Navigation Links
Pancreatic Cancer May Have a New Foe
Date:12/15/2008

Blocking a particular gene could put brakes on killer disease, scientists say

MONDAY, Dec. 15 (HealthDay News) -- Proteins produced by a particular gene may provide a new target for treating deadly pancreatic cancer, researchers say.

Experiments at the Mayo Clinic College of Medicine in Minnesota show the "Seven-In-Absentia-Homolog" (SIAH) protein can shut down a key pathway in another gene that, in a mutated form, has been previously linked to excessive growth of pancreatic cancer.

Pancreatic cancer is expected to be diagnosed in nearly 38,000 people in the United States this year, according to the American Cancer Society, and about 34,000 will die of the disease. Even when detected early, the 5-year survival from pancreatic malignancy is about 33 percent.

The findings are scheduled to be presented Sunday at the American Society for Cell Biology annual meeting, in San Francisco.

"By attacking the SIAH-based protein-degrading machinery, we block tumor formation in one of the most aggressive human cancers cells known," Mayo researcher Amy Tang said in a news release issued by the conference organizers.

The mutated gene, K-RAS, normally promotes growth but in its abnormal form is kicks into overdrive opening a major signaling pathway that help increase cell growth people with pancreatic cancer.

In experiments with fruit flies, increased SIAH expression was associated with increased grades and aggressiveness of pancreatic cancer.

Tang said study should follow into whether SIAH inhibition can treat pancreatic cancer in humans.

More information

The American Cancer Society has more about pancreatic cancer .



-- Kevin McKeever



SOURCE: American Society for Cell Biology, news release, Dec. 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer
2. IDO2 an active enzyme to target in pancreatic cancer
3. Radiation before surgery improves pancreatic cancer outcomes
4. Join the Pancreatic Cancer Action Network and Raise Your Voice in November for Pancreatic Cancer Awareness Month
5. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
6. Radiosurgery Proves Viable for Some Pancreatic Cancers
7. Pancreatic Cells Turned Into Insulin-Producing Beta Cells
8. The Pancreatic Cancer Action Network is Saddened by the Death of NFL Hall of Fame Member Gene Upshaw
9. Pancreatic Cancer Biomarkers Found
10. New treatment combination safe for pancreatic cancer patients
11. 3-Drug Combo Improves Advanced Pancreatic Cancer Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pancreatic Cancer May Have a New Foe
(Date:5/27/2016)... ... 27, 2016 , ... W.S. Badger Co. Inc ., the maker of ... recognized as one of the best small businesses for new dads by Fatherly, the ... small businesses providing progressive benefits to new parents on the organization’s 2016 Best ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response ... many who are unaware of the plight of aphasia. In collaboration with the ... “Stroke Awareness” campaign. , The link between stroke and aphasia is relatively unknown, ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a ... medical and food industries. Aside from its GMP accreditation, Validation Center is also ... successfully certified products, services and staff. , Validation Center is ISO17025 accredited and ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... outcomes, hosted members and suppliers for its inaugural Member Conference at the Paris ... mission of elevating the operational health of America’s healthcare providers. , The conference ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia is ... impact on long-term patient survival, reports a team of UPMC researchers in the ... in the Journal of Thoracic and Cardiovascular Surgery, provide critical information that will ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior ... executive officer, today. In his new role, Marziani will lead the company,s business development ... professionals to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... 24, 2016 ... , la première endoprothèse à double thérapie ... l,intervention portant sur les membres inférieurs et ... OrbusNeich, entreprise mondiale spécialisée dans la fourniture ... vie, a élargi son portefeuille pour inclure ...
Breaking Medicine Technology: