Navigation Links
PET tracer changes management plan for brain tumor patients

Reston, Va. (March 1, 2012) Imaging amino acid transporters with positron emission tomography/computed tomography (PET/CT) has been shown to significantly alter intended management plans for patients with brain tumors, according to research in the March issue of The Journal of Nuclear Medicine. As a result of imaging with the radiopharmaceutical 3,4-dihydroxy-6-F-18-fluoro-L-phenylalanine (F-18-DOPA), physicians changed the intended management plan for 41 percent of patients with brain tumors.

Contrast-enhanced magnetic resonance imaging (MRI) is most frequently used to diagnose and monitor patients with brain tumors. After initial treatment, however, the assessment of recurrence by MRI can be difficult since contrast enhancement cannot reliably distinguish tumor recurrence from radiation necrosis. PET/CT imaging provides a highly accurate image that is beneficial for detecting primary and recurrent high- and low-grade brain tumors.

In the study, "Impact of 3,4-Dihydroxy-6-F-18-Fluoro-L-Phenylalanine PET/CT on Managing Patients with Brain Tumors: The Referring Physician's Perspective," referring physicians were given a survey prior to performing PET/CT scans with F-18-DOPA on patients with known or suspected brain tumors. The pre-scan surveys asked about indication, tumor histology or grade, level of suspicion for tumor recurrence and planned management. Soon after the PET/CT scans, the referring physicians were asked to complete a survey to categorize PET findings, level of suspicion for primary or recurrent brain tumors and intended management changes. Six months following the scans, the physicians took another survey dealing with recurrence and survival.

Of the 58 cases that were included in the survey, the clinical suspicion for recurrence increased in 33 percent, remained unchanged in 50 percent and decreased in 17 percent of patients after adding the PET/CT findings to other diagnostic data. As a result, several changes in management were recommended, with changes from "watch and wait" to chemotherapy (25 percent) and from chemotherapy to "watch and wait" (17 percent) occurring most frequently. Seventy-five percent of the recommended changes were implemented.

"We know that F-DOPA PET/CT imaging is highly accurate for detecting brain tumors, and in our research we've shown that this imaging modality has a significant impact on patient management," said Johannes Czernin, MD, one of the authors of the study. "In the future, we will initiate multicenter trials to determine whether these management changes have an impact on patient outcome. We believe that amino-acid transport imaging with PET will eventually be an important and frequently used imaging modality in brain cancer."

According to the American Brain Tumor Association, an estimated 64,530 new cases of primary brain tumors were expected to be diagnosed last year. It is estimated that during the year 2004 more than 612,000 people in the United States were living with the diagnosis of a primary brain or central nervous system tumor. The five year survival rates vary among tumor subtypes and range from 3.3 percent for high-grade tumors to 70 percent for low-grade tumors.


Contact: Susan Martonik
Society of Nuclear Medicine

Related medicine news :

1. Groundbreaking Study Using Ultrasound for the Treatment of Intracerebral and Intraventricular Hemorrhage Stroke Shows Promise
2. Novel radiotracer shines new light on the brains of Alzheimers disease patients
3. Physical Changes in Brain Linked to Altered Spirituality
4. Northern California Cancer Center Changes Name to Cancer Prevention Institute of California
5. Medicare Advantage Members May Make Changes During Open Enrollment
6. CMS Watch Changes Name to The Real Story Group
7. Changes during menopause increases risk of heart disease and stroke
8. Childhood stress such as abuse or emotional neglect can result in structural brain changes
9. Dmatek Changes its Name to Attenti
10. Long Island Pediatric Group Announces Policy Changes That Will Help More New Yorkers
11. Changes the Way People Lose Weight by Offering an Affordable HCG Diet Plan
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... ... Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate ... primary prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. ...
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)...   West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today shared the results of a study highlighting ... intradermal administration of polio vaccines. The study results were ... 2017 by Dr. Ondrej Mach , Clinical Trials ... (WHO), and recently published in the journal Vaccine. ...
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
Breaking Medicine Technology: