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Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology Meeting
Date:5/1/2008

r degeneration with 2 million new cases each year. About 21 million people in the United State have diabetes. Of those, 15 million are diagnosed and over 6 million are undiagnosed. Of patients who have had type 1 diabetes for more than 20 years, 50% will have proliferative diabetic retinopathy. Between 60- 80% of type 2 diabetes will manifest retinopathy after 15 years, and 20% will progress to proliferative retinopathy after 25 years of duration.

Although it is not entirely clear what initiates pathological retinal vessel formation in either age-related macular degeneration or diabetic retinopathy, it is clear that aberrant retinal vascularization occurs in a manner not unlike that of other pro-angiogenic pathologies such as cancer. Normally, angiogenesis is kept in check by the body naturally creating angiogenic inhibitors to counteract angiogenic factors. However, this balance appears to be offset in the eye by the production of angiogenic growth factors in excess of the angiogenic inhibitors, thus favoring blood vessel growth. Angiogenic factors made by a variety of ocular cell types bind to the normal retinal or subretinal endothelial cell component of their respective vessels, activating it and inducing endothelial signaling events leading to endothelial cell proliferation forming capillaries, moving outward from the retina. The resulting vessels tend to be leaky, structurally aberrant, inefficient and fragile. These aberrant capillaries induce or promote a variety of pathological conditions including acute loss of vision, hemorrhage, rod and cone degeneration, and retinal detachment resulting in scar formation.

About Paloma Pharmaceuticals

Paloma Pharmaceuticals, Inc. is an early stage drug development company focusing on pathologies with a vascular component including cancer, ocular diseases (macular degeneration and diabetic retinopathy), arthritis, fibrotic diseases (pulmonary fibrosis) endometriosis, osteoporosis and skin diseases (ps
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SOURCE Paloma Pharmaceuticals, Inc.
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