Navigation Links
Pacemaker tune-up works chemical wonders on damaged hearts in dogs
Date:3/5/2008

lls from dying, an enzyme called phospho-BCL2 antagonist of cell death, or pBAD for short, which was found to be five times more active in the pacemaker-treated group than in the untreated group.

A second protein, p38 MAP kinase, known to stimulate fibrosis and cell death, was twice as active in late-contracting parts of failing hearts in untreated dogs, than in the same heart zone of dogs who underwent pacemaker resynchronization therapy.

Other proteins that lead to heart cell death and worsen contraction were overexpressed in dogs with untreated heart failure, but not in the pacemaker-treated group. These included calcium-calmodulin-dependent kinase (CaMKII), which is linked to arrhythmia, and tumor necrosis factor-alpha (TNF), which is also tied to damaging inflammation and cell death.

The enzyme Akt, a promoter of cell survival when turned on, was markedly less active in the group whose hearts continued to beat out of sync.

Researchers next plan to look at how pacemakers stimulate biological changes in the heart, with the aim of developing treatments that bring the heart back to a normal, healthy state.

In cardiac resynchronization therapy, both major pumping chambers, known as the right and left ventricles, are stimulated at the same time with a biventricular pacemaker to optimize the muscles beat so that one side does not beat a short time before the other.

The American Heart Association estimates that more than 5 million Americans have some form of congestive heart failure, marked by symptoms such as shortness of breath and fatigue.


'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug, Pacemaker Fight Irregular Heartbeat
2. IPods Dont Interfere With Heart Pacemakers
3. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
4. Taxol bristle ball: a wrench in the works for cancer
5. Cancer control in Europe works; now it is time to extend it to poorer countries
6. SecureWorks Ranked 6th in Deloittes Technology Fast 50 Program for Georgia
7. AK Steel Reaches VEBA Health Care Settlement With Middletown Works Retirees
8. IOM workshop on less confusing drug labeling, Oct. 12
9. CIDM Collaborates With World Congress to Advance Dialog on Online Provider Networks at WHIT 3.0
10. Crittenton Hospital Medical Center to Participate in United Physicians myWorkspace(R) Initiative
11. MIT works toward novel therapeutic device
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... has awarded $10.1 million in supplemental funding to bolster ... of sex in preclinical and clinical studies. , This ... is a catalyst for considering sex as a fundamental ... in preclinical research can obscure key findings related to ... approach will result in greater awareness of the need ...
(Date:9/23/2014)... The Westlake Village sedation dentist ... oral sedation with treatment for new patients. Studies have ... dental anxiety or dental phobia. These common conditions are ... keep patients from seeking desperately needed dental care. , ... and surrounding areas now have an opportunity to manage ...
(Date:9/23/2014)... September 23, 2014 Kenall Manufacturing, ... expanded its MedMaster™ M4 product line with a ... the M4 product line – currently available with ... – providing more flexibility when designing lighting for ... MedMaster M4 Series include:, •Three sizes available ...
(Date:9/23/2014)... 23, 2014 Catalent Pharma ... delivery technologies and development solutions for drugs, ... that it had reached an exclusive development ... company, Cingulate Therapeutics (CTx), to support the ... pharmaceutical products for the treatment of Attention ...
(Date:9/23/2014)... losing your job can increase the risk for developing asthma, ... more than 7,000 employed adults in Germany. Between 2009 and ... questions about the respiratory disorder and also on whether they ... More than 100 new cases of asthma were diagnosed among ... study period. The researchers noted that for every 25 ...
Breaking Medicine News(10 mins):Health News:New supplemental awards apply sex and gender lens to NIH-funded research 2Health News:New supplemental awards apply sex and gender lens to NIH-funded research 3Health News:The Sedation Dental Office is Now Offering Complimentary Oral Sedation with Treatment for New Patients 2Health News:The Sedation Dental Office is Now Offering Complimentary Oral Sedation with Treatment for New Patients 3Health News:Kenall Expands MedMaster™ M4 Surgical Suite Product Portfolio with New 1'×4' Option 2Health News:Kenall Expands MedMaster™ M4 Surgical Suite Product Portfolio with New 1'×4' Option 3Health News:Catalent and Cingulate Therapeutics Sign Exclusive Agreement for Development of New ADHD Treatments 2Health News:Catalent and Cingulate Therapeutics Sign Exclusive Agreement for Development of New ADHD Treatments 3Health News:Job Worries Can Raise Asthma Risk, Study Says 2
... Alberta - A University of Alberta researcher in collaboration ... really does come with age, at least when it ... Dr. Florin Dolcos, assistant professor of psychiatry and neuroscience ... patterns that help healthy older people regulate and control ...
... 12 Not so long ago, any mention ... images of third-world,children with rickets and bone deformities. ... world to the developed, where Vitamin D deficiency,among ... rising to,astronomical proportions -- by some estimates, affecting ...
... Would Have Improved Benefits for Prevention, Mental,Health ... HARRISBURG, Pa., June 12 SUMMARY: ... critical legislation to protect and,improve Medicare for ... it. The,Medicare Improvements for Patients and Providers ...
... Serve Elective Cash Pay ... Patients, ... services for elective (cash pay) surgery, today,announced a leap forward in its ... bariatric surgeons, cash pay business.,Beginning July 1st, 2008, the BLISCare(SM) insurance policy ...
... complaints of insomnia predicted a healthier life, study finds ... is associated with healthy aging, a new study found. ... assessed 2,226 women aged 60 and older for use ... awakening, snoring, overall sleep quality, and sleep duration. Based ...
... MEDRAD, INC., has signed a,distribution and ... owned subsidiary of Siemens Medical Solutions USA, ... to inject Fluorodeoxyglucose,(FDG) for Positron Emission Tomography/Computed ... way. The partnership will leverage,MEDRAD,s soon to ...
Cached Medicine News:Health News:New research shows how aging brain brings a healthy dose of perspective 2Health News:Spotting Vitamin-D Deficiency in the Absence of Symptoms: ZRT Laboratory's New, One-of-a-Kind Blood Spot Test Answers the Call for Early Detection of Rapidly Rising D-Deficiencies 2Health News:AARP PENNSYLVANIA NEWS ALERT: AARP Dismayed by Senate Vote to Block Medicare Improvement Bill 2Health News:AARP PENNSYLVANIA NEWS ALERT: AARP Dismayed by Senate Vote to Block Medicare Improvement Bill 3Health News:BLIS to Offer Coverage Through 'A' Rated Insurance Carrier 2Health News:BLIS to Offer Coverage Through 'A' Rated Insurance Carrier 3Health News:Better Sleepers Are 'Successful Agers' 2Health News:MEDRAD and PETNET Solutions Partner for Innovative FDG Delivery 2Health News:MEDRAD and PETNET Solutions Partner for Innovative FDG Delivery 3
(Date:9/23/2014)... Canada , September 23, 2014 ... and lifestyle related disorders and increasing number of foreign ... demand for probiotic in India ... as one of the most high growth potential markets ... concerns among consumers especially among the youth, changing food ...
(Date:9/23/2014)... CORALVILLE, Iowa , Sept. 23, 2014 /PRNewswire/ ... in the discovery and development of proprietary new ... received a No Objection Letter (NOL) from Health ... Canada for its lead product candidate ... hydrocodone prodrug in development for acute moderate to ...
(Date:9/23/2014)... , Sept. 23, 2014  While proton therapy recently began in the ... Ashya King , another case in the United States ... a young boy who was given just days to live now looks ... Logan Green of Arizona complained of a ... of medical treatments that will conclude Sept. 23, when he completes ...
Breaking Medicine Technology:India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 2India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 3KemPharm Receives Health Canada Approval to Begin KP201 Clinical Trials in Canada 2KemPharm Receives Health Canada Approval to Begin KP201 Clinical Trials in Canada 35-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 25-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 35-Year-Old Brain Cancer Patient Completes Proton Therapy, Awaits Kindergarten 4
... The Dutch biotech company Skyline Diagnostics B.V. (Skyline) ... (Clavis) disclosed signing a research agreement. Under this agreement, ... individual Acute Myeloid Leukemia (AML) patients that may benefit ... This drug, elacytarabine, is a novel elaidic acid derivative ...
... demonstrate its continued commitment to innovative immunoglobulin (Ig) research, ... is seeking proposals for the next round of Interlaken ... program provides monetary grants and/or product supply to advance medical ... in the treatment of neurological disorders. From the ...
Cached Medicine Technology:Skyline Diagnostics and Clavis Pharma to Collaborate on Patient Selection Biomarker Discovery for Leukemia Drug elacytarabine 2CSL Behring Seeks Proposals for Interlaken Leadership Awards, Supporting Innovative Research Into Neuroimmunology 2CSL Behring Seeks Proposals for Interlaken Leadership Awards, Supporting Innovative Research Into Neuroimmunology 3
The Storz Premiere comes as anterior, posterior and anterior/posterior combo. The combo provides the following modes irrigation, irrigation/aspiration, vitrectomy, and illumination....
CataRhex PRO the portable cataract extraction system with automated capsulotomy....
Phacoemulsification system is a complete anterior segment surgical instrument. Its simplified design and unique innovations provide optimal surgical performance....
Aaron Burr II with disposable 1mm burr for corneal rust ring removal and a diamond burr tip for polishing the pterygium bed after surgical removal and for lid margin lesions....
Medicine Products: