Navigation Links
PSA test better predicts cancer in men taking prostate-shrinking drug
Date:12/16/2010

0.5 mg dose of dutasteride. The men had elevated PSA levels (2.5 ng/ml-10 ng/ml) but no evidence of cancer on biopsies performed within six months of enrolling in the trial.

Results published earlier this year in the New England Journal of Medicine showed that dutasteride reduced the risk of a prostate cancer diagnosis by 23 percent. Dutasteride appears to keep tumors small or shrink them to the point that they are less likely to be detected by a biopsy, says Andriole, who led the steering committee that oversaw the earlier trial.

In the current analysis, the researchers looked at the performance of PSA as a marker for prostate cancer, particularly for aggressive cancer. Among men taking dutasteride, the investigators found that any subsequent rise in PSA levels over the course of the study was more likely to be linked to aggressive, high-grade tumors (Gleason score 7-10), compared to rising PSA levels in men on a placebo.

The Gleason scoring system measures tumor aggressiveness based on biopsy results and can range from 2-10, with 10 being the most aggressive.

"If a man is taking dutastride and his PSA level starts to rise, he has a higher chance of having an aggressive cancer," Andriole says. "This makes PSA a more effective screening tool for prostate cancer but even more importantly for aggressive cancer."

Over four years, PSA levels increased in 72 percent of men taking a placebo and only 29 percent of men taking dutasteride, the data show. However, there was no significant difference in high-grade tumors between the two groups.

Men taking dutasteride were almost twice as likely to have aggressive prostate cancer if their PSA levels rose, compared to men whose PSA levels went up while taking a placebo. In men with any increase in PSA, aggressive, high-grade tumors were diagnosed in 13.2 percent of those on dutasteride and 7.7 percent of those taking a placebo.

Even a slight rise in PSA levels was a
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New survey device gets better information on teenage sexual behavior
2. Buprenorphine is better than methadone for opioid dependence in pregnant women, study shows
3. UTHealth study suggests private insurers control health care spending better than Medicare
4. Good grades in high school lead to better health, study finds
5. Cognitively-impaired human research subjects need better protection
6. Contaminated Butter Points to Need for Better Surveillance, Study Says
7. Littlest Kids in Big Day-Care Centers May Have Better Health Later On
8. Better imaging from bench to bedside
9. Active surveillance for low-risk prostate cancer may offer better quality-of-life
10. Better Outcomes Seen With Early Rheumatoid Arthritis Diagnosis
11. Screening tool may better identify heart disease in African-Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Dr. Andrew Campbell, one of the ... expansion of Quintessa Aesthetic Center into a third location ... W307 N1497 Golf Road in Suite 200 and will ... the new Delafield location will offer a variety of ... Botox, filler injectables , micro laser peels, chemical ...
(Date:11/28/2014)... Miami's Plastic Surgery of the Face recently introduced ... Jeffrey Epstein is excited to offer patients the ... the site is uniquely designed for easing viewing on ... of all prospective rhinoplasty patients research upcoming procedures online. ... with smartphones, tablets, and laptops, as well as the ...
(Date:11/28/2014)... The Alternative Health Therapies ... five years. The industry has been buoyed by ... either alternative to conventional Western medicine or complementary ... David Whytcross, “industry revenue has been further boosted ... insurance membership.” Meanwhile, improving economic conditions following the ...
(Date:11/28/2014)... Written and narrated by award winning author ... the “The Happiest Man In the World: Life Lessons ... how and why Project C.U.R.E. came to be. , Raised ... and the Reverend Richard W. Jackson, Dr. Jackson exceeded his ... but realized that he wasn’t happy. Prompted by this realization, ...
(Date:11/28/2014)... (HealthDay News) -- Planning on seconds at Thanksgiving Day ... clinically known as gastroesophageal reflux disease (GERD) -- a few ... an ear, nose and throat specialist at Lenox Hill Hospital ... manage GERD on Thanksgiving: Pace yourself. ... small meals throughout the day. It,s also a good idea ...
Breaking Medicine News(10 mins):Health News:Dr. Andrew Campbell to Expand Quintessa Aesthetic Center into Delafield 2Health News:Top Rhinoplasty Surgeon Launches Innovative Website 2Health News:Alternative Health Therapies in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Alternative Health Therapies in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Alternative Health Therapies in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Thanksgiving Weekend Audiobook Treat! “The Happiest Man In the World: Life Lessons From a Cultural Economist” by Dr. James W. Jackson 2Health News:Don't Let Chronic Heartburn Spoil Your Thanksgiving Feast 2
... watched such fare more likely to act out at 7, ... Preschool boys exposed to violent television -- even cartoons -- ... warn. , Their findings don,t definitively prove that TV makes ... fare, according to the researchers. But the link does appear ...
... Fla. -- If you go to the hospital within one ... heart attack, your chances of getting proper treatment are nearly ... hours before seeking treatment, according to results presented today at ... , This research should emphasize to patients that getting help ...
... WASHINGTON, Nov. 5 For the next two ... will be in wildfire-ravaged,areas of Southern California, attempting ... they need. The first stop will,be from 10 ... Catholic Community Church,in Fallbrook, CA., This marks ...
... Inc., the leading,provider of Web-based employee performance and ... 2007 was the organization,s strongest,to date. The organization ... percent year-over-year revenue growth over the third quarter ... high priority for our,organization and this new solution ...
... a cancer-prevention gene in the response to drug treatment for ... also known as the guardian of the genome, is known ... the gene are associated with a high incidence of cancer ... to tumours. , In childhood cancers such as neuroblastoma, p53 ...
... temperatures may help keep vessels constricted, experts say , , MONDAY, ... has a chill factor: Hypertension is harder to control in ... to be presented Monday at the American Heart Association annual ... has been noted for decades that people,s blood pressure tends ...
Cached Medicine News:Health News:TV Violence May Spur Aggression in Boys 2Health News:TV Violence May Spur Aggression in Boys 3Health News:Mayo Clinic identifies new risk factor for heart attack patients 2Health News:'Help is Here Express' Bus Tour in California to Help Fire Victims Access Prescription Medicines 2Health News:'Help is Here Express' Bus Tour in California to Help Fire Victims Access Prescription Medicines 3Health News:Halogen Software Achieves Most Successful Quarter in Company History - Includes Record Year-Over-Year Overall and License Revenue 2Health News:Halogen Software Achieves Most Successful Quarter in Company History - Includes Record Year-Over-Year Overall and License Revenue 3Health News:Blood Pressure Tougher to Tame in Winter 2
(Date:11/28/2014)... , Nov. 28, 2014 Chinese magnesium alloy ... that its biodegradable magnesium alloy bone fixation screw has ... medical apparatus and instrument and that the company ... an interview with Science and Technology Daily ... the company chairman and founder, Professor Li Yangde ...
(Date:11/26/2014)... , Nov. 26, 2014  Thoratec Corporation (NASDAQ: ... mechanical circulatory support therapies to save, support and restore ... two upcoming investor conferences. On Tuesday, December ... Annual Piper Jaffray Healthcare Conference.  D. Keith ... an update on the company beginning at 11:30 a.m., ...
(Date:11/26/2014)... Calif. , Nov. 26, 2014  Genomic Health, ... Kim Popovits , Chairman, Chief Executive Officer and President, ... Jaffray Healthcare Conference at The New York Palace Hotel ... December 3 at 11:30 am Eastern Time (ET). ... of the conference call, go to the  Investor Relations ...
Breaking Medicine Technology:Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 2Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 3Chinese magnesium alloy manufacturer Eontec expects to have its medical magnesium alloy available for clinical trial in 2015 4Thoratec Announces Presentations At Investor Conferences For December 2014 2Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 2Genomic Health to Present at the 26th Annual Piper Jaffray Healthcare Conference 3
... (OTC Bulletin Board: CGNH ) announced today that ... 2 Class B common stockholders a "Stockholder Questionnaire," which the ... count of the Company,s shares currently held in "street ... If you have not received the Stockholder Questionnaires via ...
... VILLAGE, Nev., March 8, 2011 PDL BioPharma, Inc. (PDL) (Nasdaq: ... rate for its 2.00% Convertible Senior Notes due February 15, 2012 ... 15, 2015 (the 2015 Notes) effective March 7, 2011, in connection ... to all stockholders who own shares of PDL on March 8, ...
Cached Medicine Technology:CardioGenics Requests Stockholders to Participate in Stockholder Questionnaires 2PDL BioPharma Announces Conversion Rate Adjustments for 2.00% Convertible Senior Notes Due February 15, 2012 and 2.875% Convertible Senior Notes Due February 15, 2015 2
... offers improved ergonomics for today's exacting ... grippy finger rest and the large ... efficiency. Finnpipette Digitals also feature soft-touch ... (pat. pend.) and super blow-out for ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features: Eppendorf "pipette/tip" ...
This adjustable-volume digital micropipet is used to accurately measure and transfer small solution volumes in the 100-1,000 microliter range....
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (Z71,409-7) or contact custom...
Medicine Products: