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Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases
Date:5/3/2010

at. Those with more fat had between a 30 percent and 400 percent increase in mortality.

Dr. Balentine will present these data on Wednesday, May 5 at 8 a.m. CT in Hall F, Ernest N. Morial Convention Center.

Image-Guided Stereotactic Radiosurgery for Locally Advanced Pancreatic Adenocarcinoma Results of First 85 Patients (Abstract #317)

New research from Sinai Hospital in Baltimore, MD, has found that locally advanced pancreatic cancer can be successfully controlled with stereotactic radiosurgery (SRS) which delivers beams of concentrated radiation to tumors with extreme accuracy and is administered non-invasively in outpatient settings.

Pancreatic cancer is extremely difficult to treat because it is not as sensitive to chemotherapy as other GI and body tumors. Surgery is available for about five to ten percent of diagnoses of locally advanced pancreatic cancer, but more often, radiation and chemotherapy are the two most common treatments.

Investigators, led by Mukund Didolkar, MD, director of surgical oncology, Sinai Hospital, and associate professor department of surgery, Johns Hopkins University School of Medicine, treated 85 patients with locally advanced and recurrent pancreatic adenocarcinoma with pancreatic SRS from February 2004 through August 2009. Patients were given SRS therapy with real time monitoring by CT scan over two to five days. The real-time monitoring allowed a more exact delivery of radiation adjusted for the motion of respiration. Following SRS treatment, patients received systemic chemotherapy to help control the spread of disease to other areas.

Patients experienced a local tumor control rate of 91.7 percent. Five patients experienced progression of the disease and three did not continue with follow-up. Survival time observed thus far is higher than with conventional radiation therapy. Most patients achieved mean survival over 11 months, compared with survival of five to eight months
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Contact: Amy Levey
alevey@gymr.com
202-745-5116
Digestive Disease Week
Source:Eurekalert

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