Navigation Links
PET scans predict effectiveness of treatment for multidrug-resistant tuberculosis in HIV patients

Reston, Va. With the deficiencies in knowledge of tuberculosisas well as in the practices, programs and strategies used to combat the disease and co-infection with human immunodeficiency virus (HIV)the spread of multidrug-resistant (MDR) tuberculosis poses a major problem for the health care community. Research in the June issue of The Journal of Nuclear Medicine, however, shows that the use of 18F-FDG positron emission tomography (PET) scans can help to determine earlier if treatment for tuberculosis is working or if the disease is MDR.

Tuberculosis and HIV have been linked since the AIDS epidemic began. Approximately 33.2 million people across the world are living with HIV, and an estimated one-third of them are co-infected with tuberculosis. In 2008, the number of MDR tuberculosis cases reached between 390,000-510,000, or 3.6 percent of all incident tuberculosis cases. MDR tuberculosis is very difficult to treat and is often fatal.

"Early detection of drug resistance of tuberculosis allows the initiation of an appropriate treatment, which may significantly affect patient survival. Currently, more than two-thirds of patients with MDR tuberculosis die," said Mike Sathekge, MD, PhD, lead author of the study "Use of 18F-FDG PET to Predict Response to First-Line Tuberculostatics in HIV-Associated Tuberculosis."

In the prospective pilot study, 24 patients with tuberculosis underwent 18F-FDG PET scans prior to receiving tuberculosis treatmentthe standard triad: isoniazid, rifampicin and ethambutol. After four months of treatment, the patients received another 18F-FDG scan to measure averaged maximum standardized uptake value (SUVmax)which measures glucose metabolic activityderived from early and delayed imaging, percentage change in SUVmax and number of involved lymph node basins.

The researchers found that SUVmax of involved lymph nodes, number of involved lymph node basins and C-reactive protein levels assessed by the PET scan were significantly higher in nonresponders than responders. It was determined that a cutoff of five or more lymph node basins allowed for a separation of treatment responders and nonresponders.

According to Sathekge, "18F-FDG PET has the potential to become a valuable clinical adjunct to the already available genotypic and phenotypic tests in patients for whom such tests are not feasible, are inconclusive or are too lengthy to be of clinical relevance."


Contact: Susan Martonik
Society of Nuclear Medicine

Related medicine news :

1. FDA Seeks Reduction in Radiation From Medical Scans
2. New Heart CT Scans Deliver Far Less Radiation: Study
3. Scans Might Monitor Success of Alzheimers Drugs
4. Brain scans could be marketing tool of the future
5. Scans May Be Misleading for Hockey Players
6. Scans of brain networks may help predict injurys effects
7. CT and MRI scans associated with shorter hospital stays and decreased costs
8. Fear of getting fat seen in healthy womens brain scans
9. Researchers successfully lower radiation dose associated with pediatric chest CT scans
10. Summit aims to develop guidelines for safe and effective CT scans
11. Simple reduction technique decreases radiation dose associated with CT scans of the head
Post Your Comments:
(Date:11/27/2015)... ... 2015 , ... Dr. Thomas Dunlap and Dr. Patrick Coleman ... with Emergency Medicine at St., Joseph Health System’s Santa Rosa Memorial Hospital , ... in similar ways and require time-critical intervention to avoid large area heart damage and ...
(Date:11/27/2015)... ... , ... Indosoft Inc., developer and distributor of the world-class ... (Long Term Support) into its Q-Suite 5.10 product line. , Making the change ... version of Asterisk that will receive not only security fixes, but feature and ...
(Date:11/26/2015)... , ... November 26, 2015 , ... Inevitably when people ... customers choose to buy during the Black Friday and Cyber Monday massage ... need to search the Internet high and low to find the best massage chair ...
(Date:11/26/2015)... ... 26, 2015 , ... Somu Sivaramakrishnan announced today that he ... now offers travelers, value and care based Travel Services, including exclusive pricing on ... as, cabin upgrades and special amenities such as, shore excursions, discounted fares, travel ...
(Date:11/26/2015)... ... November 26, 2015 , ... Jobs in hospital medical laboratories and in the ... healthcare staffing agency Aureus Medical Group . These fields, as well ... those searching for healthcare jobs through the company’s website, , The ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 26, 2015 ... the "2016 Global Tumor Marker Testing ... and Sales Segment Forecasts, Innovative Technologies, Instrumentation ... to their offering. --> ... "2016 Global Tumor Marker Testing Market: ...
(Date:11/26/2015)... , November 26, 2015 ... new combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for ... combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced ... combination approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced ... has found that immunotherapy can be efficiently combined ...
(Date:11/26/2015)... 2015 3D bioprinting market is ... a new report by Grand View Research Inc. Rising prevalence ... demands kidney transplantation is expected to boost the market growth, ... organ transplantation. --> 3D bioprinting market is ... a new report by Grand View Research Inc. Rising prevalence ...
Breaking Medicine Technology: