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Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology Meeting
Date:5/1/2008

ogression caused by the growth of pathological retinal vessels, improve current vision damaged by retinal or sub-retinal blood vessels, inhibit retinal fibrosis and finally formulate for long term drug delivery as these ocular diseases are chronic in nature. We have presented data to support each of these issues in our drug Palomid 529. Palomid 529 is a broad inhibitor of angiogenesis able to inhibit the key pro-angiogenic cytokines (via their synthesis and ability to signal) shown to initiate pathological vessel growth in both age-related macular degeneration and diabetic retinopathy. Our data shows Palomid 529's ability to synergize with anti-VEGF antibody treatment and further to actually allow normal vessel growth to occur while concomitantly inhibiting abnormal vessel growth," says Dr. Sherris.

"A frequent complication of retinal detachment is the induction of cell proliferation, often leading to scar formation that can occur on either surface of the retina. When scars form between the epithelial layer and photoreceptors, termed subretinal fibrosis, regeneration of the photoreceptors is compromised resulting in blindness in that region. When scars occur on the vitreal surface, termed proliferative vitreoretinopathy (PVR), the cells become contractile and cause re-detachment of the retina, again resulting in blindness. We show here using an animal model of retinal detachment that a single intravitreal injection of Palomid 529 dramatically reduces the intraretinal proliferation induced by detachment and subsequently reduces subretinal glial scar formation to a degree not found in any other drugs we have evaluated in our models. These findings suggest that inhibiting the Akt/mTOR pathway by Palomid 529 is a promising new strategy for treating subretinal fibrosis and perhaps the related disease, PVR", says Drs. Lewis and Fisher.

About Angiogenesis and Retinal Vascular Diseases

15 million people in the United States alone have age-related macula
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SOURCE Paloma Pharmaceuticals, Inc.
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