Navigation Links
Pain processes in tennis elbow illuminated by PET scanning
Date:10/28/2013

Physiological processes in soft tissue pain such as chronic tennis elbow can be explored using diagnostic imaging methods. This is demonstrated by researchers from Uppsala University and the results are now being published in the prestigious journal PLOS ONE. The pain physician and researcher Magnus Peterson is presenting a new use of positron emission tomography (PET) and a tracer for the signal receptor NK1 for visualising a physiological process associated with pain.

Chronic pain is a major problem, with considerable socioeconomic costs and suffering of the individual. Musculoskeletal pain is the most common type of pain and is one of the most common reasons for consultation in health care. However, pain from soft tissues, (i.e. pain from muscles, tendons and ligaments) is still lacking effective methods for localization and diagnosis of underlying pathophysiological mechanisms.

This means that diagnosis still depends on clinical examination, which provides no guidance regarding what mechanisms might underlie the pain. Consequently, treatment proceeds purely on an empirical basis. An improved diagnostic method that allows not only diagnosis of localisation of the painful tissue processes, but also can provide guidance regarding what pathophysiological mechanisms are involved, would therefore be highly valuable.

Magnus Peterson has worked with positron emission tomography (PET), a tool for diagnostic imaging, in combination with a specific tracer for the signal receptor NK1. The tracer is injected into the blood where it circulates through the body and binds to available NK1 receptors. The signal from the radioactive tracer can then be captured as an image outside the body using PET.

This is the first time an up-regulation of NK1 receptors has been visualized by diagnostic imaging in painful tissue in humans. The study clearly reveals an image of elevated levels of NK1 in the painful area compared with the healthy arm.

Following tissue damage there is an up-regulation of the neuropeptide substance P and its receptor NK1. This occurs not only in the dorsal horn of the spinal cord, but also in the peripheral painful tissue. This up-regulation is part of an interaction between peripheral nerves, immune cells, and the tissue itself that seems to help guide the body's own repair process. In chronic tennis elbow, this up-regulation of the substance P-NK1 system lingers on. This is what the researchers have managed to visualize with the help of PET and the marker for NK1.

The method is promising, but the costs are still high. PET is a complicated procedure, which requires costly equipment.

- In the future, we hope to be able to develop less expensive markers that enable us to use the method in everyday clinical practice. We also aim to create markers for other physiological processes that we know are active in chronic soft tissue pain, says Magnus Peterson.


'/>"/>

Contact: Magnus Peterson
magnus.peterson@pubcare.uu.se
46-070-288-2768
Uppsala University
Source:Eurekalert  

Related medicine news :

1. New technique reveals cross-talk between 2 essential cellular processes
2. Study offers new clue on how brain processes visual information
3. Enzymes implicated in disease processes attack one another instead of harming body proteins
4. The City of Whitehouse, Texas Automates Its Timekeeping Processes with NOVAtime 4000 System and State-of-the-Art NT450 Time Clocks
5. Global Epicor Customer Conferences Bring Collaboration on Best Practices in Technology Solutions, Including Altec’s doc-link to Automate Business Processes
6. Alfresco Workdesk Streamlines Document-Centric Business Processes
7. Cascade Gasket Utilizes the NOVAtime 4000 SaaS Workforce Management System to Manage Business Processes in Real-Time
8. Remembering to remember supported by 2 distinct brain processes
9. Brightree and ResMed Announce Electronic Purchasing Agreement to Promote Streamlined Ordering Processes for HME Customers
10. Steroid Shots for Tennis Elbow Miss the Mark: Study
11. Mission Hills Tennis Club to Host Spring Break Nike Tennis Camp
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pain processes in tennis elbow illuminated by PET scanning
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... Multiple award ... been family-owned and operated for over 35 years. Maintaining core values of exceptional customer ... their success and made them a leading name in San Diego plumbing, and other ...
(Date:5/6/2016)... ... May 06, 2016 , ... In honor ... education and corporate training, and the National Military Family Association, a nonprofit that ... as the second full-tuition scholarship recipient of 2016. , “Being awarded this ...
(Date:5/6/2016)... ... 2016 , ... “ Crossing Over: Affirmations of Faith in the Midst of ... allowed those holding vigil to glimpse into the supernatural as their lives ended. With ... spiritually and practically gain insight into providing care to terminal patients. , “I ...
(Date:5/5/2016)... ... May 05, 2016 , ... While the practice and profession ... the impact our aging population has on communities and resources. Aging Life Care plays ... and face age-related challenges. , Aging Life Care is a holistic, client-centered approach ...
(Date:5/5/2016)... ... May 05, 2016 , ... Textile Exchange is excited ... for public stakeholder review. The stakeholder review is an important opportunity for interested parties ... and delivers value to the wool industry., The RWS is intended to be a ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 4, 2016  Compass Diversified Holdings (NYSE: ... owner of leading middle market businesses, announced today its ... 31, 2016. First Quarter 2016 Highlights ... ("CAD" or "Cash Flow") of $13.6 million for the ... of $15.0 million for the first quarter of 2016; ...
(Date:5/4/2016)... Yissum Research Development Company ... that it had signed an exclusive world-wide licensing and ... novel protein degradation and immunomodulatory drugs for cancer and ... candidates representing first-in-class therapy for hematologic and solid malignancies. ... The novel technology was developed by Yinon ...
(Date:5/4/2016)... 2016 Research and ... Acute Myeloid Leukemia Market and Competitive Landscape ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... and Competitive Landscape Highlights 2016, provides comprehensive ... Acute Myeloid Leukemia epidemiology, Acute Myeloid Leukemia ...
Breaking Medicine Technology: