Navigation Links
PXR: A stepping stone from environmental chemical to cancer?
Date:7/11/2011

Several chemicals that can accumulate to high levels in our body (for example BPA and some pesticides) have been recently linked to an increased risk of cancer and/or impaired responsiveness to anticancer drugs. A team of researchers, led by Sridhar Mani, at Albert Einstein College of Medicine, New York, has now identified a potential mechanistic link between environmental exposure to these foreign chemicals (xenogens) and cancer drug therapy response and survival.

PXR is one protein by which cells (including tumor cells) can sense xenogens. In their study, Mani and colleagues determined that activation of PXR was sufficient to enhance the cancerous characteristics of human colon tumor cell lines and primary human colon cancer tissue xenografted into immune systemdeficient mice. Further analysis indicated FXR activation leads to colon cancer growth through the induction of the growth factor FGF19. The authors therefore suggest that it will be important to investigate further the extent to which the environment might play a role in tumor recurrence through PXR activation.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. Step Up to Speak Up Events Use Spoken Word and African-American Greek Tradition of Stepping to Raise Awareness for Organ and Tissue Donation
2. Are Advanced Practitioners Stepping on the Practice Turf of Physicians?
3. PHNS Implements New Accelerated Claims Resolution Services With iSoftStone
4. Gladstones Robert Mahley to receive Research!America advocacy award
5. Major milestone achieved by our joint venture in China
6. Bioniche Achieves Two Additional Milestones Under Licensing Agreement; Endo Takes up Global Rights
7. Obesity -- mild or severe -- raises kidney stone risk
8. Greystone Healthcare Chooses Patient Placement Systems to Automate Admissions Processes
9. Top-Rated Medicare Advantage Plan Reaches 27,000-Member Milestone
10. Antidepressants in Pregnancy May Delay Developmental Milestones
11. Charlie Kimball Secures Partnership with Novo Nordisk, Maker of the Levemir FlexPen, for 2010 Firestone Indy Lights Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... ... Medicine recently spoke at a popular international aesthetics conference for medical professionals about ... restoring his patients’ health and his growing practice. , Dr. George K. ...
(Date:8/22/2017)... TX (PRWEB) , ... August 22, 2017 , ... Five Star Glass is new to ... provide repair and replacement of auto glass for most makes and models, in Grand Prairie, ... the USA. , They have been a family owned business for the past 40 ...
(Date:8/22/2017)... ... ... “Glimpses Of Light”: is a unique and thought inspiring guide toward self-discovery ... published author, J.M. Shepherd, a writer, teacher, traveler, and metaphysician, the author has spent ... shares, “Love is one of the least understood and yet most sought-after pleasures known ...
(Date:8/21/2017)... ... August 22, 2017 , ... PracticeMatch, a company that ... healthcare employers connect with physicians and advanced practitioners like nurse practitioners and ... in August through November of this year. The online career fairs will allow ...
(Date:8/21/2017)... , ... August 21, 2017 , ... ... announced that it has become the Official Technology Partner of North Country Region ... (Advanced Event Systems) volleyball software, along with providing sport management software to ...
Breaking Medicine News(10 mins):
(Date:8/14/2017)... and PETACH TIKVAH, Israel ... (NASDAQ: BCLI), a leading developer of adult stem cell ... second quarter ending June 30, 2017. ... of preparing for our pivotal Phase 3 trial to ... Lebovits , President and Chief Executive Officer of BrainStorm. ...
(Date:8/8/2017)... Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), a ... reports its financial results for the second quarter ended ... the second quarter 2017 and to date: ... development programs for the Company,s lead project, BL-8040: ... study with BL-8040 as novel stem cell mobilization treatment ...
(Date:8/7/2017)... WARSAW, Ind. , Aug. 7, 2017 Zimmer ... in musculoskeletal healthcare, today announced that its Board of Directors ... stockholders for the third quarter of 2017. ... will be paid on or about October 27, 2017 to ... September 22, 2017.  Future declarations of dividends are subject to ...
Breaking Medicine Technology: