A third study looked at how fast PSA levels rose via a measurement known as prostate-specific antigen velocity (PSAV). It found that adding PSAV to standard screening may improve the accuracy of traditional PSA screening.
The problem was that there were a lot of false-positives, said the authors, from the Feinberg School of Medicine at Northwestern University in Chicago.
The final study, from European and American researchers, also looked at PSAV, concluding that this marker may be able to pinpoint more aggressive tumors.
Again, when added to the PSA test, it may give more accurate insight into what the PSA test actually means.
"We're not making any claims right now, but this may give us clues about [how to modify] practice," said study author Thomas Neville, chief scientist and founder of Soar Biodynamics, in Los Altos, Calif.
According to news conference moderator Dr. Christopher Amling, chief of urology at Oregon Health & Science University in Portland, the AUA modified its prostate cancer screening guidelines in 2009 to recommend that men should start screening at age 40, or age 45 at the latest.
The U.S. National Cancer Institute has more on PSA screening.
SOURCES: May 16, 2011, news conference with: Christopher Amling, M.D., chief, urology, Oregon Health & Science University, Portland; Andrew Vickers, Ph.D., associate attending research methodologist, Memorial Sloan-Kettering Cancer Center, New York City; Thomas Neville, Ph.D., chief scientist and founder, Soar Biodynamics, Los Altos, Calif.
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