Navigation Links
Pacemaker tune-up works chemical wonders on damaged hearts in dogs
Date:3/5/2008

ing them return to daily activities. But these benefits do not directly fix the cause for the delayed conduction; they merely circumvent it.

Now that we have found that resynchronization is doing more fundamental things to the heart muscle, we should be able to better combine these devices with drugs to maximize long-term survival and outcomes, says Kass.

Chakir says previous research has shown that a year after implantation, pacemaker resynchronization has been effective at reducing mortality in some heart failure patients by as much as 36 percent, but researchers have not until now really understood the biological effect of the devices beyond the physical mechanics of contraction.

In the current study, the Hopkins team determined the biological effects of pacemaker treatment on the hearts of 22 dogs with heart failure induced by making the heart beat faster. A key nervelike, electrical pathway that normally assures the muscles harmonious beat was also damaged, producing a wobbly, discoordinated contraction. The asymmetric heart-failure condition was allowed to take its natural progressive course in half the dogs; the others had cardiac resynchronization therapy with implantation of a pacemaker.

Results from tissue analysis in these two groups of dogs were then compared to a third group of six dogs with healthy hearts.

In the heart failure groups, the scientists report major ups and downs in production or activity levels in 17 out of more than two dozen proteins known to be involved with heart cell stress, survival and death.

The alterations were especially notable in the group that did not have their hearts retuned. But tissue levels and activity of these proteins were restored toward normal in those with pacemakers that were tuned to reestablish an even, coordinated contraction, with both sides beating at the same time.

Among the stand-out proteins was one that prevents heart muscle ce
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug, Pacemaker Fight Irregular Heartbeat
2. IPods Dont Interfere With Heart Pacemakers
3. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
4. Taxol bristle ball: a wrench in the works for cancer
5. Cancer control in Europe works; now it is time to extend it to poorer countries
6. SecureWorks Ranked 6th in Deloittes Technology Fast 50 Program for Georgia
7. AK Steel Reaches VEBA Health Care Settlement With Middletown Works Retirees
8. IOM workshop on less confusing drug labeling, Oct. 12
9. CIDM Collaborates With World Congress to Advance Dialog on Online Provider Networks at WHIT 3.0
10. Crittenton Hospital Medical Center to Participate in United Physicians myWorkspace(R) Initiative
11. MIT works toward novel therapeutic device
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014 For electronic publishing expert eBooks2go, ... down to a miraculous connection and precision timing. This ... while, but over the past three decades, Ms. Wixom ... was finding it rather tedious to expand her readership ... A phone call, an anniversary, and a second-place trophy ...
(Date:9/17/2014)... Wa (PRWEB) September 17, 2014 Diabetes ... by the Telegraph in August 2014, scientists made ... for diabetes, but still failed. The article indicates that ... Despite this existing fact, there are many forward-thinking entrepreneurs ... diabetes treatment in a natural way. Dr. Kenneth Pullman ...
(Date:9/17/2014)... ICS Learning Group, Inc. won a coveted ... for the Best Use of Games and Simulations for ... operational safety training module that ICS developed for one ... an approach that combined realistic 3D simulation with gamification, ... to a video game, including competition among trainees, to ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Health.Verticalize, a ... people explore their health insurance options in the 2014 ... Network. , Moving forward Health Network ... website. The company has intentionally remained out of the ... network from a single website to its present position ...
(Date:9/16/2014)... Recently, BamboofloorChina.com, the popular online supplier ... of strand woven bamboo floors to its ... big promotion for the new items; the current discount ... is a great shopping season. Therefore, BamboofloorChina.com spares no ... new customers. All practical items offered by BamboofloorChina.com are ...
Breaking Medicine News(10 mins):Health News:Versatile Author Wixom Forges Lasting Relationship with Digital Virtuoso eBooks2go 2Health News:Versatile Author Wixom Forges Lasting Relationship with Digital Virtuoso eBooks2go 3Health News:Versatile Author Wixom Forges Lasting Relationship with Digital Virtuoso eBooks2go 4Health News:Discover a Safe and Effective Treatment for Diabetes with The Diabetes Protocol – Vinamy 2Health News:ICS Learning Group Wins Gold in the 2014 Brandon Hall Excellence Competition for Best Use of Games and Simulations for Learning 2Health News:Health.Verticalize Rebrands as Health Network After Growing to 15 Million Users in Less Than One Year 2Health News:Health.Verticalize Rebrands as Health Network After Growing to 15 Million Users in Less Than One Year 3Health News:BamboofloorChina.com Announces Its Promotion For Strand Woven Bamboo Floors 2
... , EMERYVILLE, Calif., Sept. 21 Bionovo, Inc. (Nasdaq: ... the company received a letter from NASDAQ stating that, for the ... stock has closed below the minimum $1.00 per share requirement for ... that the company has been provided a period of 180 calendar ...
... , , , ... Medical, Inc. has made a $15 million equity investment in the company. ... officer of Micell, said, "We are excited to have a company of ... forward to collaborating with them to expand the use of our coating ...
... , , BELMONT, Calif., ... focused on improving the lives of patients with sleep-disordered breathing, ... the Runners-Up Award in The Wall Street Journal ... were published in the September 14, 2009 edition of ...
... results seen with both open surgery and minimally invasive ... -- Successful repair of nasal fractures is possible using ... long as the procedure is appropriate for the type ... be selected by taking into account factors such as ...
... American Gastroenterological Association (AGA) Foundation for Digestive Health and ... businessman and photographer, Bernard Lee Schwartz, has honored his ... for pancreatic cancer research. The $225,000 gift from the ... with funding and protected time for three years to ...
... A multicenter study in Asia found drug-eluting stents ... patients with chronic total occlusions (CTOs) undergoing PCI. Results ... annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by ... the study, "Drug-Eluting Stents for the Treatment of Chronic ...
Cached Medicine News:Health News:Bionovo Notified by NASDAQ of Minimum Bid Price Deficiency 2Health News:Bionovo Notified by NASDAQ of Minimum Bid Price Deficiency 3Health News:Ventus Medical Announces PROVENT(R) Sleep Apnea Therapy Recognized by The Wall Street Journal 2009 Technology Innovation Awards 2Health News:Ventus Medical Announces PROVENT(R) Sleep Apnea Therapy Recognized by The Wall Street Journal 2009 Technology Innovation Awards 3Health News:Best Option for Fractured Nose Varies by Patient 2Health News:California family honors father with second AGA Foundation Research Scholar Award 2Health News:Drug-eluting stents safe, effective for treatment of chronic total occlusions 2
(Date:9/16/2014)... -- Chairman and CEO Bernard J. Tyson announced ... the role of interim chief information officer (CIO) for ... "Kaiser Permanente is a recognized leader ... high-quality care and service we provide to our 9.5 ... extensive experience in information technology. I am confident that ...
(Date:9/16/2014)... Kan. , Sept. 16, 2014  Aratana ... pet therapeutics company focused on licensing, developing and ... announced that it is commencing an underwritten registered ... All of the shares are being offered by ... Barclays are acting as joint book-running managers for ...
(Date:9/16/2014)... Sept. 16, 2014 Adaptive Biotechnologies, a clinical ... to profile the adaptive immune system, is pleased to ... Chief Commercial Officer (CCO). The addition of Brain to ... hires from leading global healthcare companies, including Dean ... Counsel) from Genomic Health and Sean Nolan ...
Breaking Medicine Technology:Kaiser Foundation Health Plan, Inc. and Kaiser Foundation Hospitals Name Interim Chief Information Officer 2Aratana Therapeutics, Inc. Announces Proposed Public Offering 2Veteran Genoptix and Gen-Probe Executive, Brian Hansen, joins Adaptive Biotechnologies as Chief Commercial Officer 2Veteran Genoptix and Gen-Probe Executive, Brian Hansen, joins Adaptive Biotechnologies as Chief Commercial Officer 3
... , INDIANAPOLIS, Dec. 7 Roche Diagnostics ... center in Pleasanton, California, as part of an initiative to ... and independent laboratories on the west and east coasts. Roche ... and is planning to open an additional facility in New ...
... , SILVER SPRING, Md., Dec. 7 ... of excess radiation during CT perfusion imaging of the ... imaging facilities and practitioners with interim recommendations to help ... issued an initial safety notification in October after learning ...
Cached Medicine Technology:Roche Diagnostics Opens State-of-the-Art Training Center in California 2FDA Makes Interim Recommendations to Address Concern of Excess Radiation Exposure during CT Perfusion Imaging 2FDA Makes Interim Recommendations to Address Concern of Excess Radiation Exposure during CT Perfusion Imaging 3
... thin collagen coated highly compliant ... thin wall construction offers optimal ... Hemacarotid UltraThin Patch provides superb ... and healing, without suture hole ...
The VasoSeal Low Profile device is designed for smaller sheath angiography procedures. VasoSeal Low Profile. Seal your arterial punctures with confidence....
D-Stat Radial is a dry version of the D-Stat together with a compression band, and is designed for the control of surface bleeding from vascular access sites, including the sites on the radial artery...
... engineered to close arteriotomies with ease ... with a simple trigger actvated mechanism, ... deliver sheath gently locks onto the ... the site before, during, and after ...
Medicine Products: