Navigation Links
PI3K/mTOR pathway proteins tied to poor prognosis in breast cancer
Date:4/1/2012

CHICAGO - Four proteins involved in translation, the final step of general protein production, are associated with poor prognosis in hormone-receptor-positive breast cancer when they are dysregulated, researchers reported at the AACR Annual Meeting 2012.

All of the aberrantly activated translational proteins are regulated by the PI3K/mTOR molecular signaling pathway, which has been implicated in development and progression of several cancers.

More recently, mTOR activation has been tied to resistance to standard endocrine therapy in estrogen-receptor positive breast cancer, said Funda Meric-Bernstam, M.D., professor in MD Anderson's Department of Surgical Oncology, who presented the research at AACR.

"These data underline the importance of the PI3K/mTOR pathway in hormone receptor-positive breast cancer and suggest potential new prognostic factors and therapeutic targets," said Meric-Bernstam, who also is medical director of MD Anderson's Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy.

Two drugs that inhibit mTOR, everolimus and temsirolimus, are approved for treatment of certain cancers and there are dozens of other agents in clinical trials, she said.

Cancer cells rely on increased protein synthesis

Genes express messenger RNA, which is in turn processed through a cell's ribosomes to produce a specific protein, a step called translation.

"Cancer cells need a lot of protein synthesis to grow and survive," Meric-Bernstam said. She and colleagues systematically analyzed several major translation-regulating proteins in tumors from 190 patients with stage 1 to stage 3 hormone receptor-positive breast cancer. Median follow-up was 96 months.

They found four aberrations that were predictors of overall survival. They remained significant even after multivariable analysis accounting for other factors such as age and node-positive status that also affect s
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists link 2 cancer-promoting pathways in esophageal cancer
2. Pancreatic Cancer Action Network-AACR Pathway to Leadership grants
3. PCP genetic pathway acts as stop sign for cell growth
4. New pathway found for regulation of blood vessel growth in cancer
5. Boston University research suggests new pathways for cancer progression
6. Possible new pathway can overcome glioblastoma resistance
7. Plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells
8. TGen researchers map potential genetic origins, pathways of lung cancer in nonsmokers
9. MS May Take a Different Pathway Than Previously Thought
10. Traumatic injury sets off a genomic storm in immune system pathways
11. New gene study of ADHD points to defects in brain signaling pathways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... most persistent and deadliest infectious diseases in the world, ... Scientists who study tuberculosis have long debated its origins. ... in Africa to seals and sea lions that brought ... Native people there before Europeans landed on the continent. ... a Source of New World Human Tuberculosis," was published ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 As concerns ... of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological ... two U.S. Senators from New York are urging the ... recall of the devices. In a letter dated August ... also implored the agency to seriously consider the testimony ...
(Date:8/20/2014)... stimulates stress responses in adults, researchers at Yerkes ... that the amygdala has an inhibitory effect on ... primates. , The results are published this week ... amygdala is a region of the brain known ... and learning about threats. Alterations in the amygdala ...
(Date:8/20/2014)... HealthDay Reporter TUESDAY, Aug. 19, ... a baby,s immune system is twice as common as once ... says. This is the first evaluation of the effect ... as severe combined immunodeficiency (SCID), or "Bubble Boy" disease, the ... by the boy in the bubble, who was born without ...
(Date:8/20/2014)... CA (PRWEB) August 20, 2014 The main ... 12 per diode panel band perfect spectrum that encompasses the ... most likely to use during photosynthesis. A key point ... is that they almost exclusively reside between 440-480 on the ... the red side of the spectrum. The KIND LED K3 ...
Breaking Medicine News(10 mins):Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Maturing brain flips function of amygdala in regulating stress hormones 2Health News:Maturing brain flips function of amygdala in regulating stress hormones 3Health News:'Bubble Boy' Disease May Be More Common Than Thought 2Health News:'Bubble Boy' Disease May Be More Common Than Thought 3Health News:Cheap LED Grow Lights Are Quickly Being Replaced by Premium Grow Lights 2
... , FRIDAY, July 31 (HealthDay News) -- A gene associated ... blindness, has been identified by scientists. , The EphA2 gene ... of damaged proteins in the eye. Expression of the EphA2 ... together and cause the eye lens to become cloudy, resulting ...
... , , , LAWRENCE, ... ), a leading manufacturer of innovative dialysis products, today announced that ... Canaccord Adams Global Growth Conference on Tuesday, August 11, 2009 at ... NxStage,s investor presentation is scheduled for Tuesday, August 11th at 10:00 ...
... , , WOODLAND HILLS, Calif., ... provider of advertising and marketing opportunities for national brands in health ... (NYHRC) chain has agreed to join its network. , ... HCMN will immediately begin installation of its static and digital panel ...
... , CHENNAI, India, July 31 ... Children,s Hospital, the,First Standalone Quaternary Care Paediatric Hospital in the ... ) , The Apollo Children,s ... adolescents up to the age of 16 years all,under one ...
... ... section featuring the latest news and trends from the "wellness" world. , ... Seattle, WA (PRWEB) July 31, ... and sleep-deprived society, alternative medicine and natural health have become a great alternative to ...
... ... to disseminating information on dentistry,s role in the recognition and management of snoring and sleep ... the second month in a row. , ... New York, NY (PRWEB) July 31, 2009 -- Snoring Isn,t Sexy, LLC, a ...
Cached Medicine News:Health News:NxStage to Present at the Canaccord Adams Global Growth Conference 2Health News:Health Club Media Network Adds New York Health & Racquet Club 2Health News:Oscar Award Winner, Dr. A.R. Rahman inaugurates Apollo Children's Hospital - the First Standalone Quaternary Care Paediatric Hospital in the Apollo Hospitals Group 2Health News:Natural Healers Launches "Wellness Community Bulletin" 2Health News:Natural Healers Launches "Wellness Community Bulletin" 3Health News:Natural Healers Launches "Wellness Community Bulletin" 4Health News:SnoringIsntSexy.com Tops 21,000 Site Visits for Second Month in a Row 2
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com ... is available in its catalogue: ... Key Trends and Opportunities to 2018 ... Synopsis The report provides in depth market ... personal accident and health insurance segment, including: ...
(Date:8/20/2014)... -- Children aren,t the only segment of our ... disease. The Centers for Disease Control and Prevention ... many adults are not following this advice. ... and the American Lung Association in partnership with ... disease, to talk with their health care provider ...
(Date:8/20/2014)... -- Research and Markets has announced ... Care and Closure Market (Types, Applications, End User ... Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation ... their offering. The new report ... (types, applications, end user and geography) - Size, ...
Breaking Medicine Technology:Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 3Global Advanced Wound Care and Closure Market (Types, Applications, End User and Geography) - Forecast to 2020 2
... Coast Dental Services, Inc., announced today that it ... of Dental Technology, Inc. (DTI), doing business as SmileCare, ... care service plan. DTI and its subsidiaries operate 57 ... 1,200 staff members, including 130 dentists.  The transaction is ...
... The Food and Drug Administration says some companies are ... falsely claim to treat, prevent, or cure STDs. Are ... big risk unless you see a healthcare provider who ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) View a video, slideshow, and ...
Cached Medicine Technology:Coast Dental to Acquire the Assets of SmileCare 2
Female Mini-VEST, Front Closure, X-Firm...
For Lipoplasty or surgery of abdomen, flanks and midriff...
Female High Waist Briefs...
Short-Sleeve Bolero for targeted compression in the upper arms, back and shoulder areas. Plush-shielded hook and eye front closure for comfort and convenient application....
Medicine Products: