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PTC Therapeutics Announces Additional $1.6 Million Grant from the Spinal Muscular Atrophy Foundation
Date:12/6/2007

Expanded Collaboration Focuses on Discovery of Small-Molecule Drugs for

Spinal Muscular Atrophy

SOUTH PLAINFIELD, N.J., Dec. 6 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC), a biopharmaceutical company focused on the discovery, development, and commercialization of small-molecule drugs targeting post-transcriptional control mechanisms, today announced an expanded research collaboration with the Spinal Muscular Atrophy (SMA) Foundation. The collaboration builds on the existing research agreement to identify and characterize compounds that have the potential to treat SMA by increasing production of the survival motor neuron (SMN) protein, the absence of which causes SMA. Under the terms of the expanded agreement, the SMA Foundation will provide an additional $1.6 million in funding to PTC based upon completion of certain milestones.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010919/PTCLOGO )

"We are pleased to expand this collaboration with the SMA Foundation," stated Stuart W. Peltz, Ph.D., President and Chief Executive Officer of PTC Therapeutics. "By applying our proprietary technologies, we have made important progress in our efforts to identify treatments for SMA. This program is another example of the breadth of our approach and we look forward to our continued collaboration with the SMA Foundation as we seek to develop treatments for disorders with high unmet medical need."

"PTC has been an ideal partner in the identification of molecules targeting SMN," noted Meg Winberg, Director of Discovery Research for the SMA Foundation. "We have been impressed with their progress and are pleased to continue our work together to identify and advance potential treatments for SMA."

About Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a genetic, motor neuron disease characterized by the wasting of skeletal musc
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SOURCE PTC Therapeutics, Inc.
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