Navigation Links
PET scanning probes reveal different cell function within the immune system
Date:5/18/2010

A commonly used probe for Positron Emission Tomography (PET) scanning and a new probe developed by researchers at UCLA reveal different functions in diverse cells of the immune system, providing a non-invasive and much clearer picture of an immune response in action.

The probes, the commonly used FDG that measures cellular glucose metabolism, and FAC, developed at UCLA and which measures the activity of a distinct biochemical pathway, work better when used in combination than either does alone. In addition to revealing the extent and cellular composition of an immune response, the probes also may be useful in evaluating therapies that target different cellular components of the immune system, said Dr. Owen Witte, a professor of microbiology, immunology and molecular genetics, a Howard Hughes Medical Institute investigator and senior author of the study.

"We demonstrated with this study that each probe targets different cells in the immune system with a high degree of specificity," said Witte, director of the UCLA Broad Stem Cell Research Center and a Jonsson Cancer Center researcher. "When cells are activated to do their job as an immune cell, the FDG probe is good at recognizing the subset of activated macrophages, while the FAC probe is good at recognizing the activated lymphocytes, as well as the macrophages. When tested sequentially, the combined information from the scans using the two probes gives you a better status of immune response."

The study, with lead author Evan Nair-Gill, a student in the campus' Medical Scientist Training Program, was conducted on mice bearing virally-induced sarcomas. The article appears today in the early online edition of the Journal of Clinical Investigation. Testing the probes in humans is the next step.

The scans provide clues to how the immune system works, for example, in response to cancer or auto-immune diseases such as rheumatoid arthritis, inflammatory bowel disease and
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Symposium focuses on patient safety in CT scanning
2. New form of endoscopic scanning improves detection of precancerous condition
3. Scanning for skin cancer: Infrared system looks for deadly melanoma
4. New e-Forms Management Tools from Access Bridge the Gap Between MEDITECH Magic and Scanning and Archiving for Hospitals
5. SecureWorks Extends PCI Approved Scanning Vendor Solutions
6. Lab that probes genetic clues to disease is poised for major expansion
7. Fluorescent probes light up cancerous tumors
8. Epione Reveals a ‘Bright' New Solution for Dull, Sun Damaged Skin
9. Independent Study Reveals Family Bonds made Stronger on Vacations where Animals are Involved
10. Statistics Reveal Women Choose Engagement Rings Before Men
11. Mayo Clinic study reveals neighborhood asthma risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Dr. Henry H. Ting, a nationally recognized ... appointed senior vice president and chief quality officer at ... role, he will oversee the hospital's clinical quality and ... quality initiatives and interprofessional teams at the local, regional ... Door-to-Balloon Alliance, a collaboration of more than 1,000 hospitals ...
(Date:7/24/2014)... breast tumors, exposure to dim light at night made ... according to data published in Cancer Research , ... The negative effects of dim light exposure on tamoxifen ... during the night. , "Resistance to tamoxifen is a ... said Steven M. Hill, PhD, professor of structural and ...
(Date:7/24/2014)... 25, 2014 Voted one of the ... global clients, BellasDress focuses on providing its new and ... information. Recently, the company has announced its new collection ... new range is created according to the latest fashion ... up to 68% off. , As a matter of ...
(Date:7/24/2014)... The report, “Content Delivery Networks (CDN) Market”, defines ... with an in-depth analysis and forecasting of revenues. ... this market with insights on trends, opportunities, and ... 36 figures spread through 157 pages and in-depth ... http://www.marketsandmarkets.com/Market-Reports/content-delivery-networks-cdn-market-657.html . , Early buyers will ...
(Date:7/24/2014)... July 24, 2014 Just as fitness ... must consider their own financial and marketing strength to ... marketing campaigns to the next level by using the ... Center, IVR, Voice Broadcast, Call Tracking and SMS ... open rate, text messages are quickly become integral in ...
Breaking Medicine News(10 mins):Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 2Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 3Health News:Exposure to dim light at night may make breast cancers resistant to tamoxifen 2Health News:BellasDress Helps Brides Get High End Wedding Dresses for Their Romantic Weddings 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Pump Up Your Gym’s Marketing Muscles with Mobile Marketing: CallFire's Health & Fitness Webinar Week – July 28th to August 1st 2Health News:Pump Up Your Gym’s Marketing Muscles with Mobile Marketing: CallFire's Health & Fitness Webinar Week – July 28th to August 1st 3
... Short-course (DOTS) tuberculosis control programme will cover the entire country ... here Sunday.//, ,"The drugs for the DOTS programme will ... remote areas," said the minister at a function here to ... ,The facility has come up at the Tuberculosis Research ...
... In China people's attitudes toward sex has completely changed. Chinese ... (LAT). In this one can life the life of a ... does not desires to stay together and that the partner ... agreement includes that neither of them is obliged to have ...
... out that babies breastfed for six months have reduced ... research was conducted by investigators at UC Davis Children's ... of Pediatrics, Center for Child Health Research. ... UC Davis Children's Hospital, lead author, "We found that ...
... 'dead regions' in the brain that could be responsible ... Karolina Kluk, a Cambridge University student. // The finding ... aids for children. ,The currently available methods ... a range of tones or bleeps. This however, cannot ...
... birth control patch are twice as likely to develop clots in ... Recently, another study conducted on similar grounds // has revealed that ... women who use the patch have been urged to discus their ... ,Women who use the patch may be at an increased risk ...
... clinical trial of administering xenon gas to patients undergoing ... safe from // the brain damage that occurs post ... xenon gas to 12 patients undergoing CABG on cardiopulmonary ... treat patients suffering from strokes in whom brain damage ...
Cached Medicine News:Health News:Sex a commonplace in Chinese life 2Health News:New Test Offers Hope in Effective Hearing Aid Design for Babies 2Health News:Xenon Could Limit Nerve Damage After Stroke 2
(Date:7/24/2014)... , July 24, 2014  In any given hospital ... 25 patients has at least one hospital-acquired infection, according ... more, many of these infections prove fatal. And as ... alarming number of patient deaths per year, infection control ... Consequently, a stronger emphasis is being ...
(Date:7/24/2014)... Boston Children,s Hospital,s Global Pediatric Summit + Awards, ... Tank" – a forum designed to give pediatric health ... product solution to a panel of acclaimed judges for ... the innovation and bring it to market. ... will be moderated by Daymond John of ...
(Date:7/24/2014)... -- Cancer patients in the west of Scotland ... to home when a new radiotherapy center opens near ... VAR ) has been selected to equip the ... four TrueBeam™ medical linear accelerators. Two of ... and radiosurgery treatments, will replace older treatment machines at the ...
Breaking Medicine Technology:Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 2Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 3Taking on Tomorrow to Feature "Innovation Tank" Pitch Opportunity for Aspiring Pediatric Health Care Entrepreneurs 2Taking on Tomorrow to Feature "Innovation Tank" Pitch Opportunity for Aspiring Pediatric Health Care Entrepreneurs 3Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 2Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: