Navigation Links
Pacemaker tune-up works chemical wonders on damaged hearts in dogs
Date:3/5/2008

ing them return to daily activities. But these benefits do not directly fix the cause for the delayed conduction; they merely circumvent it.

Now that we have found that resynchronization is doing more fundamental things to the heart muscle, we should be able to better combine these devices with drugs to maximize long-term survival and outcomes, says Kass.

Chakir says previous research has shown that a year after implantation, pacemaker resynchronization has been effective at reducing mortality in some heart failure patients by as much as 36 percent, but researchers have not until now really understood the biological effect of the devices beyond the physical mechanics of contraction.

In the current study, the Hopkins team determined the biological effects of pacemaker treatment on the hearts of 22 dogs with heart failure induced by making the heart beat faster. A key nervelike, electrical pathway that normally assures the muscles harmonious beat was also damaged, producing a wobbly, discoordinated contraction. The asymmetric heart-failure condition was allowed to take its natural progressive course in half the dogs; the others had cardiac resynchronization therapy with implantation of a pacemaker.

Results from tissue analysis in these two groups of dogs were then compared to a third group of six dogs with healthy hearts.

In the heart failure groups, the scientists report major ups and downs in production or activity levels in 17 out of more than two dozen proteins known to be involved with heart cell stress, survival and death.

The alterations were especially notable in the group that did not have their hearts retuned. But tissue levels and activity of these proteins were restored toward normal in those with pacemakers that were tuned to reestablish an even, coordinated contraction, with both sides beating at the same time.

Among the stand-out proteins was one that prevents heart muscle ce
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug, Pacemaker Fight Irregular Heartbeat
2. IPods Dont Interfere With Heart Pacemakers
3. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
4. Taxol bristle ball: a wrench in the works for cancer
5. Cancer control in Europe works; now it is time to extend it to poorer countries
6. SecureWorks Ranked 6th in Deloittes Technology Fast 50 Program for Georgia
7. AK Steel Reaches VEBA Health Care Settlement With Middletown Works Retirees
8. IOM workshop on less confusing drug labeling, Oct. 12
9. CIDM Collaborates With World Congress to Advance Dialog on Online Provider Networks at WHIT 3.0
10. Crittenton Hospital Medical Center to Participate in United Physicians myWorkspace(R) Initiative
11. MIT works toward novel therapeutic device
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... This Method to get a ... for practitioners. , The Hypopresive (aka Hipopressive) ... and Movement specializing in physical rehabilitation. Dr. Marcel ... reeducation that traditional abdominal exercises after pregnancy increased ... etc. , The Hipopressives exercises pull back in ...
(Date:10/31/2014)... 31, 2014 (HealthDay News) -- Surgery for low back ... in the United States you live, a new report ... low back pain at some point in their lives, ... medical care for a spine problem," co-author Brook Martin, ... Practice, said in a college news release. In ...
(Date:10/31/2014)... say that either they or a family member have ... latest issue of The Gerontological Society of America,s ... which goes on to show that Americans strongly support ... end-of-life health care wishes. , This PP&AR , ... features 12 articles that present new ways of understanding ...
(Date:10/31/2014)... 2014 Urban Hydroponics, Inc. (OTCQB:URHY), a ... it has signed a Binding Letter of Intent (LOI) ... cultivation sector - Urban Cultivator Inc. (“Urban Cultivator”), BC ... Metal Inc. (“W3 Metal” and together with Urban Cultivator ... to the LOI and an earlier non-binding term sheet, ...
(Date:10/31/2014)... October 31, 2014 Triple Board Certified ... hair restoration services to transform the appearance of military ... American Academy of Facial Plastic and Reconstruction Surgery (AAFPRS) ... to restore the facial hair Jones lost during an ... The pro-bono hair restoration procedure, valued around $16,000, took ...
Breaking Medicine News(10 mins):Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:Spinal Surgery Varies by Region in U.S.: Study 2Health News:Advance directives can benefit patients, families, and health care system 2Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 2Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 3Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 4Health News:Urban Hydroponics Inc. Signs Definitive Agreement to Merge with Canadian Hydroponics Companies 5Health News:Miami Hair Restoration Specialist Transforms Wounded Soldier 2
... ... tracking, performance analysis, sales and management training, announced that its non-profit organization, PrideAmerica is ... Super Bowl Hearing Mission on Wednesday, February 3rd, from noon – 4 pm at ... ...
... NASHVILLE, Tenn. , Jan. 29 HCA ... quarter and fiscal year ended December 31, 2009 . ... Company,s year-end financial and accounting procedures. , (Logo: ... these uncertain economic times," said Richard M. Bracken , ...
... , DETROIT , Jan. 29 ... M.D., Ph.D., has been named the new president and chief ... thoracic oncologist, Dr. Bepler will begin his new position ... , In addition to his chief administrative duties, Dr. ...
... , CHICAGO , Jan. 29 ... decision, four national organizations representing dentists, physicians and veterinarians ... exclude health professionals from controversial new regulation intended to ... A letter sent to FTC Chairman Jon Leibowitz ...
... facial recognition systems, study authors suggest , FRIDAY, Jan. 29 ... as long as they think the faces are odd-shaped flowers, ... researchers from Australia and France determined that bees could be ... a sweet treat for doing so. , However, this doesn,t ...
... counterfeit Viagra, study says , FRIDAY, Jan. 29 (HealthDay ... especially drugs purporting to treat erectile dysfunction, are playing Russian ... best the drugs won,t help you and at worst they ... be wasting your money or you may actually be hurting ...
Cached Medicine News:Health News:CallSource joins Starkey Hearing Foundation to Tackle Children's Hearing Loss in Super Bowl Mission 2Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 2Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 3Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 4Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 5Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 6Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 7Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 8Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 2Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 3Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 4Health News:Health Professionals Petition FTC For Relief From Red Flags Rule 2Health News:Health Professionals Petition FTC For Relief From Red Flags Rule 3Health News:Fake Drugs Bought on the Web Pose Big Health Risks 2Health News:Fake Drugs Bought on the Web Pose Big Health Risks 3
(Date:10/31/2014)... BARCELONA , October 31, 2014 ... to infringe two Australian patents of B. Braun Melsungen AG ... Australia safety IV catheters manufactured by Poly ... of Australia proceeding number VID 463 ... In the detailed judgment, Multigate was found to ...
(Date:10/31/2014)... , October 30, 2014 ... announced the addition of the  "Process Validation in ... their offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... and Risk Based Approach to Process Validation for ... Management FDA Process Validation Guidance ...
(Date:10/31/2014)... , Oct. 31, 2014 Though therapies ... technologies are expected to show an annual increase of ... value of nearly $1 billion, according to Kalorama Information,s ... from proprietary stem cell therapeutics that have gained or ... "As drug developers tackle ever more complicated ...
Breaking Medicine Technology:B. Braun Wins Patent Disputes Against Poly Medicure Ltd's Australian Distributor Multigate Medical Devices Pty. Ltd. and Spanish Distributor Dextromédica S. L. 2Process Validation in the US and EU (Workshop, London) 2Process Validation in the US and EU (Workshop, London) 3Process Validation in the US and EU (Workshop, London) 4Report: Stem Cell Technologies Market Growing 2
... May 11, 2012  Amgen (NASDAQ: AMGN ) ... vice president of Research and Development at Amgen will ... Administration (FDA) stakeholder hearing on biosimilars. Miletich will urge members ... for biosimilars to establish approval standards that advance patient ...
... Mylan Inc. (Nasdaq: MYL ) today ... mg, 20 mg, 40 mg and 80 mg in ... has received marketing authorization from each country,s respective health ... is the generic version of Pfizer,s Lipitor® Tablets. This ...
Cached Medicine Technology:Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 2Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 3Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 4Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 5Amgen To Provide Testimony At FDA Stakeholder Hearing On Biosimilars 6Mylan Launches Generic Lipitor® in Five European Countries 2
... Laparoscopic Instruments incorporate a layered design unique ... and monitored to prevent stray electrosurgical burns ... by insulation failure or capacitive coupling; a ... built into all AEM Instruments provides a ...
... Instruments incorporate a layered design unique in ... monitored to prevent stray electrosurgical burns along ... insulation failure or capacitive coupling; a well-documented ... into all AEM Instruments provides a neutral ...
... 5mm AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
... 5mm AEM Laparoscopic Instruments incorporate a layered ... are shielded and monitored to prevent stray ... instrument caused by insulation failure or capacitive ... protective shield built into all AEM Instruments ...
Medicine Products: