Navigation Links
Pain processes in tennis elbow illuminated by PET scanning

Physiological processes in soft tissue pain such as chronic tennis elbow can be explored using diagnostic imaging methods. This is demonstrated by researchers from Uppsala University and the results are now being published in the prestigious journal PLOS ONE. The pain physician and researcher Magnus Peterson is presenting a new use of positron emission tomography (PET) and a tracer for the signal receptor NK1 for visualising a physiological process associated with pain.

Chronic pain is a major problem, with considerable socioeconomic costs and suffering of the individual. Musculoskeletal pain is the most common type of pain and is one of the most common reasons for consultation in health care. However, pain from soft tissues, (i.e. pain from muscles, tendons and ligaments) is still lacking effective methods for localization and diagnosis of underlying pathophysiological mechanisms.

This means that diagnosis still depends on clinical examination, which provides no guidance regarding what mechanisms might underlie the pain. Consequently, treatment proceeds purely on an empirical basis. An improved diagnostic method that allows not only diagnosis of localisation of the painful tissue processes, but also can provide guidance regarding what pathophysiological mechanisms are involved, would therefore be highly valuable.

Magnus Peterson has worked with positron emission tomography (PET), a tool for diagnostic imaging, in combination with a specific tracer for the signal receptor NK1. The tracer is injected into the blood where it circulates through the body and binds to available NK1 receptors. The signal from the radioactive tracer can then be captured as an image outside the body using PET.

This is the first time an up-regulation of NK1 receptors has been visualized by diagnostic imaging in painful tissue in humans. The study clearly reveals an image of elevated levels of NK1 in the painful area compared with the healthy arm.

Following tissue damage there is an up-regulation of the neuropeptide substance P and its receptor NK1. This occurs not only in the dorsal horn of the spinal cord, but also in the peripheral painful tissue. This up-regulation is part of an interaction between peripheral nerves, immune cells, and the tissue itself that seems to help guide the body's own repair process. In chronic tennis elbow, this up-regulation of the substance P-NK1 system lingers on. This is what the researchers have managed to visualize with the help of PET and the marker for NK1.

The method is promising, but the costs are still high. PET is a complicated procedure, which requires costly equipment.

- In the future, we hope to be able to develop less expensive markers that enable us to use the method in everyday clinical practice. We also aim to create markers for other physiological processes that we know are active in chronic soft tissue pain, says Magnus Peterson.


Contact: Magnus Peterson
Uppsala University

Related medicine news :

1. New technique reveals cross-talk between 2 essential cellular processes
2. Study offers new clue on how brain processes visual information
3. Enzymes implicated in disease processes attack one another instead of harming body proteins
4. The City of Whitehouse, Texas Automates Its Timekeeping Processes with NOVAtime 4000 System and State-of-the-Art NT450 Time Clocks
5. Global Epicor Customer Conferences Bring Collaboration on Best Practices in Technology Solutions, Including Altec’s doc-link to Automate Business Processes
6. Alfresco Workdesk Streamlines Document-Centric Business Processes
7. Cascade Gasket Utilizes the NOVAtime 4000 SaaS Workforce Management System to Manage Business Processes in Real-Time
8. Remembering to remember supported by 2 distinct brain processes
9. Brightree and ResMed Announce Electronic Purchasing Agreement to Promote Streamlined Ordering Processes for HME Customers
10. Steroid Shots for Tennis Elbow Miss the Mark: Study
11. Mission Hills Tennis Club to Host Spring Break Nike Tennis Camp
Post Your Comments:
Related Image:
Pain processes in tennis elbow illuminated by PET scanning
(Date:11/27/2015)... ... 2015 , ... An inventor, from Hopkinsville, Ky., thought there ... home, so he invented the patent-pending ELECTRONIC M.D. , The ELECTRONIC M.D. provides ... so, it could help to prevent potential overdose situations. As a result, it ...
(Date:11/27/2015)... Aliso Viejo, CA (PRWEB) , ... November 27, 2015 , ... ... exclusively for use in Final Cut Pro X. With ProSidebar: Fasion, video editors ... banners, or use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television ... an interesting show that delves into an array of issues that are presently affecting ... benefit from open dialogue, this show is changing the subjects consumers focus on, one ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and ... nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown commitment ... advance the healthcare industry as a whole through their advocacy and professional efforts. ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 2015  Lannett Company, Inc. (NYSE: LCI ... acquisition of Kremers Urban Pharmaceuticals Inc. (KU), the ... company UCB S.A. (Euronext: UCB). ... KU from UCB for total consideration of approximately ... customary working capital adjustment, a deduction of certain ...
(Date:11/27/2015)... 26, 2015 ... the "2016 Global Tumor Marker Testing ... and Sales Segment Forecasts, Innovative Technologies, Instrumentation ... to their offering. --> ... "2016 Global Tumor Marker Testing Market: ...
(Date:11/26/2015)... Un nuevo enfoque combina la ... cáncer avanzado.   --> Un nuevo ... Bremachlorin para el cáncer avanzado.   --> ... la terapia fotodinámica de Bremachlorin para el cáncer avanzado. ... --> Clinical Cancer Research . --> ...
Breaking Medicine Technology: