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Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases
Date:5/3/2010

ests a possible hereditary link between IBD and pancreatic neoplasia. They added that because few risk factors have been identified for the development of pancreatic malignancy making current screening attempts mostly ineffectual these results have potential implications for the early identification of patients with pancreatic cancer and may translate to improvements in survival similar to other forms of cancer where early screening has been employed successfully.

"Given a diagnosis of inflammatory bowel disease, specialized populations may benefit from efforts aimed at early detection where surgical intervention may offer a hope of long-term survival," said Jason Schwartz, MD, assistant professor of surgery, the University of Utah. "The survival rate for this cancer is currently very low, mostly because the tumor is discovered extremely late in its course."

Previous reports have examined the association between IBD and various other malignancies, but this study is the first to examine standardized incidence rates of IBD and pancreatic cancer, which is an estimate of the occurrence of cancer in a population relative to a larger comparison population designated as "normal" or "average."

Dr. Schwartz cautioned that people should not conclude that all patients with IBD will develop pancreatic cancer; more studies are needed to examine whether an increased risk of pancreatic cancer exists in extended family pedigrees of patients with IBD. If an increased predilection for pancreatic cancer exists in these family members, future studies will also focus on identification of the mode of inheritance as well as attempts to identify "susceptibility genes" that put patients at increased risk. He added that other studies may examine the utility of various screening modalities in susceptible populations.

Dr. Schwartz will present these data on Sunday, May 2 at 4:30 p.m. CT in 388-390, Ernest N. Morial Convention Center.

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Contact: Amy Levey
alevey@gymr.com
202-745-5116
Digestive Disease Week
Source:Eurekalert

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