Navigation Links
Pancreatic Cancer Biomarkers Found
Date:6/13/2008

Blood test for 5 proteins could detect disease sooner, when it's more treatable

FRIDAY, June 13 (HealthDay News) -- Five proteins linked to early development of pancreatic cancer have been identified by U.S. researchers, who said the finding is a step forward in efforts to develop a blood test to detect this type of cancer in the early stages, when cure rates are highest.

"Our team identified, for the first time, protein changes associated with early-stage pancreatic tumor development in genetically engineered mice that were also found to be associated with the presence of disease in humans at an early, pre-symptomatic stage," senior author Dr. Samir Hanash, of the Fred Hutchinson Cancer Research Center in Seattle, said in a prepared statement.

They first identified the five proteins in mice with a precancerous condition called pancreatic intraepithelial neoplasma. The condition, if left untreated, eventually progresses to full-blown pancreatic cancer. The researchers then looked for the same proteins in blood samples from 13 people with asymptomatic, early-stage pancreatic cancer.

The study was published in this week's issue of the online journal PLoS Medicine.

If this five-biomarker panel can be developed into a commercial screening test, it may prove particularly useful when combined with a currently available test that measures levels of a pancreatic cancer biomarker called CA19.9. Eighty percent of newly diagnosed pancreatic cancer patients have elevated levels of CA19.9, which is not linked to early-stage disease with symptoms.

The researchers suggested that combined use of the five-biomarker panel and the CA19.9 test may greatly improve detection of early-stage pancreatic cancer before the onset of symptoms and may also help distinguish between cancer and pancreatitis, a noncancerous, inflammatory condition.

Pancreatic cancer is the fourth leading cause of cancer death in the United States. It has a five-year survival rate of only 3 percent. Because there are no symptoms in the early stages, most patients aren't diagnosed until the cancer has spread beyond the pancreas. This is a major reason for the poor long-term survival rates.

More information

The American Cancer Society has more about pancreatic cancer.



-- Robert Preidt



SOURCE: Fred Hutchinson Cancer Research Center, news release, June 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New treatment combination safe for pancreatic cancer patients
2. 3-Drug Combo Improves Advanced Pancreatic Cancer Outcomes
3. Beer Drinking May Speed Pancreatic Cancer Onset
4. Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
5. The Pancreatic Cancer Action Network Announces Its 2008 Research Grant Awards Totaling Over $1 Million in New Research Funding
6. Calorie restricted diet prevents pancreatic inflammation and cancer
7. Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find
8. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
9. Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
10. Patrick Swayzes Diagnosis With Pancreatic Cancer: a Statement From the Pancreatic Cancer Action Network
11. Treatment Combo for Pancreatic Cancer Has Limited Benefit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... ... “The Inn at the Mill”: a story of love and redemption, hope and uncertainty ... and content. , “The Inn at the Mill” is the creation of published author, ... and is now living in Berks County on Crow Hill. The inn, the ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... programs and resources at seafoodnutrition.org/programs and seafoodnutrition.org/resources to assist in teaching communities ... These resources have been developed for use by nutrition educators and influencers ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Some Infallible Characteristics of Christ”: a ... Characteristics of Christ” is the creation of published author, Rev. Dr. Robert W. Thomas, ... thirteen years, a preacher for over nineteen, a pastor for over fifteen years. He ...
(Date:1/22/2017)... ... January 22, 2017 , ... Phytocéane invites clients to take an ... of the world with ZANZIBAR MILKY CREAM. Inspired by the beauty of Zanzibar, a ... Coconut Oil and moisturizing vegetal coral to create this gentle, velvety body cream to ...
(Date:1/22/2017)... ... 22, 2017 , ... "Photo Cloud allows FCPX users to add favorited photos ... complete ease," said Christina Austin - CEO of Pixel Film Studios. , To ... timeline. Presets include scenes with one, three, four or five focus points. There ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... 2017 Stock-Callers.com today evaluates the following ... ), Novo Nordisk A/S (NYSE: NVO ), Sucampo ... Holdings Inc. (NASDAQ: PTX ). These stocks belong ... th , 2017, finishing near its session lows. As per ... 0.7%, while shares of health care companies in the S&P ...
(Date:1/20/2017)... January 20, 2017 Avillion LLP, a co-developer ... Mark Weinberg , MD MBA as Chief Medical Officer. Dr ... USA . ... Dr Weinberg has spent more than 17 years as a ... companies to micro-cap biotech. Over the course of his career, he ...
(Date:1/19/2017)... Jan. 19, 2017 The U.S. Food and Drug ... Idiopathic Constipation (CIC) in adult patients. "No ... disorders," said Julie Beitz , M.D., director of the ... Drug Evaluation and Research. "With the availability of new therapies, ... for their condition." ...
Breaking Medicine Technology: