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PPD Updates 2007 Forecast; Issues Financial Guidance for 2008
Date:1/8/2008

- 65

Total company $1,290 - $1,340 $1,295 - $1,310 $1,535 - $1,590

EPS

Development $1.48 - $1.52 $1.45 - $1.47 $1.64 - $1.72

Discovery sciences (0.11) - (0.13) (0.09) 0.18 - 0.20

Total company $1.35 - $1.39 $1.36 - $1.38 $1.82 - $1.92

(1) Net revenue in millions, excludes reimbursed out-of-pocket expenses.

The 2008 guidance for the discovery sciences segment includes two projected milestone payments from the DPP-4 collaboration with Takeda Pharmaceutical Company Limited. First, PPD anticipates that the FDA will accept the recently filed new drug application, or NDA, for Takeda's lead DPP- 4 candidate, alogliptin, in the first quarter of 2008. If this occurs, PPD will earn a $15.0 million milestone payment from Takeda. Second, PPD is forecasting the approval of the NDA for alogliptin in the fourth quarter of 2008, which would trigger a $25.0 million milestone payment from Takeda. Alogliptin, also referred to as SYR-322, is a highly selective dipeptidyl peptidase-IV inhibitor that is being developed by Takeda for the treatment of type 2 diabetes.

The effective tax rate for 2008 is projected to be in the range of 33 to 34 percent, compared to an expected rate of 34 percent for 2007.

Projected capital expenditures for 2008 are expected to be in the range of $80 to $90 million. These expenditures will be associated with facility expansions and improvements, as well as investments in information technology and new laboratory equipment.

"For 2008, we expect to see steady growth in the core development business, and plan to continue to focus our efforts on disciplined execution throughout the year," said Fred Eshelman, chief executive officer of PPD. "We are particularly excited about the potential maturation of the DPP-4 program with Takeda. In addition, we look forward to the continued advancement of our other compound partnering arrangement
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SOURCE PPD, Inc.
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