Navigation Links
Pancreatic Cancer Biomarkers Found

Blood test for 5 proteins could detect disease sooner, when it's more treatable

FRIDAY, June 13 (HealthDay News) -- Five proteins linked to early development of pancreatic cancer have been identified by U.S. researchers, who said the finding is a step forward in efforts to develop a blood test to detect this type of cancer in the early stages, when cure rates are highest.

"Our team identified, for the first time, protein changes associated with early-stage pancreatic tumor development in genetically engineered mice that were also found to be associated with the presence of disease in humans at an early, pre-symptomatic stage," senior author Dr. Samir Hanash, of the Fred Hutchinson Cancer Research Center in Seattle, said in a prepared statement.

They first identified the five proteins in mice with a precancerous condition called pancreatic intraepithelial neoplasma. The condition, if left untreated, eventually progresses to full-blown pancreatic cancer. The researchers then looked for the same proteins in blood samples from 13 people with asymptomatic, early-stage pancreatic cancer.

The study was published in this week's issue of the online journal PLoS Medicine.

If this five-biomarker panel can be developed into a commercial screening test, it may prove particularly useful when combined with a currently available test that measures levels of a pancreatic cancer biomarker called CA19.9. Eighty percent of newly diagnosed pancreatic cancer patients have elevated levels of CA19.9, which is not linked to early-stage disease with symptoms.

The researchers suggested that combined use of the five-biomarker panel and the CA19.9 test may greatly improve detection of early-stage pancreatic cancer before the onset of symptoms and may also help distinguish between cancer and pancreatitis, a noncancerous, inflammatory condition.

Pancreatic cancer is the fourth leading cause of cancer death in the United States. It has a five-year survival rate of only 3 percent. Because there are no symptoms in the early stages, most patients aren't diagnosed until the cancer has spread beyond the pancreas. This is a major reason for the poor long-term survival rates.

More information

The American Cancer Society has more about pancreatic cancer.

-- Robert Preidt

SOURCE: Fred Hutchinson Cancer Research Center, news release, June 9, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New treatment combination safe for pancreatic cancer patients
2. 3-Drug Combo Improves Advanced Pancreatic Cancer Outcomes
3. Beer Drinking May Speed Pancreatic Cancer Onset
4. Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
5. The Pancreatic Cancer Action Network Announces Its 2008 Research Grant Awards Totaling Over $1 Million in New Research Funding
6. Calorie restricted diet prevents pancreatic inflammation and cancer
7. Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find
8. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
9. Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
10. Patrick Swayzes Diagnosis With Pancreatic Cancer: a Statement From the Pancreatic Cancer Action Network
11. Treatment Combo for Pancreatic Cancer Has Limited Benefit
Post Your Comments:
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group ... Tournament held on June 20th at the Woodmont Country Club at 1201 Rockville ... an organization dedicated to helping service members that have been wounded in battle and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
(Date:6/23/2016)... , June 23, 2016 ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, ... Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast to ... The global pharmaceutical excipients market ... at a CAGR of 6.1% in the forecast period ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology: