Navigation Links
Pain-free microneedle influenza vaccine is effective, long-lasting
Date:9/4/2013

Scientists have developed an influenza vaccine delivered via microneedle patch that provided 100 percent protection against a lethal influenza virus in mice more than one year after vaccination. They report their findings in the September 2013 issue of the journal Clinical and Vaccine Immunology.

Microneedles are a medium for delivery of influenza vaccine that avoids the pain associated with ordinary hypodermic needles. They are a mere seven tenths of a millimeter in length, and the volume of vaccinea major contributor to painis minuscule.

Instead of a liquid containing whole killed or attenuated virus, this vaccine uses dry virus-like particles (VLPs) which simply coat the needles in the presence of a simple stabilizing agent, reducing the need for refrigeration a potential boon for use in developing countries. The lower dose required when using microneedles also reduces the potential for side effects, such as lung inflammation.

"This method can induce higher levels of IgG2a antibodies as well as rapid recall immune responses following lethal challenge infection. Our previous study showed that microneedle vaccination induced higher levels of antibody-secreting cells in spleen and bone marrow compared to intramuscular vaccination," says Sang-Moo Kang of Georgia State University, a researcher on the study.

Earlier studies by this group showed that influenza VLP-coated microneedles actually produced higher short-term protection than conventional intramuscular immunization. In this study the researchers tested how effective the long-term protection of the vaccine was. Mice that received the vaccine were 100 percent protected from a lethal challenge with the influenza virus 14 months after vaccination.

Kang says his aim was to develop an easier and pain-free method of vaccine delivery. He also says that patients could probably use this system to vaccinate themselves.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. Highlands Ranch, CO Cosmetic Dentist Dr. Michael R. Varley Introduces Treatment for Pain-Free Dentistry
2. Queens Dentist Now Offers DentalVibe to Make Dental Implants Pain-Free
3. Dr. Doron Keren, Port Washington Dentist, Introduces New Pain-Free Dental Cleaning Technology
4. With the Launch of Dr-Pain.com, the Become Pain-free Doctor Network Continues Expansion with Top Pain Management Doctors and Spine Surgeons
5. Measles vaccine given with a microneedle patch could boost immunization programs
6. Research shows potential of microneedles to target therapeutics to the back of the eye
7. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
8. Joint Study Sheds New Light on the Cause of Pandemic Influenza
9. Behavior change may have the greatest influence on waves of influenza outbreak: McMaster study
10. New study describes imaging findings in H7N9 influenza
11. Ferrets, pigs susceptible to H7N9 avian influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... Los Angeles, CA (PRWEB) , ... February 21, 2017 , ... ... the available data on gastric balloons for weight loss. It found that the treatments ... the efforts of obese patients, when compared to unassisted efforts. It also noted very ...
(Date:2/20/2017)... ... ... Nancy Johnston Toll marks her debut in the publishing scene with ... the Road ” (published by Xlibris). Inspired from her personal experiences, this compendium abounds ... downs experienced by anyone going through cancer treatment and how one can be a ...
(Date:2/20/2017)... ... ... Researchers at the University of Pittsburgh School of Medicine have uncovered a ... response to a particular class of drugs, not just in patients with thyroid cancer, ... were published in Proceedings of the National Academy of Science. , “These results further ...
(Date:2/20/2017)... ... 2017 , ... Best Doctors® and IBM today announced that ... that want to help members of their workforce battling cancer. Through the Best ... suite of oncology offerings for insights on cancer treatment options, ranging from standard ...
(Date:2/20/2017)... , ... February 20, 2017 , ... ... care providers and health plan partners, announced during the 2017 Annual HIMSS ... enhancing care coordination for diabetic patients and integrating eye care into mainstream ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Diabetic Shoes Market: Overview Read the ... ... disease, which is marked by high levels of blood glucose ... disease has become a global epidemic leading to serious complications ... of the body including eyes, kidneys, heart. However, it has ...
(Date:2/21/2017)... Feb. 21, 2017  Global health services company Cigna ... ® for breast reconstruction surgery and Dermacell ... an advanced acellular dermal matrix developed by LifeNet Health ... NVDQ ) "We are proud ... health-care payers to review the growing base of evidentiary ...
(Date:2/21/2017)... Feb. 21, 2017 ... a new imaging solution that connects Lexmark multifunction printers ... of the world,s leading scanning and indexing software solutions ... enables hospitals to use a Lexmark MFP at the ... Solarity workflow, helping facilities reach HIMSS Stage 7 ...
Breaking Medicine Technology: