Navigation Links
Pancreatic cancer: The smaller the tumor, the better your chances, study shows
Date:1/28/2008

The odds of surviving cancer of the pancreas increase dramatically for patients whose tumors are smallest, according to a new study by researchers at Saint Louis University and the M.D. Anderson Cancer Center in Houston the first study to specifically evaluate the link between tumor size and survival rates for one of the most common and deadly cancers.

The findings in the current edition of Pancreas (www.pancreasjournal.com) vividly underscore the importance of early diagnosis of pancreatic cancer, the researchers said.

Even though it seems intuitive and was supported by preliminary observations from earlier studies, for the first time we now have evidence that a progressive decrease in the size of a pancreatic tumor at the time of diagnosis improves patient outcomes rather dramatically, said Banke Agarwal, M.D., Associate Professor of gastroenterology at the Saint Louis University School of Medicine and lead author of the study.

These data emphasize the benefit and the need of finding and diagnosing tumors in the pancreas as early as possible, Agarwal added. In order to make progress against pancreatic cancer, we have to redouble our efforts to identify symptoms that are associated with the early stages of the disease.

Pancreatic cancer is the fourth most common cancer in the United States and one of the most deadly, responsible for more than 33,000 deaths a year, according to the National Institutes of Health.

Despite many advances in the fight against other cancers in recent years, the prognosis for patients diagnosed with the pancreatic cancer has remained extremely poor. Thats largely because the cancer is frequently not suspected and is difficult to diagnose in its early stages, when most people are asymptomatic or have non-specific symptoms that are easily ignored or attributed to other diseases.

The study looked at 65 patients who were diagnosed with pancreatic cancer at the M.D. Anderson Cancer in Houston between December 2000 and December 2001. Their average age was 67 years old; 38 were men.

Researchers found a striking correlation between a patients prognosis and the size of their tumor at the time of diagnosis.

Of the 12 patients whose tumors were 20 millimeters or smaller, their median survival after diagnosis was 17.2 months. For those with tumors 21-25 mm, median survival was 12.3 months. For those with tumors 26-30 mm, median survival was 8.5 months. And for those with tumors larger than 30 mm, median survival was 7.6 months. Of those patients whose tumors were 20 mm or smaller, two were still alive after 48 months; none of the patients with tumors larger than 30 mm were alive after 36 months.

Unfortunately, while the patients with the smallest tumors had the highest rates of survival, they were relatively small in number. Only 12 patients or 18 percent had tumors 20 mm or smaller. By contrast, the largest group of patients 27, or 42 percent had tumors larger than 30 mm.

In addition, the average tumor size of patients in the study was 32.9 mm well above the threshold at which survival rates are lowest. That figure is roughly comparable to an average tumor size of about 30 mm among pancreatic cancer patients in general, according to the study.

These numbers illustrate why weve made so little progress in improving outcomes for people who are diagnosed with pancreatic cancer were not finding their tumors until theyre too big and its too late, Agarwal said. We know we have a much better chance of helping someone survive pancreatic cancer if its caught early and their tumor is small.

Major advances in imaging technology in recent years have greatly improved physicians ability to diagnose progressively smaller pancreatic tumors. This hasnt led to earlier diagnosis, however, because patients generally dont get to the doctor until symptoms appear and by then its too late.

Agarwal said researchers will need to focus on finding ways to identify people who should be screened early for pancreatic cancer. Screening of the general population for the disease hasnt proven effective but screening of people with a family history of pancreatic cancer is under active investigation, he said.

In addition, preliminary data from other studies have shown that elderly people whove been recently diagnosed with diabetes or depression have a higher likelihood of pancreatic cancer providing another avenue for researchers to explore, Agarwal said.


'/>"/>

Contact: Donn Walker
dwalke18@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert

Related medicine news :

1. Elusive pancreatic progenitor cells found in mice
2. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
3. The most important candidate genes for pancreatic stone formation
4. Protein Gives Clues to Pancreatic Cancer
5. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
6. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
7. Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
8. Mislabeled Supplement Spurred Prostate Cancer: Report
9. Mislabled Supplement Spurred Prostate Cancer: Report
10. NCBA Statement on 2007 WCRF/AICR Second Expert Report on Food, Nutrition and Physical Activity and the Prevention of Cancer:
11. From Hot Flashes to Breast Cancer: ZRT Labs Hormone Testing Catches On As Women Consider Safer, More Natural Options.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... Advanced Spine ... fluid/“stem cells” and Platelet Rich Plasma (PRP) injections. “These are becoming the ‘go-to’ ... Baranski, D.C., of Advanced Spine & Sport Medical. “We are very excited to ...
(Date:5/1/2016)... ... May 01, 2016 , ... Women's Excellence in Wellness, powered ... taught by Patti Dolan, a Young Living Gold Member. , The class will be ... followed by a small intro to the Oils that can benefit participant's yoga practice, ...
(Date:5/1/2016)... ... 2016 , ... ProBrand Reveal Volume 2 is a set of versatile and smooth logo reveals ... animations, users can easily create a unique logo reveal in just a matter of minutes. ... Use these title presets to add a uniquely animated logo to any photos or videos. ...
(Date:5/1/2016)... ... May 01, 2016 , ... Good Circle Insurance Agency ... of chiropractic help. The agency offers a verity of health, life and injury policies ... to Chris Nelson at the firm, “Many insurance plans don’t cover chiropractic care, so ...
(Date:4/30/2016)... ... April 30, 2016 , ... Create an abstract shape animation ... and manipulate three-dimensional shapes with ease all within Apple Motion . Users ... polygon texture animation, opacity texture animation, overall shape texture displacement, twist, camera controls, ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 28, 2016   Acsis , a leading provider ... IT market research and advisory firm IDC has named ... MarketScape: Worldwide Pharmaceutical Track and Trace Software 2016 Vendor ... an assessment of the capabilities and business strategies of ... market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/27/2016)... Inc. (Nasdaq: HOLX ) announced today ... quarter ended March 26, 2016.  GAAP diluted earnings ... non-GAAP diluted EPS of $0.47 increased 14.6%.  Revenue ... basis, and 6.3% on a constant currency basis.  ... highlighted by 14.6% growth in non-GAAP EPS," said ...
(Date:4/27/2016)... , April 27, 2016 ... accelerator (MR-linac) platform will be the focal point of ... of the European Society for Radiotherapy & Oncology, taking ... MR-linac integrates a state-of-the-art radiotherapy system and a high-field ... to clearly see the patient,s anatomy in real time. ...
Breaking Medicine Technology: