Navigation Links
PET/CT brings new hope to patients with deadly form of breast cancer
Date:11/27/2007

CHICAGO Researchers are improving the chances of women faced with an aggressive and difficult to diagnose form of breast cancer. Inflammatory breast cancer spreads quickly and can be lethal in six to nine months. But by using fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT), radiologists and physicists are able to spot the spread of cancer earlier, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

PET/CT is useful in staging inflammatory breast cancer, because it provides information on both the primary disease site, as well as disease involvement throughout the rest of the body, said Selin Carkaci, M.D., assistant professor of diagnostic radiology at The University of Texas M. D. Anderson Cancer Center (UTMDACC) in Houston. In addition, PET/CT is also a practical tool for therapeutic planning.

Inflammatory breast cancer is a rare but extremely aggressive form of breast cancer that doesnt present like other forms of breast cancer. It accounts for 1 to 5 percent of all breast cancer cases in the United States. The disease tends to be diagnosed in women at a younger age and is characterized by redness, swelling or warmth in the breast. These symptoms occur within a three-month period. Often there is no palpable lump, and by the time it is diagnosed, the cancer has already metastasized, or spread, reducing the chances for survival. According to the American Cancer Society, the five-year survival rate for patients with inflammatory breast cancer is only 25 to 50 percent.

With FDG-PET/CT, researchers are able to accurately determine the location of metastases early in the disease process, when appropriate treatment can be administered.

Breast cancer is not a local problem, said co-author Homer A. Macapinlac, M.D., chair and professor of nuclear medicine at UTMDACC. It is a systemic disease.

The study included 41 women, mean age 50 years, who were newly diagnosed with inflammatory breast cancer. Each patient underwent a whole-body FDG-PET/CT exam.

FDG-PET/CT depicted metastases in 20 patients (49 percent). These findings were confirmed by biopsy and supplementary imaging. FDG-PET/CT produced only two false positive results, identifying those areas as cancerous when in fact no disease was present, resulting in a 95 percent accuracy rate. The PET/CT scans were also able to identify instances of cancer involvement in the patients lymph nodes with 98 percent accuracy.

By performing PET/CT early in the treatment of inflammatory breast cancer, physicians can determine the effectiveness of the therapeutic regimen and make changes as needed.

PET provides information about how the body is functioning at the cellular level, while CT provides an anatomical rendering of the inside of the body. In an FDG-PET/CT scan, the CT first produces detailed images of the inner anatomy of the body. The patient is then injected with a small amount of a radioactive drug, which is F-18-labeled glucose, and PET is performed. Because fast-growing cancer cells feed on sugars like glucose, the PET/CT delineates areas where the glucose accumulates in the body, pinpointing the location of cancer cells.

Whats exciting about PET/CT is that it is able to detect disease in its earliest stages, when changes are happening at a functional and cellular level, Dr. Carkaci said. This is quite different from other imaging modalities that identify disease when there is destruction of normal anatomy.

M. D. Andersons Inflammatory Breast Cancer Clinic and Research Program, which opened in July 2007, is the worlds first clinic devoted to research, diagnosis and treatment of the disease.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. 18F-DG PET/CT can highly increase the detection of colorectal cancer
2. PET/CT Brings New Hope to Patients With Deadly Form of Breast Cancer
3. Vitamin Relief Brings Needed Nutrition to School District Resurrecting After Katrina
4. Naked Juice Brings Consumers Happiness by the Billions With First 100% Juice Smoothie Containing Probiotics
5. Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During America on the Move Week With the YMCA, September 22-29, 2007
6. PSI Brings its Pioneering Efforts to a Close
7. Serta Brings Sweet Dreams and a Special Delivery to Deserving Women
8. Eclipsys User Network Brings Eclipsys Clients Together to Share Outcome Improvement Strategies
9. Governor Rendell Brings Tour to Insure to Scranton and Urges Passage of Plan to Give Access to Affordable Health Insurance
10. New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs
11. IncentOnes Sue Lewis brings "The Art and Science of Incentive Management" to AHIP Business Forum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 2016 , ... W.S. Badger Co. Inc ., the maker of certified ... Work Works Award for its use of effective workplace strategies to increase business and ... administered by the Families and Work Institute (FWI) and the Society for Human Resource ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... and clinical outcomes, hosted members and suppliers for its inaugural Member Conference at ... on their mission of elevating the operational health of America’s healthcare providers. , ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... Connor ... women’s basketball as a partner for the Tamika Catchings Legacy Tour that ... the industry leader in hardwood basketball surfaces in all forms and levels of the ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Woodlands at John ... a new model of care for living and healing, celebrated its grand opening, today. ... in a Real Home provided by Empowered Staff. , “This is an incredibly fulfilling ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... There are ... more than 32 million cancer survivors worldwide. On Sunday, June 5, 2016, communities around ... annual National Cancer Survivors Day®. , National Cancer Survivors Day® is an annual ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016   , Study ... overall bowel cleansing and superiority in , ... of the ascending colon ... Norgine B.V. today announced new positive data from the ... bowel preparation) versus standard 2 litre PEG with ascorbate. The study ...
(Date:5/24/2016)... LAWRENCEVILLE, N.J. , May 24, 2016 /PRNewswire/ ... an oncology drug development company, today provided an ... Ib dose escalating clinical trial combining GEN-1, the ... for the treatment of newly-diagnosed patients with advanced ... by interval debulking surgery.  GEN-1 is an IL-12 ...
(Date:5/24/2016)... KONG , May 24, 2016 /PRNewswire/ ... COMBO ™ , la première ... des cathéters destinés à l,intervention portant sur ... (FAV)   OrbusNeich, entreprise mondiale ... permettant de changer la vie, a élargi ...
Breaking Medicine Technology: