Navigation Links
Pancreatic Cancer May Have a New Foe
Date:12/15/2008

Blocking a particular gene could put brakes on killer disease, scientists say

MONDAY, Dec. 15 (HealthDay News) -- Proteins produced by a particular gene may provide a new target for treating deadly pancreatic cancer, researchers say.

Experiments at the Mayo Clinic College of Medicine in Minnesota show the "Seven-In-Absentia-Homolog" (SIAH) protein can shut down a key pathway in another gene that, in a mutated form, has been previously linked to excessive growth of pancreatic cancer.

Pancreatic cancer is expected to be diagnosed in nearly 38,000 people in the United States this year, according to the American Cancer Society, and about 34,000 will die of the disease. Even when detected early, the 5-year survival from pancreatic malignancy is about 33 percent.

The findings are scheduled to be presented Sunday at the American Society for Cell Biology annual meeting, in San Francisco.

"By attacking the SIAH-based protein-degrading machinery, we block tumor formation in one of the most aggressive human cancers cells known," Mayo researcher Amy Tang said in a news release issued by the conference organizers.

The mutated gene, K-RAS, normally promotes growth but in its abnormal form is kicks into overdrive opening a major signaling pathway that help increase cell growth people with pancreatic cancer.

In experiments with fruit flies, increased SIAH expression was associated with increased grades and aggressiveness of pancreatic cancer.

Tang said study should follow into whether SIAH inhibition can treat pancreatic cancer in humans.

More information

The American Cancer Society has more about pancreatic cancer .



-- Kevin McKeever



SOURCE: American Society for Cell Biology, news release, Dec. 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer
2. IDO2 an active enzyme to target in pancreatic cancer
3. Radiation before surgery improves pancreatic cancer outcomes
4. Join the Pancreatic Cancer Action Network and Raise Your Voice in November for Pancreatic Cancer Awareness Month
5. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
6. Radiosurgery Proves Viable for Some Pancreatic Cancers
7. Pancreatic Cells Turned Into Insulin-Producing Beta Cells
8. The Pancreatic Cancer Action Network is Saddened by the Death of NFL Hall of Fame Member Gene Upshaw
9. Pancreatic Cancer Biomarkers Found
10. New treatment combination safe for pancreatic cancer patients
11. 3-Drug Combo Improves Advanced Pancreatic Cancer Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pancreatic Cancer May Have a New Foe
(Date:8/22/2017)... , ... August 22, 2017 , ... “Wilderness Voices”: a ... world travel. “Wilderness Voices” is the creation of published author, Martha McKown, an ... McKown was inspired as a very young child when her older sisters studied High ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: is a unique ... Of Light” is the creation of published author, J.M. Shepherd, a writer, teacher, traveler, ... to life’s perplexing mysteries. , Shepherd shares, “Love is one of the least understood ...
(Date:8/22/2017)... ... 22, 2017 , ... “Call Of Spiritual Duty”: a revelation in an era ... C.S. Lizarde. Growing up on the streets of North Visalia, California, Carlos Lizarde ... apply the Biblical keys to his life, he noticed immediately that opportunities and blessings ...
(Date:8/21/2017)... Ca (PRWEB) , ... August 22, 2017 , ... ... industries, but not without risk to health and safety. By learning and implementing ... be eliminated. , In this webinar, attendees will gain a better understanding ...
(Date:8/21/2017)... Aliso Viejo, CA (PRWEB) , ... August 21, 2017 , ... ... Pixel Film Studios. Editors can quickly and easily add washed color grades to ... an image. The LUT changes every pixel’s color to the corresponding color indicated by ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... Md. , Aug. 4, 2017 The ... or shortly after a physician/patient consult has long been ... and was a notable focus of the largest meeting ... is according to healthcare market research firm Kalorama Information. ... care testing (POCT) offerings or related supplies and software ...
(Date:8/2/2017)... -- Life Flight Network and PeaceHealth Oregon Network announced they renewed ... operational efficiency for patients at hospitals in Eugene ... Grove , and Florence, Oregon , ... Network work collaboratively to move patients who require the highest ... sensitive emergency exists. ...
(Date:7/31/2017)... 7D Surgical, developer of ground breaking surgical navigation ... Surgical System to support its strategic sales plan in ... and Virginia.  7D Surgical has entered into an exclusive sales ... medical facilities within those markets. ... Spartan Medical Purchases ...
Breaking Medicine Technology: