Navigation Links
Pancreatic Cancer May Have a New Foe
Date:12/15/2008

Blocking a particular gene could put brakes on killer disease, scientists say

MONDAY, Dec. 15 (HealthDay News) -- Proteins produced by a particular gene may provide a new target for treating deadly pancreatic cancer, researchers say.

Experiments at the Mayo Clinic College of Medicine in Minnesota show the "Seven-In-Absentia-Homolog" (SIAH) protein can shut down a key pathway in another gene that, in a mutated form, has been previously linked to excessive growth of pancreatic cancer.

Pancreatic cancer is expected to be diagnosed in nearly 38,000 people in the United States this year, according to the American Cancer Society, and about 34,000 will die of the disease. Even when detected early, the 5-year survival from pancreatic malignancy is about 33 percent.

The findings are scheduled to be presented Sunday at the American Society for Cell Biology annual meeting, in San Francisco.

"By attacking the SIAH-based protein-degrading machinery, we block tumor formation in one of the most aggressive human cancers cells known," Mayo researcher Amy Tang said in a news release issued by the conference organizers.

The mutated gene, K-RAS, normally promotes growth but in its abnormal form is kicks into overdrive opening a major signaling pathway that help increase cell growth people with pancreatic cancer.

In experiments with fruit flies, increased SIAH expression was associated with increased grades and aggressiveness of pancreatic cancer.

Tang said study should follow into whether SIAH inhibition can treat pancreatic cancer in humans.

More information

The American Cancer Society has more about pancreatic cancer .



-- Kevin McKeever



SOURCE: American Society for Cell Biology, news release, Dec. 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer
2. IDO2 an active enzyme to target in pancreatic cancer
3. Radiation before surgery improves pancreatic cancer outcomes
4. Join the Pancreatic Cancer Action Network and Raise Your Voice in November for Pancreatic Cancer Awareness Month
5. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
6. Radiosurgery Proves Viable for Some Pancreatic Cancers
7. Pancreatic Cells Turned Into Insulin-Producing Beta Cells
8. The Pancreatic Cancer Action Network is Saddened by the Death of NFL Hall of Fame Member Gene Upshaw
9. Pancreatic Cancer Biomarkers Found
10. New treatment combination safe for pancreatic cancer patients
11. 3-Drug Combo Improves Advanced Pancreatic Cancer Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pancreatic Cancer May Have a New Foe
(Date:6/24/2017)... ... June 24, 2017 , ... Doorknobs are for convenience, deadbolts are ... getting a guard dog or having an alarm system installed. But unless there is ... entry. Yair Frenkel, owner of TX Premier Locksmith in Killeen, TX says: “In the ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... By scoring ... its ninth consecutive four-star rating from premier online charity evaluator, Charity Navigator, validating ANRF's ... top 1% of all charities reviewed by Charity Navigator and earns ANRF a spot ...
(Date:6/23/2017)... Va. (PRWEB) , ... June 23, 2017 , ... The ... the president's nominee for deputy secretary of Veterans Affairs, retired Marine Col. Thomas G. ... Veterans Affairs. , Bowman brings an intimacy with the issues and challenges ...
(Date:6/23/2017)... New York, NY (PRWEB) , ... June 23, 2017 , ... ... prefer to watch it while others prefer to read it, and some people don't ... printed versus visual pornography. Here's what they found: , Erotic literature can give readers ...
(Date:6/23/2017)... D.C. (PRWEB) , ... June 23, 2017 , ... ... during cooking is essential, and two new videos highlight the importance of correctly ... Specialist Christine Bruhn, Ph.D., who has done extensive research on consumer food safety ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... 2017 The Bio Supply Management Alliance (BSMA) ... Fremont and the Biomedical Manufacturing Network to ... California by providing a platform ... fostering workforce development. The primary focus of this alliance ... as well as small and mid-sized biomedical companies. ...
(Date:6/13/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... U.S. Food and Drug Administration (FDA) has notified the Company ... its Zhejiang, China manufacturing facility has ... successful clearance of the Warning Letter related to our ... measure of the progress we have made in our ongoing ...
(Date:6/11/2017)... INDIANAPOLIS , June 10, 2017  Eli Lilly and ... results from three Phase 3 studies of galcanezumab, an ... migraine, including late-breaking data on several key secondary endpoints ... Detailed results from these studies (EVOLVE-1, EVOLVE-2 and REGAIN) ... (AHS) annual scientific meeting in Boston ...
Breaking Medicine Technology: