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PLC Medical Systems Announces Publication of Care Study Update
Date:7/16/2009

FRANKLIN, Mass., July 16 /PRNewswire-FirstCall/ -- PLC Systems Inc. (OTC Bulletin Board: PLCSF), a company focused on innovative cardiac and vascular medical device-based technologies, today announced that a follow-up study of the landmark Cardiac Angiography in Renally Impaired Patients (CARE) Study determined that Contrast-Induced Nephropathy (CIN) is associated with long-term adverse events, ranging from pulmonary edema to death, and that patients with CIN were twice as likely as those who did not develop CIN to experience adverse events.

The study was published in the June 25, 2009 issue of the Clinical Journal of the American Society of Nephrology (CJASN). This study, authored by Dr. Richard J. Solomon, Professor of Medicine, University of Vermont College of Medicine, et.al., followed more than 70 percent of the original subjects of the CARE study. Dr. Solomon is a member of the Scientific Advisory Board for PLC Medical Systems, and is one of the principal investigators for PLC's FDA-approved pivotal trial for RenalGuard in the U.S.

Mark R. Tauscher, president and chief executive officer of PLC Systems, said, "CIN is a significant and growing concern worldwide, and the publication of this study adds scientific weight to the need to find a way of preventing it. We continue to be very encouraged by the work of scientists who are studying our RenalGuard System((R)), which we believe could be an effective solution in reducing the incidence rate of CIN."

Currently, RenalGuard((R)) is the subject of an investigator-sponsored trial to study its efficacy in mitigating against CIN at the University of Milan-Centro Cardiologico Monzino (CCM). This trial is designed to assess RenalGuard compared to standard overnight hydration, a prevalent method of treatment in the EU, in preventing CIN in patients undergoing cardiac catheterization procedures and percutaneous coronar
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