Navigation Links
Painkillers May Not Protect Against Dementia
Date:4/22/2009

Contrary to prior research, study finds older people taking NSAIDs more likely to suffer decline

WEDNESDAY, April 22 (HealthDay News) -- Research has suggested that older people who want to avoid Alzheimer's disease might want to take daily doses of painkillers such as ibuprofen and naproxen, but a new study suggests that might not be the best idea.

"If people are thinking, 'Should I take these to prevent dementia?', the answer based on our study would be no," said study author Dr. Eric B. Larson, executive director of the Group Health Center for Health Studies in Seattle.

Still, he said, people who already take medications known as non-steroidal anti-inflammatory drugs (NSAIDs) for pain shouldn't stop using them.

Previous have shown that the drugs -- which also include aspirin, which wasn't included in this study -- seem to have the power to prevent Alzheimer's disease in some cases, although they don't seem to help people who already have the disease or those who develop it quickly.

The relationship between the drugs and Alzheimer's disease appears to be "more complex than was earlier believed," the study authors wrote.

The findings appear in the April 22 online issue of Neurology.

In their study, the Seattle team examined the medical records of more than 2,700 people aged 65 and older who were members of a Washington state medical insurance group as early as 1977. Ninety percent were white.

The researchers checked their usage of NSAIDs and found that 351 were heavy users -- defined as being prescribed at least 500 daily doses over a two-year period -- when they were enrolled in the study. Another 107 started using the medications heavily later on.

The drugs in question include ibuprofen (Advil), naproxen (Aleve) and others.

People who used the drugs extensively were 66 percent more likely to develop dementia than those who didn't, according to statistics that were adjusted to account for the number of participants with certain medical conditions, among other things.

The drugs themselves may not be the problem. Instead, Larson suggested, they could be a sign of chronic medical problems.

"The heavy users [of painkillers] had more diabetes, more arthritis, more signs of heart failure," he said. "It's very likely that what you're seeing is people using these medications because they're beginning to fail in their life."

Dr. Steven Vlad, an epidemiology and rheumatology researcher at Boston University School of Medicine, said the findings are "very much contrary to what a number of other studies have found, and I'm not sure how to fit them into previous research."

In the big picture, he said, "the practical, day-to-day utility of this study is small. We just don't know enough yet."

He agrees with Larson that people should not take the drugs purely to prevent Alzheimer's disease, especially since the medications pose risks of gastrointestinal ulcers, bleeding and kidney disease. "The big issue right now is we don't know how to balance the potential benefits against the known risks," Vlad said.

What to do? Larson said the best strategies to prevent dementia are the usual suspects -- regular exercise, control of blood pressure and no smoking. "These things are really common sense," he said. "Even in late life, they probably do benefit your brain from the standpoint of health."

More information

Learn more about NSAIDs from the American Academy of Orthopaedic Surgeons.



SOURCES: Eric B. Larson, M.D., MPH, executive director, Group Health Center for Health Studies, Seattle; Steven Vlad, M.D., epidemiology and rheumatology researcher, Boston University School of Medicine; April 22, 2009, Neurology, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Post-Op Painkillers Tied to Deaths After Spinal Fusion
2. FDA Warns Drug Makers to Stop Selling Unapproved Prescription Painkillers
3. Labels on OTC Painkillers Need Improvement
4. FDA Seeks Better Regulation of Painkillers
5. Painkillers Linked to Increase in Overdose Deaths
6. Study Sheds Light on Painkillers Heart Risk
7. Common painkillers lower levels of prostate cancer biomarker
8. Study shows doctors offices can help stem abuse of Oxycontin, other narcotic painkillers
9. Painkillers Boost Muscle Mass Among Weight-Training Elderly
10. NSAIDs: Painkillers, inflammation inhibitors, anti-cancer drugs and new de-methylating agents
11. Minorities Less Likely to Get Powerful Painkillers in ER
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Painkillers May Not Protect Against Dementia
(Date:2/11/2016)... ... February 11, 2016 , ... Talix today ... Practice , will be presenting at the 2016 HIMSS Annual Conference & Exhibition, ... , During his session, “ Coding for Care: Using Data Analytics for Risk ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... Be ... new office in the heart of Old Town at 108 South Columbus St, Suite ... businesses the highest level of medical care in the convenience of their homes, offices ...
(Date:2/11/2016)... MA (PRWEB) , ... February 11, 2016 , ... The ... overpaying for IT services, what questions to ask your IT consultant before signing a ... access to your computer network. , “With companies relying heavily on e-mail and technology, ...
(Date:2/10/2016)... Los Angeles, CA (PRWEB) , ... February 10, ... ... Neuro-Linguistic Programming (NLP) practitioner, is known locally for a series of therapeutic sessions ... be in-the-moment in their characters and in their lives. The series, known as ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... company is unveiling its revolutionary new 2.0 version at the International Roofing Expo ... “put the power of the world's most advanced weather technology in the hands ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)...  AcelRx Pharmaceuticals, Inc. (NASDAQ: ACRX ) today ... the 38th annual John A. Boswick , ... being held February 14-18, 2016 in Hawaii ... in wound healing, burn care, and infection control, and ... Burns Association, Academy of Physicians in Wound Care and ...
(Date:2/11/2016)... , Feb. 11, 2016  NanoViricides, Inc. ... it has entered into an agreement with the ... nanoviricides® drug candidates in standard animal models of ... , Research Director. Dr. Romanowski has extensive experience ... --> Eric Romanowski , Research ...
(Date:2/11/2016)... Israel , Feb. 11, 2016  Galmed Pharmaceuticals Ltd. ... company focused on the development of a once-daily, oral ... that its Chief Medical Officer, Dr. Maya Halpern ... Galmed as Chief Medical Officer and from its Board ... to her reaching retirement age. Allen Baharaff ...
Breaking Medicine Technology: