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PET scans lead to treatment changes in majority of colorectal cancer patients
Date:9/1/2008

Reston, Va.In the largest multi-institutional study to date examining the impact of positron emission tomography (PET) in changing disease management of individuals with suspected recurrent colorectal cancer, researchers found that treatment plans were changed for more than half of patients, according to an article in the September issue of The Journal of Nuclear Medicine.

The study was conducted at four sites throughout Australia and comprised 191 patients who were divided into two groups. Group A consisted of symptomatic patients who had residual structural lesions suspicious for recurrent tumor after initial therapy. Group B comprised patients with pulmonary or hepatic metastases that were potentially operable. These results were compared with findings from conventional imaging (such as computed tomography or CT), and participants were followed for 12 months.

"Designed with an evidence-based approach, this study confirmed the important role PET plays in the decision-making process of patients with colorectal cancer and the impact of PET on both the management and outcome of disease," said Andrew M. Scott, M.D., director of the Centre for PET and the Ludwig Institute for Cancer Research, Austin Hospital, Melbourne, Australia. "These results are compelling and indicate that PET should be made more widely available to patients."

Based on the extent and progression of disease revealed by the scans, treating physicians changed the planned management in more than 65 percent of patients in group A and nearly 50 percent in group B. The researchers also found additional disease sites in 48 percent of group A and 44 percent in group B, providing valuable prognostic information about patients that allowed their stratification into curative or palliative groups.

"PET was able to identify those patients who had potential for long-term, progression-free survival and even a potential cure," said Scott. "Just as important, it ident
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Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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