Navigation Links
PSA screening to detect prostate cancer can be beneficial to younger and at-risk men
Date:5/7/2012

Screening younger men and men at risk of prostate cancer can be beneficial in reducing metastatic cancer and deaths and should not be abandoned, states an article published in CMAJ (Canadian Medical Association Journal).

The United States Preventive Services Task Force, which last issued prostate screening guidelines in 2008, recently issued a draft recommendation against prostate-specific antigen (PSA) screening for men of all ages. However, the American Cancer Society and the American Urological Association both recommend that men be given a choice about whether they should be screened. The United Kingdom and Australia take the approach of informed choice to enable patients to make their own decisions. The Canadian Task Force on Preventive Health Care, which recommended against PSA screening in its last guidelines in 1994, is expected to issue updated recommendations in 2013.

Recent research from a large, high-quality randomized trial of 162 243 men in Europe aged 55 to 69 years indicates that screening reduces deaths caused by prostate cancer. Other trials, such as the US Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, showed no benefit in screening.

"Cancer-specific mortality, not overall mortality, is the primary outcome in screening trials," writes Dr. Monique Roobol, Department of Urology, Erasmus University Medical Centre, Rotterdam, the Netherlands, with coauthors. "Because deaths from prostate cancer are a small proportion of all deaths, comparisons of overall mortality are underpowered. Thus, a screening program that reduces cancer-specific mortality should not be stopped because of a lack of reduction in overall mortality."

Screening can also reduce the incidence of metastatic cancer, as the European Randomized Study of Screening for Prostate Cancer underscores, which found a 41% reduction in metastatic disease at diagnosis of the cancer with screening.

The authors write that the decision to screen or not to screen should be individual as screening is not appropriate for every man. For elderly men with several medical issues, screening may be more harmful than beneficial, but for younger, healthy men, screening can reduce death from prostate cancer. Healthy younger men also are at lower risk of complications from biopsies and treatments compared with older men.

"Rather than abandoning a screening test that reduces death and suffering, efforts should be focused on selecting patients more carefully," conclude the authors. "Screening should be encouraged for healthy younger men and men with risk factors (e.g., black ancestry, positive family history) and discontinued for elderly men with multiple comorbidities and limited life expectancy."


'/>"/>

Contact: Kim Barnhardt
kim.barnhardt@cmaj.ca
613-520-7116 x2224
Canadian Medical Association Journal
Source:Eurekalert

Related medicine news :

1. Diabetic retinopathy research could reduce screening costs
2. Doctors Urge Routine Skin Screenings
3. Screening for Other Health Problems May Aid COPD Survival
4. Study says screening accounts for much of black/white disparity in colorectal cancer
5. No family history not a good reason for women 40-49 to stop yearly screening mammograms
6. Research examines when benefits of screening mammography outweigh the harms for women in their 40s
7. Risk factors may inform breast cancer screening
8. Routine Kidney Disease Screening Not Worthwhile, Experts Say
9. Additional blood pressure screening may reduce incidence of CVD events and death by up to 3 percent
10. Screening programs detect cases of undiagnosed rheumatic heart disease in low-resource countries
11. Role of Screening, Monitoring in Early Kidney Disease Unclear
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope For ... their lives in military battle for the country. The nonprofit Hope For Heroes ... more programs that empower independence for disabled military veterans, as well as police, firemen, ...
(Date:5/26/2016)... ... 2016 , ... Cardiac arrhythmia is a common complication following ... survival, reports a team of UPMC researchers in the largest study of its ... Thoracic and Cardiovascular Surgery, provide critical information that will hopefully lead to better ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line ... in Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than ... by government agencies, including NASA. , In 2012, NASA strategically set up 17 ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James ... Fighting Blindness, Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the ... founder of Retina Group of New York , is a Board Certified ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... In an effort to provide hair restoration ... to both Snapchat users and those who do not use the app. Dr. Mohebi, the ... new page, Dr. Mohebi Live . , Dr. Mohebi says, “The positive response ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 Amarantus BioScience ... on developing products for Regenerative Medicine, Neurology and Orphan Diseases, today ... be presenting at two upcoming investor conferences: SeeThru ... Third Avenue, New York City , NY ... Marcum MicroCap Conference   Where: Grand Hyatt ...
(Date:5/26/2016)... May 26, 2016 According to a ... Management Market - U.S. Industry Analysis, Size, Share, Growth, Trends, ... in the U.S. was valued at US$ 5.89 Bn in ... 3.4% from 2015 to 2023 to reach US$ 7.99 Bn ... current and emerging needle free drug delivery devices and the ...
(Date:5/26/2016)... -- TARE (Transarterial Radio-embolization) Using Yttrium-90 ... Overall Decreased Use of Hospital Resource ... healthcare company, has today announced the publication of ... ISPOR (International Society for Pharmacoeconomics and Outcomes Research), ... yttrium-90 glass microspheres is associated with cost savings ...
Breaking Medicine Technology: