Navigation Links
Pain reliever shows anti-viral activity against flu
Date:3/21/2013

The over-the-counter anti-inflammatory drug naproxen may also exhibit antiviral activity against influenza A virus, according to a team of French scientists. The finding, the result of a structure-based investigation, is published online ahead of print in the journal Antimicrobial Agents and Chemotherapy.

New influenza vaccines must be developed annually, because the surface proteins they target mutate rapidly, the way cars used to get a whole new look every year. The researchers, led by Anny Slama-Schwok of the Institut National de la Recherche Agronomique, Jouy en Josas, France, found a much more stable, reliable target for anti-influenza activity. The so-called ribonucleoprotein complexes are necessary for replication, and the researchers realized they could target the nucleoprotein, preventing assembly of the complexes. Because of its vital function, the nucleoprotein is highly conserved, making it a good potential target for antiviral drugs.

The nucleoprotein's three dimensional structure, solved in 2006, provided the basis for searching for new drugs that could interfere with its action. The researchers did a virtual screening within the Sigma-Aldrich online catalog of biochemicals. That screening identified Naproxen, better known as the over-the-counter pain reliever Aleve, and as expected, it bound to the nucleoprotein, and impeded RNA binding, says Slama-Schwok. In further testing, it reduced the viral load in cells infected with H1N1 and H3N2 influenza A virus, and in mice it demonstrated a therapeutic index against influenza A that was superior to that of any other anti-inflammatory drug.

Specifically, naproxen blocks the RNA binding groove of the nucleoprotein, preventing formation of the ribonucleoprotein complex, thus taking the vital nucleoproteins out of circulation. The researchers write that naproxen is a lead compound for drug development that could be improved by tweaking the molecule to boost its ability
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers explore connection between popular pain relievers, bladder cancer
2. Wellesley study shows income inequality a key factor in high US teen births
3. Invasive heart test being dramatically overused, Stanford study shows
4. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
5. Lung Cancer Screening Might Pay Off, Analysis Shows
6. Nonsurgical Method to Measure Brain Pressure Shows Promise
7. BMC study shows diverting passengers to elevators could help reduce falls at Logan Airport
8. Study Shows New Option for Kids With Tough-to-Treat Leukemia
9. Politics May Get in the Way of Empathy, Research Shows
10. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
11. Experimental Pill for Multiple Sclerosis Shows Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... moving too,slowly in reducing maternal deaths, enabling young people ... experts, advocates and,activists agreed today., Existing commitments and ... other reproductive health challenges, according to An Open,Letter to ... here., Some 1,300 people from civil society and ...
... 31, 2007 Today researchers report a newly ... of prostate cancer in African American men. This ... associated with prostate cancer in high-risk populations, is published ... , Prostate cancer is the second leading cause of ...
... have same benefit for Caucasians , , WEDNESDAY, Oct. 31 ... experimental chemotherapy drug after surgery improved survival rates for ... of the trial won,t mean much for Americans with ... as "investigational" in the United States. But the study ...
... 31 An influential report on,cancer prevention provides ... policy, say doctors with the Physicians Committee for,Responsible ... the American,Institute for Cancer Research (AICR). A comprehensive ... previous research showing that meat and,alcohol consumption increase ...
... 31 /PRNewswire-FirstCall/ - Haemacure Corporation,(TSX:HAE), a specialty bio-therapeutics ... Acumen BioFin Rodman & Renshaw 9th Annual,Healthcare Conference, ... the New York,Palace Hotel in New York. ... of the presentation and,post the associated slides via ...
... Silicon Valley Marathon and Expo, Who: Lifespring Health ( http://www.lifespringhealth.com ) offers ... to help people afford a healthy lifestyle ... Silicon Valley Marathon. The run is set in San Jose and is a ... Expo -- Saturday 11/3 from 10 am - 4 pm ...
Cached Medicine News:Health News:Diverse Partners Renew Commitment to Reproductive Health, Rights in Asia 2Health News:Diverse Partners Renew Commitment to Reproductive Health, Rights in Asia 3Health News:Scientists discover genetic variant associated with prostate cancer in African Americans 2Health News:Chemo Drug Improves Stomach Cancer Survival for Japanese Patients 2Health News:Just-Released Cancer Report Provides New Ammunition for Farm Bill Reform Effort 2Health News:Haemacure announces webcast of presentation at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conferencec 2
(Date:12/24/2014)... Dec. 24, 2014 /PRNewswire/  -- Tianyin Pharmaceutical Inc. ... company that specializes in the patented biopharmaceutical, modernized ... pharmaceutical ingredients (API) released unaudited preliminary financial results ... Fiscal Year 2015 Ended September 30, ... million compared with $14.7 million in 1Q14 with ...
(Date:12/24/2014)... Trade Commission (ITC) issued its final decision in the case ... issued on December 23, the ITC ruled in favor of ... invalid. BMC President, James Xu called ... the ITC,s decision in this case. This victory for us ... beginning on the key patents in the case. ResMed chose ...
(Date:12/24/2014)... CRANBURY, N.J. and FARMINGTON, ... Palatin Technologies, Inc. (NYSE MKT: PTN), a biopharmaceutical ... treatment of diseases with significant unmet medical need ... closed on a private placement of 2,050,000 shares ... to purchase 24,949,325 shares of its common stock.  ...
Breaking Medicine Technology:TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4
... (PDL) (NASDAQ: PDLI ) today announced revenue guidance ... $72 million, as compared with actual results of $76 million ... Total anticipated revenue for the year ended December 31, 2011 ... million for the year ended December 31, 2010, a five ...
... & Leviton LLP is investigating whether the Board of ... (NASDAQ: ISTA ) breached their fiduciary duties ... ("Valeant") (NASDAQ: VRX ) to acquire the ... The investigation centers on whether ISTA,s ...
Cached Medicine Technology:PDL BioPharma Provides Fourth Quarter 2011 Revenue Guidance of $72 Million 2PDL BioPharma Provides Fourth Quarter 2011 Revenue Guidance of $72 Million 3PDL BioPharma Provides Fourth Quarter 2011 Revenue Guidance of $72 Million 4
Traditional design utility pliers have adjustable jaws. Good all purpose plier for handling Steinmann Pins, K-Wires, screws and rods. 10mm jaw tip....
The Wire Cutters are designed to cut Kirschner wires up to 2.5 mm diameter easily and smoothly. They are particularly useful for external fixation applications. The Wire Cutters shear fixation wires ...
Curved osteotome for bone removing....
... Spectral system is a combination Spectral Optical ... (SLO) system that provides suberb, high-quality images ... With the advancements of spectral technology, OTI's ... to 27,000 A-Scans per second and provide ...
Medicine Products: