Navigation Links
PET scans predict effectiveness of treatment for multidrug-resistant tuberculosis in HIV patients
Date:5/24/2011

Reston, Va. With the deficiencies in knowledge of tuberculosisas well as in the practices, programs and strategies used to combat the disease and co-infection with human immunodeficiency virus (HIV)the spread of multidrug-resistant (MDR) tuberculosis poses a major problem for the health care community. Research in the June issue of The Journal of Nuclear Medicine, however, shows that the use of 18F-FDG positron emission tomography (PET) scans can help to determine earlier if treatment for tuberculosis is working or if the disease is MDR.

Tuberculosis and HIV have been linked since the AIDS epidemic began. Approximately 33.2 million people across the world are living with HIV, and an estimated one-third of them are co-infected with tuberculosis. In 2008, the number of MDR tuberculosis cases reached between 390,000-510,000, or 3.6 percent of all incident tuberculosis cases. MDR tuberculosis is very difficult to treat and is often fatal.

"Early detection of drug resistance of tuberculosis allows the initiation of an appropriate treatment, which may significantly affect patient survival. Currently, more than two-thirds of patients with MDR tuberculosis die," said Mike Sathekge, MD, PhD, lead author of the study "Use of 18F-FDG PET to Predict Response to First-Line Tuberculostatics in HIV-Associated Tuberculosis."

In the prospective pilot study, 24 patients with tuberculosis underwent 18F-FDG PET scans prior to receiving tuberculosis treatmentthe standard triad: isoniazid, rifampicin and ethambutol. After four months of treatment, the patients received another 18F-FDG scan to measure averaged maximum standardized uptake value (SUVmax)which measures glucose metabolic activityderived from early and delayed imaging, percentage change in SUVmax and number of involved lymph node basins.

The researchers found that SUVmax of involved lymph nodes, number of involved lymph node basins and C-reactive protein levels assessed by the PET scan were significantly higher in nonresponders than responders. It was determined that a cutoff of five or more lymph node basins allowed for a separation of treatment responders and nonresponders.

According to Sathekge, "18F-FDG PET has the potential to become a valuable clinical adjunct to the already available genotypic and phenotypic tests in patients for whom such tests are not feasible, are inconclusive or are too lengthy to be of clinical relevance."


'/>"/>

Contact: Susan Martonik
smartonik@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. FDA Seeks Reduction in Radiation From Medical Scans
2. New Heart CT Scans Deliver Far Less Radiation: Study
3. Scans Might Monitor Success of Alzheimers Drugs
4. Brain scans could be marketing tool of the future
5. Scans May Be Misleading for Hockey Players
6. Scans of brain networks may help predict injurys effects
7. CT and MRI scans associated with shorter hospital stays and decreased costs
8. Fear of getting fat seen in healthy womens brain scans
9. Researchers successfully lower radiation dose associated with pediatric chest CT scans
10. Summit aims to develop guidelines for safe and effective CT scans
11. Simple reduction technique decreases radiation dose associated with CT scans of the head
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... LINCOLN, R.I. (PRWEB) , ... April 28, 2017 , ... Getting enough sleep affects much ... Sleep Foundation (NSF), going just 19 hours without sleep can compromise motor reaction time, which ... Awareness Week, and Amica Insurance is sharing the following tips from the NSF to help ...
(Date:4/28/2017)... ... April 28, 2017 , ... Date aired: ... , “Computers are everywhere and they’re here to stay,” said Sharon Kleyne on ... and Your Health on Voice America sponsored by Nature’s Tears® EyeMist®. So she ...
(Date:4/28/2017)... ... April 28, 2017 , ... The Radiology Business Management Association (RBMA) ... 2017-2018. The annual board election process has been in place since the RBMA was ... C. Dickerson, Ed.D., FACHE, succeeds Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson ...
(Date:4/28/2017)... ... April 28, 2017 , ... Children and adolescents who ... experiences than children in the general population. That’s because foster care is designed ... family challenges. While no fault of their own, youth who have experienced trauma ...
(Date:4/28/2017)... ... April 28, 2017 , ... From ... College of Urgent Care Medicine will host industry leaders for the annual spring ... help those in the industry adapt to the issues currently affecting urgent care ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... The Mobile X-Ray product segment is the most attractive market ... period Mobile X-Ray segment is the largest segment ... market, which is estimated to be valued at more than ... 7% over the forecast period. Mobile X-Ray segment is expected ... Mn in 2017 over 2016. The segment,s revenue in the ...
(Date:4/19/2017)... 2017 Global Prostate Cancer Therapeutics Market: ... prostate cancer therapeutics market analyzes the current and ... of prostate cancer, launch of promising emerging therapies, ... new drugs & therapeutic biological products, and high ... lesser side effects are some of the drivers ...
(Date:4/19/2017)... , April 19, 2017  Sorrento Therapeutics, ... antibody-centric, clinical-stage biopharmaceutical company developing new treatments for ... the closing of its previously announced underwritten public ... at a public offering price of $2.00 per ... estimated offering expenses payable by Sorrento.  The net ...
Breaking Medicine Technology: