Navigation Links
Pain in fibromyalgia is linked to changes in brain molecule
Date:3/10/2008

ANN ARBOR, Mich. Researchers at the University of Michigan Health System have found a key linkage between pain and a specific brain molecule, a discovery that lends new insight into fibromyalgia, an often-baffling chronic pain condition.

In patients with fibromyalgia, researchers found, pain decreased when levels of the brain molecule called glutamate went down. The results of this study, which appears in the journal Arthritis and Rheumatism, could be useful to researchers looking for new drugs that treat fibromyalgia, the authors say.

If these findings are replicated, investigators performing clinical treatment trials in fibromyalgia could potentially use glutamate as a surrogate marker of disease response, says lead author Richard E. Harris, Ph.D., research assistant professor in the Division of Rheumatology at the U-M Medical School's Department of Internal Medicine and a researcher at the U-M Chronic Pain and Fatigue Research Center.

The molecule glutamate is a neurotransmitter, which means it conveys information between neurons in the nervous system. When glutamate is released from one neuron, it diffuses across the space between cells, and then binds to receptors on the next neuron in line and causes the cell to become excited, or to be more active.

This molecule was suspected to play a role in fibromyalgia because previous studies had shown that some brain regions in fibromyalgia patients appear to be highly excited. One such region is the insula.

In functional magnetic resonance imaging (fMRI) studies, researchers at U-M had previously shown that the insula displays augmented activity in fibromyalgia, which means neurons in these patients are more active in this part of the brain. The U-M team hypothesized, Harris notes, that more activity among these neurons might be related to the level of glutamate in this region.

To gauge the linkage between pain and glutamate, the researchers used a non-inva
'/>"/>

Contact: Katie Vloet
kgazella@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Aquatic Exercises May Ease Fibromyalgia
2. Exercise Eases Fibromyalgia Symptoms: Study
3. Effective Treatment for Fibromyalgia Featured on Oprah Winfrey Show You Dont Have to Live With That Agony!
4. Medialink Features: The Painful Truth About Fibromyalgia
5. Frances Winfield Bremer, Wife of Ambassador L. Paul Bremer, III, to Become Spokeswoman for the National Fibromyalgia Association
6. Why dont painkillers work for people with fibromyalgia?
7. Consumer Reports Analysis: Drugs for Nerve Pain, Fibromyalgia Effective, But Not Always Best
8. Government Assistance Linked to Better Child Development
9. Brain network linked to contemplation in adults is less complex in children
10. Low micro-RNA level linked to high gene activity in AML
11. Einstein researchers discover gene mutations linked to longer lifespans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... May 07, 2015 A poker run to raise ... May 30. , The poker run will start at the United ... p.m. , During the poker run, participants will visit checkpoints, ... the best poker hand at the end of the run. The ... 172 miles to York Offsides Tavern, Fairmont American Legion, Hastings DAV ...
(Date:5/6/2015)... New Standards for Excipient GMPs:, ... May 27, 2015 — 1:30 p.m. – 3:00 ... contain 70-90% excipients, which serve as taste-maskers, glidants, ... that facilitate the manufacturing process and improve chemical ... with a regulatory focus on preventing counterfeits and ...
(Date:5/6/2015)... Device Patent Law Changes:, Six Key Areas of ... 12:30 p.m. EDT, http://www.fdanews.com/DevicePatentLaw , Every year, medical ... claims that waste their time. , It doesn't have ... prevented if devicemakers better understand the trouble spots to watch ... to patent laws from all around the world. , Why ...
(Date:5/6/2015)... With recent headlines about the kidnapping of Bossini clothing store ... Southern China, it is becoming apparent to people all over ... This is especially true for High Net Worth Individuals and ... the property they own, the schools their children attend or ... families and companies that are at higher risk than most ...
(Date:5/6/2015)... NASHVILLE, Tenn. (PRWEB) May 06, 2015 ... is open for the Game Changers Summit 2015 ... ) conference hosted by United Methodist Communications. Join the ... in Nashville when technology and communication leaders from around ... strategy to aid social good throughout the developing world. ...
Breaking Medicine News(10 mins):Health News:Updated Contacts: Poker Run Fundraiser to Benefit National Veterans Golden Age Games 2Health News:FDAnews Announces — New Standards for Excipient GMPs: Analyzing the Impact of NSF/IPEC/ANSI 363-2014 Webinar, May 27, 2015 2Health News:FDAnews Announces — New Standards for Excipient GMPs: Analyzing the Impact of NSF/IPEC/ANSI 363-2014 Webinar, May 27, 2015 3Health News:FDAnews Announces — Device Patent Law Changes: Six Key Areas of Concern Webinar, May 27, 2015 2Health News:FDAnews Announces — Device Patent Law Changes: Six Key Areas of Concern Webinar, May 27, 2015 3Health News:Pacific Prime China Now Offering Kidnapping & Ransom Insurance 2Health News:Second Annual Game Changers Summit Offers ICT4D Workshops to 'Harness Power of Technology for Global Good' 2Health News:Second Annual Game Changers Summit Offers ICT4D Workshops to 'Harness Power of Technology for Global Good' 3
... twice before buying their next pair of high-heels or pumps, ... Hebrew SeniorLife in a new study of older adults and ... women wear, specifically high-heels, pumps and sandals, may cause future ... who reported hind-foot pain regularly wore these types of shoes ...
... individuals from the field of pharmaceutical research are expected to ... - 12, 2009 at the Los Angeles Convention Center in ... have the opportunity to present new research, methods and technologies ... only is the meeting the premiere international event for the ...
... ... healthcare professionals, today announced that it has acquired the assets of Medical Concepts Staffing ... , ... (PRWEB) September 28, 2009 -- Temps Inc., ( www.tempsinc.net ) a national provider of ...
... cons of cancer screen not understood, research shows, , MONDAY, ... told the pros and cons of PSA tests, two new ... they can,t predict which cancers are aggressive and which are ... leads to overtreatment, which can have immediate consequences, such as ...
... cells to ignore premature signals to stop producing important proteins. ... Journal of Experimental Medicine , the findings could lead to ... dystrophy, that are sparked by missing proteins. "When DNA ... than the end of a protein-producing signal, they act like ...
... of Common Human Disease has been chosen as one ... of Health (NIH) grant for Centers of Excellence to ... million over five years. "We,re grateful for ... how epigenetic control affects disease," says the center,s director, ...
Cached Medicine News:Health News:Institute for Aging Research study links high-heels to heel and ankle pain 2Health News:Temps Inc. Acquires Medical Concepts Staffing Business From Analysts International Corporation 2Health News:Men Not Being Told Enough About PSA Tests 2Health News:Men Not Being Told Enough About PSA Tests 3Health News:Men Not Being Told Enough About PSA Tests 4Health News:UCLA study identifies 2 chemicals that could lead to new drugs for genetic disorders 2
(Date:5/6/2015)... Johnson & Johnson (NYSE: JNJ ) ... party to review requests made to the Janssen Pharmaceutical ... compassionate use of its investigational medicines. This new approach ... single Janssen investigational medicine and, if successful, will become ... Johnson & Johnson. In keeping with the ...
(Date:5/6/2015)... 6, 2015  Zimmer Holdings, Inc. (NYSE and SIX: ZMH), ... will be presenting at the Bank of America Merrill Lynch ... Las Vegas, Nevada on Wednesday, May ... live webcast of the presentation can be accessed via Zimmer,s ... be archived for replay following the conference. About ...
(Date:5/6/2015)... NEW YORK , May 6, 2015  The ... ("GEVA" or the "Company") by Alexion Pharmaceuticals, Inc. ("Alexion") ... action, shareholder rights law firm, for possible breaches of ... Board of Directors of GEVA for agreeing to sell ... Company announced a definitive agreement for Alexion to acquire ...
Breaking Medicine Technology:Johnson & Johnson Announces NYU School of Medicine Partnership To Evaluate Compassionate Use of Investigational Medicines 2Johnson & Johnson Announces NYU School of Medicine Partnership To Evaluate Compassionate Use of Investigational Medicines 3Johnson & Johnson Announces NYU School of Medicine Partnership To Evaluate Compassionate Use of Investigational Medicines 4Johnson & Johnson Announces NYU School of Medicine Partnership To Evaluate Compassionate Use of Investigational Medicines 5WeissLaw LLP Investigates the Synageva Biopharma Corp. Acquisition 2
... Neuralstem, Inc. (NYSE Amex: CUR ) announced ... trial to test its neuroregenerative small molecule drug, NSI-189, in ... the drug in healthy volunteers for safety and tolerability. Phase ... will test the safety and tolerability of NSI-189 in depressed ...
... Since its initial inception, Echosens has ... and strengthen its product range with the recent introduction ... Equipped with a new and more ergonomic tactile interface, ... latest FibroScan ® provides a reliable, accurate and ...
Cached Medicine Technology:Neuralstem Completes Phase Ia in Neuroregenerative Small Molecule Drug, NSI-189, Major Depressive Disorder Trial 2Neuralstem Completes Phase Ia in Neuroregenerative Small Molecule Drug, NSI-189, Major Depressive Disorder Trial 3Echosens: Launch of the FibroScan®502 Touch 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: