effective July 1, 2009. Cloobeck succeeds founding Chairman of the ...
Cached Medicine News:Health News:Anderson ED Team Receives Pinnacle Award for Excellence in Customer Service 2Health News:Anderson ED Team Receives Pinnacle Award for Excellence in Customer Service 3Health News:ALSAC/St. Jude Names Richard C. Shadyac, Jr. as CEO 2Health News:ALSAC/St. Jude Names Richard C. Shadyac, Jr. as CEO 3Health News:HealthSouth Announces Date of 2009 Second Quarter Earnings Conference Call 2Health News:Postpartum Anxiety May Delay Puberty in Kids 2Health News:Health Organizations Cheer Senate Vote on Tobacco Control 2Health News:Health Organizations Cheer Senate Vote on Tobacco Control 3Health News:Nevada Cancer Institute Names Stephen J. Cloobeck Chairman of the Board 2Health News:Nevada Cancer Institute Names Stephen J. Cloobeck Chairman of the Board 3
(Date:12/19/2014)... DIEGO and CARDIFF-BY-THE-SEA, Calif. ... Inc. (NASDAQ: SRNE ;  Sorrento), an ... associated pain, and Conkwest, Inc., a privately-held immuno-oncology ... Natural Killer (NK) cell-line based therapy, announced today ... agreement to jointly develop next generation CAR-TNK™ (pronounced ...
(Date:12/19/2014)... Dec. 18, 2014 Somewhere between dropping five ... was forgotten. But Audicus , a next-generation hearing ... this new year. Hearing loss is the ... population, though it is often unaddressed. Forty-eight million Americans ... a hearing aid, mainly due to price. Hearing aids ...
(Date:12/19/2014)... , Dec. 18, 2014  Sage Analytics ( ... of equipment for the testing of marijuana potency ... the new Luminary™ Profiler, the industry,s first product ... in a cost-effective, portable unit. Designed ... needs of the cannabis industry, the Luminary™ Profiler ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5Audicus Will Help People Resolve to Hear Better in 2015 2Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2
... NEC Corporation (NEC) and privately held SomaLogic, Inc. announced ... aptamer (*1) related businesses in the life sciences and ... made an equity investment in SomaLogic in support of ... The agreement establishes a framework for the two ...
... Hologic, Inc. (Nasdaq: HOLX ) today announced ... present at the 2010 Morgan Stanley Global Healthcare Conference ... Interested parties are invited to listen to ... the investor section of the company,s website at ...
Cached Medicine Technology:NEC and SomaLogic Enter Agreement to Prepare for Delivery of Novel Forms of Health Information via Cloud Services 2NEC and SomaLogic Enter Agreement to Prepare for Delivery of Novel Forms of Health Information via Cloud Services 3
Blunt tipped forceps with tungsten carbide treated jaws for enhanced gripping and removal of large sized foreign bodies....
Blunt tipped forceps with a thin tip angled at approximately 135 and hollowed out "notch" on the interior of the distal end. Tip is shaped like a pic when in the closed position. For membrane peeling...
Blunt tlpped forceps wlth smooth jaws that have been diamond dusted for enhanced grasping. Excellent for grasping of immature membranes....
Microforceps : Asymmetrical Endgripping Forceps...
Medicine Products: