Navigation Links
Pancreatic Cancer May Have a New Foe
Date:12/15/2008

Blocking a particular gene could put brakes on killer disease, scientists say

MONDAY, Dec. 15 (HealthDay News) -- Proteins produced by a particular gene may provide a new target for treating deadly pancreatic cancer, researchers say.

Experiments at the Mayo Clinic College of Medicine in Minnesota show the "Seven-In-Absentia-Homolog" (SIAH) protein can shut down a key pathway in another gene that, in a mutated form, has been previously linked to excessive growth of pancreatic cancer.

Pancreatic cancer is expected to be diagnosed in nearly 38,000 people in the United States this year, according to the American Cancer Society, and about 34,000 will die of the disease. Even when detected early, the 5-year survival from pancreatic malignancy is about 33 percent.

The findings are scheduled to be presented Sunday at the American Society for Cell Biology annual meeting, in San Francisco.

"By attacking the SIAH-based protein-degrading machinery, we block tumor formation in one of the most aggressive human cancers cells known," Mayo researcher Amy Tang said in a news release issued by the conference organizers.

The mutated gene, K-RAS, normally promotes growth but in its abnormal form is kicks into overdrive opening a major signaling pathway that help increase cell growth people with pancreatic cancer.

In experiments with fruit flies, increased SIAH expression was associated with increased grades and aggressiveness of pancreatic cancer.

Tang said study should follow into whether SIAH inhibition can treat pancreatic cancer in humans.

More information

The American Cancer Society has more about pancreatic cancer .



-- Kevin McKeever



SOURCE: American Society for Cell Biology, news release, Dec. 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer
2. IDO2 an active enzyme to target in pancreatic cancer
3. Radiation before surgery improves pancreatic cancer outcomes
4. Join the Pancreatic Cancer Action Network and Raise Your Voice in November for Pancreatic Cancer Awareness Month
5. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
6. Radiosurgery Proves Viable for Some Pancreatic Cancers
7. Pancreatic Cells Turned Into Insulin-Producing Beta Cells
8. The Pancreatic Cancer Action Network is Saddened by the Death of NFL Hall of Fame Member Gene Upshaw
9. Pancreatic Cancer Biomarkers Found
10. New treatment combination safe for pancreatic cancer patients
11. 3-Drug Combo Improves Advanced Pancreatic Cancer Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pancreatic Cancer May Have a New Foe
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- One of Australia,s successful biotechnology scientists, ... new biotechnology company, Noxopharm Limited [ABN 50 608 966 123] ("Noxopharm"). ... list on the ASX. Noxopharm is a clinic-ready company ... Phase 1 clinical study later this year. ... biggest problems facing cancer patients - the ability of cancers to ...
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
Breaking Medicine Technology: