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Painkillers May Halve Risk of Breast Cancer Return in Obese Women: Study
Date:8/14/2014

he key reasons that obese women do worse on hormone therapy is because of inflammation induced by obesity," deGraffenried said. Reducing the inflammation with aspirin and other NSAIDs, she explained, may improve how well the hormone therapies work.

However, deGraffenried noted, it's too soon to recommend taking NSAIDs for reducing either breast cancer recurrence or development. And while the researchers found an association between NSAID use and a reduced risk of breast cancer recurrence, the study was not designed to prove cause and effect.

Also, painkillers have side effects, she added, such as a risk of gastrointestinal bleeding.

If future research bears out the latest findings, deGraffenried said, giving women with estrogen receptor-positive breast cancer a daily NSAID may reduce or delay the return of the breast cancer, and possibly spare them from needing additional treatments.

The concept makes sense, said Leslie Bernstein, director of the division of cancer etiology at the Beckman Research Institute of the City of Hope Cancer Center in Duarte, Calif. Bernstein is a longtime breast cancer researcher.

"We think of obesity as an inflammatory condition, and women who are obese have a higher risk of recurrence," she said. (In her own research, she has found that higher risk occurs in white, but not black, women.) It does make sense, she said, that aspirin would reduce inflammation and thus the risk of recurrence.

However, the study has some limitations, Bernstein noted. It relies on chart reviews, for instance, not direct interviews with the women. It would also have been valuable to look at aspirin alone, she added, rather than a variety of NSAIDs.

Bernstein agreed more work should be done, including clinical trials to focus on aspirin. If the research continues to bear out, she said, a recommendation to take a daily aspirin might help reduce recurrence of breast cancer.

This preventive measure might be adhered t
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Painkillers May Halve Risk of Breast Cancer Return in Obese Women: Study
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