Navigation Links
Pain receptor in brain may be linked to learning and memory
Date:3/13/2008

PROVIDENCE, R.I. [Brown University] Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body. Now a group of Brown University scientists has found that these receptors a darling of drug developers also may play a role in learning and memory in the brain.

In surprising new research, published in the journal Neuron, Julie Kauer and her team show that activation of TPRV1 receptors can trigger long-term depression, a phenomenon that creates lasting changes in the connections between neurons. These changes in the brain and the related process of neural reorganization known as long-term potentiation are believed to be the cellular basis for memory making.

Weve known that TRPV1 receptors are in the brain, but this is some of the first evidence of what they actually do there, Kauer said. And the functional role we uncovered is unexpected. No one has previously linked these pain receptors to a cellular mechanism underlying memory. So we may have found a whole new player in brain plasticity.

The study findings have implications for drug development, Kauer said.

The research points out potentially effective new targets for drugs that could prevent memory loss or could possibly treat neural disorders such as epilepsy, Kauer said. The other implication may be cautionary. Drug makers already sell drugs such as the weight-loss pill rimonabant, which is sold in Europe under the name Acomplia that can block TRPV1 receptors. Other drugs aimed at reducing pain and inflammation by blocking or activating TRPV1 receptors are in the research pipeline. But drugs that bind to TRPV1 receptors in the central nervous system are likely to influence more than just pain-related functions, Kauer said.

Our findings suggest the possibility that some of the psychiatric side effects from rimonabant could be due to the blocking of TRPV1 receptors, she said.

TRPV1, short for transient receptor potential vanilloid subtype, can be found all over the nervous system, including in skin, the spinal cord and the brain. These receptors can sense heat, trigger inflammation and transmit pain. TRPV1 receptors not only respond to heat but also to capsaicin, the compound that creates the spicy kick in chili peppers.

In her study, Kauer, professor of medical science in the Department of Molecular Pharmacology, Physiology and Biotechnology at Brown, treated rat brain tissue from the hippocampus, the brains seat of learning and memory, with capsaicin. The team found that this compound activated TRPV1 channels which alone triggered long-term depression in the brain tissue. Further, rimonabant entirely blocked long-term depression by blocking TRPV1 channels.

The team then tested brain tissue from mice that lacked TRPV1 receptors and found that long-term depression was absent and that applying capsaicin still couldnt elicit the changes to the synapses.


'/>"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Related medicine news :

1. Cell Receptor on Track for Painless Bladder Cancer Test
2. Scientists determine structure of brain receptor implicated in epilepsy and PMT
3. Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators
4. NIAID scientists identify new cellular receptor for HIV
5. Food peptides activate bitter taste receptors
6. Cell-death receptor links cancer susceptibility and inflammation
7. Receptor protein appears to be key in breakdown of kidney filtration
8. Exelixis to Receive Milestone Payment From Bristol-Myers Squibb for Achievement of Liver X Receptor Agonist Development Milestone
9. Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
10. Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
11. Food restriction increases dopamine receptor levels in obese rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... PA and London UK (PRWEB) , ... March ... ... the speed, agility and ability to gain site attention and engagement over the ... DrugDev educational webinar will discuss how partnering with the right ...
(Date:3/27/2017)... ... March 27, 2017 , ... A study by the founder of ... colleague, Sudeep Roy, MD, was recently published in the American Journal of Cosmetic ... details Drs. Buckingham and Roy’s study on the use of Electro Lube during the ...
(Date:3/27/2017)... Arizona (PRWEB) , ... March 27, 2017 , ... Buzzies ... the top 10 for Rent the Runway Foundation and UBS’ Project Entrepreneur. Mayo will ... York on April 8. , Project Entrepreneur’s second annual venture competition ignites bold ...
(Date:3/27/2017)... IL (PRWEB) , ... March 27, 2017 , ... ... systems, recently received the CE Certificate of Conformity for the Smart System® 20/20. ... or exceed the highest industry standards and specifications such as ANSI, ISO and ...
(Date:3/27/2017)... ... March 27, 2017 , ... American ... conference coverage on veterinary medicine, announces the launch of Veterinarian’s Money Digest™, a ... with the April edition of American Veterinarian™. , “We look forward ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 27, 2017  Sanderling Ventures, portfolio company, Torax ... division of Johnson & Johnson. Torax manufactures and markets ... of gastro-esophageal reflux disease (GERD). The LINK device ... and the procedure is currently available in the ... Medical was founded by Sanderling Ventures, Mayo Medical ...
(Date:3/27/2017)... March 27, 2017 BioLineRx Ltd. (NASDAQ/TASE: ... announced today that AGI-134, an immunotherapy for the treatment of ... Ltd., will be featured at the upcoming American Association ... Washington, DC to be held on April 1-5, ... ...
(Date:3/27/2017)... FRANCISCO , March 27, 2017 ... expected to reach USD 16.0 billion by 2025, according ... The growing prevalence of chronic diseases is anticipated to ... chemistry analyzers, which thereby widens the scope for growth ... geriatric and bariatric population, which is highly susceptible to ...
Breaking Medicine Technology: