Navigation Links
Panacea Pharmaceuticals Announces Selection of PAN-622 - A Fully Human Sequence Monoclonal Antibody Against HAAH - As Its Lead Cancer Therapeutic Product
Date:12/5/2007

6% to 0.1%. Similarly, in a xenograft model of human liver cancer, anti-HAAH antibodies inhibited tumor growth in all animals, with 40% showing no visible tumor. In an animal model of metastatic human colon cancer, treatment with anti-HAAH antibodies inhibits metastasis. To date, PAN-622 has demonstrated the best performance in xenograft models of human liver cancer as measured by inhibition of tumor growth, and thus has been selected as Panacea's lead anti-cancer drug candidate. In recent experiments, nude mice were injected subcutaneously with a human liver cancer cell line and tumors were allowed to grow for 3 days prior to the initiation of treatment. Animals were treated three times per week with PAN-622 or a non-relevant human IgG for four weeks. Mice were observed for a three weeks after the cessation of treatment. PAN-622 inhibited tumor growth in all animals by about 90%, with 40% showing no visible tumor. Tumors did not re-grow in these animals in the period after treatment cessation.

"PAN-622 has demonstrated excellent inhibition of tumor growth in animal models of cancer, and as a cancer-specific therapeutic, should have a low toxicity and adverse effect profile," commented Hossein Ghanbari, Ph.D, Founder, Chairman, CEO and CSO at Panacea Pharmaceuticals. "We are confident that the performance of PAN-622 in animals will be replicated in humans, and quite excited about the potential for this product to effectively treat a broad range of cancers."

HAAH was discovered by researchers at Brown University and the Rhode Island Hospital. Panacea holds worldwide exclusive rights to develop and commercialize therapeutic and diagnostic products based on HAAH, and as such owns the rights to PAN-622. PAN-622 is manufactured in high yield under cGMP guidelines, and should enter Phase 1 clinical trials in early 2009 with an initial indication for the treatment of hepatocellular carcinoma.

About Panacea's Oncology Platform

In addition to the
'/>"/>

SOURCE Panacea Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Panacea Pharmaceuticals Announces the Availability of CC Detect(SM), a Serum-Based Diagnostic Test for Colon Cancer
2. Arena Pharmaceuticals to Present at the NewsMakers in the Biotech Industry Conference
3. Schering-Plough/Merck Pharmaceuticals Announce FDA Filing Acceptance of New Drug Application for Loratadine/Montelukast Tablet
4. Transcept Pharmaceuticals, Inc. to Present at 2007 BIO Investor Forum
5. Provectus Pharmaceuticals, Inc. Begins Phase 2 Clinical Trial for Metastatic Melanoma
6. Idenix Pharmaceuticals to Present at Two Upcoming Investor Conferences
7. Vista Partners Updates Coverage on Tapestry Pharmaceuticals
8. Transcept Pharmaceuticals, Inc. to Present at UBS 2007 Global Life Sciences Conference
9. Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Tapestry Pharmaceuticals, Inc.
10. Amylin Pharmaceuticals to Webcast Corporate Overview During 43rd Annual Meeting of the European Association for the Study of Diabetes
11. Major Pharma Clinical Case Studies From Amgen, AstraZeneca, GSK, Intermune, Cephalon Inc, Sunesis Pharmaceuticals and Dartmouth Medical School During Fall Clinical Focused Programs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Eye doctors have long known that staring at ... tear film in the eyes to lose water and become ... staring at a computer screen can also alter the tear ... computers, the tear film and dry eye for years and ... Sarah, “Staring at Screen is Altering Your Tears, Study Finds,” ...
(Date:9/18/2014)... CA (PRWEB) September 18, 2014 Sutter ... Ray Dolby, founder of Dolby Laboratories, by naming the ... The family of Ray Dolby provided a founding gift ... Health Center, which provides services to patients and families ... than 2,000 people have been treated at the center ...
(Date:9/18/2014)... Choosing the insulation for the most out-of-the-way corner ... to most homeowners, but Clean Crawls’ recently released article ... opinion, they explain why spray foam insulation is the best ... crawl space. , They highlight not only its incredibly ... air tight seal and moisture protective abilities. For an area ...
(Date:9/18/2014)... A recent press release announced that that new ... States Food and Drug Administration for fat cell destruction. While ... dermatology center Maryland Laser Skin and Vein is one of ... use this advanced technique. , “We are very excited to ... patients the new UltraShape system. UltraShape is a welcome addition ...
(Date:9/18/2014)... On August 23, the HearStrong ... the Distinguished Service Award for his contributions to the ... National Basketball Retired Players Association (NBRPA) Legends World Sports ... Chicago Bulls in 1977, Glenn would go on to ... the Atlanta Hawks, and the Milwaukee Bucks throughout his ...
Breaking Medicine News(10 mins):Health News:New Study Confirms that Staring at a Computer Screen Alters Tear Film Content and Causes Dry Eye 2Health News:New Study Confirms that Staring at a Computer Screen Alters Tear Film Content and Causes Dry Eye 3Health News:Sutter Health’s CPMC announces Ray Dolby Brain Health Center 2Health News:Sutter Health’s CPMC announces Ray Dolby Brain Health Center 3Health News:Why Spray Foam Insulation is the Best Choice for Crawl Spaces Explained in Recent Article by Clean Crawls 2Health News:New FDA-Approved UltraShape Body Contouring Procedure Comes to Maryland Laser Skin and Vein 2Health News:The HearStrong Foundation Recognizes Mike “Stinger” Glenn with the Distinguished Service Award at the 2014 Legends World Sports Conference 2Health News:The HearStrong Foundation Recognizes Mike “Stinger” Glenn with the Distinguished Service Award at the 2014 Legends World Sports Conference 3
... Neurologists at the University at Buffalo are beginning a ... the cause of multiple sclerosis (MS). The researchers will ... from narrowing of the primary veins outside the skull, ... CCSVI is a complex vascular condition discovered ...
... Study shows ways to optimize hand movements , FRIDAY, Oct. ... make it easier for people with multiple sclerosis to pick ... with MS use excessive force when lifting objects, which can ... from the University of Illinois at Chicago explained in a ...
... 29th October is "What can I do?". As the World ... symptoms and take action, learn to recognise the risk factors ... the European Society of Cardiology (ESC) emphasises that most of ... coronary heart disease - and thus the object of the ...
... to behavior dictated by society in which they live, researchers ... wide varieties of culture that differ from nation to nation, ... a new study suggests that chimpanzees have their own form ... found that chimpanzee populations that live next to each other ...
... relieves pain as well as seven-day regimen, researchers find , ... antibiotics may be as effective as a seven-day course in ... study has found. , The study appears in the October ... Neck Surgery . , Pain after a tonsillectomy can make ...
... and a possible death,toll into the millions, UC Davis ... diseases that move between,wildlife and people. The global ... of up to $75 million over five years and ... for International Development,(USAID) known in combination as the Emerging ...
Cached Medicine News:Health News:Buffalo neurologists investigate possible new underlying cause of MS 2Health News:Buffalo neurologists investigate possible new underlying cause of MS 3Health News:Buffalo neurologists investigate possible new underlying cause of MS 4Health News:Light Touch Helps Grip of MS Patients 2Health News:Learning the risks for stroke -- and taking action 2Health News:Learning the risks for stroke -- and taking action 3Health News:Chimps Show Signs of Culture 2Health News:After Tonsillectomy, Short-Term Antibiotics Effective: Study 2Health News:UC Davis leads attack on deadly new diseases 2Health News:UC Davis leads attack on deadly new diseases 3
(Date:9/17/2014)... 17, 2014  The law firm McElroy, Deutsch, ... it will serve as host for "Show Me ... Risks of Healthcare Reform," a one-day conference scheduled ... systems, reimbursement, compliance and enforcement in a marketplace ... Logo -  http://photos.prnewswire.com/prnh/20140916/146606 Logo -  http://photos.prnewswire.com/prnh/20140916/146607 ...
(Date:9/17/2014)... LEIPZIG, Germany , Sept. 17, ... has entered into an exclusive technology development partnership ... imaging agents to image CD4+ positive immune T ... ImaginAb,s capability to precisely diagnose and determine therapeutic ... areas. The ability to image CD4+ T-cells will ...
(Date:9/17/2014)... , Sept. 17, 2014   GS1 US ... to implement GS1 Standards to support the 2013 ... patient safety and security in the pharmaceutical supply ... Standards to U.S. Pharmaceutical Supply Chain Business Processes ... , was developed in collaboration with GS1 ...
Breaking Medicine Technology:Three Leading Healthcare Organizations Sponsor Conference to Examine Opportunities and Risks of Healthcare Reform for Providers 2ImaginAb Expands ImmunoPET Pipeline to Include CD4+ T-Cell Imaging 2New Healthcare Industry Guideline Delineates How to Implement GS1 Standards to Support Requirements of the 2013 Drug Supply Chain Security Act 2New Healthcare Industry Guideline Delineates How to Implement GS1 Standards to Support Requirements of the 2013 Drug Supply Chain Security Act 3New Healthcare Industry Guideline Delineates How to Implement GS1 Standards to Support Requirements of the 2013 Drug Supply Chain Security Act 4
... TEL-AVIV, Israel , March 15, 2010 Cheetah Medical, a,worldwide leader in noninvasive hemodynamic and cardiac output ... and also included Robert,Bosch Venture Capital (RBVC), MVM Life Science Partners (MVM) and existing,investors. , ... ... ...
... With heart disease continuing to be the No. 1 cause of death in the U.S., Atherotech Inc. has ... company is expanding its disease management services with the goal of helping physicians reduce death and disability from heart disease. ... ... , ...
Cached Medicine Technology:Cheetah Medical Closes $20 Million Series B Financing 2Cheetah Medical Closes $20 Million Series B Financing 3Cheetah Medical Closes $20 Million Series B Financing 4Cheetah Medical Closes $20 Million Series B Financing 5Cheetah Medical Closes $20 Million Series B Financing 6Atherotech Recruits Top Experts in Fight Against Heart Disease 2Atherotech Recruits Top Experts in Fight Against Heart Disease 3Atherotech Recruits Top Experts in Fight Against Heart Disease 4Atherotech Recruits Top Experts in Fight Against Heart Disease 5Atherotech Recruits Top Experts in Fight Against Heart Disease 6
... Swing doors, 8 shelves. Over-sized ... doors. Fluorescent interior lighting. Self-Contained System ... foot cord. Full One Year Warranty on ... Warranty on Compressor. Also available as ...
... Independent controls for Digital Thermostat and Digital ... steel. , Interiorwhite anodized aluminum with ... Oversized refrigeration (134A). , Temperature range ... self-closing doors. , Foamed-in-place polyurethane high ...
... The HC Series Large Capacity Refigerators ... embryos, semen, or biological samples at liquid-nitrogen ... holding times and capacities are available to ... Two low profile HCL models are also ...
... refrigerators from Taylor-Wharton are uniquely designed to ... box-type storage racks and the lower operating ... The RackSystems are available in four convenient ... 750 x 2ml vials to 4800 x ...
Medicine Products: