Navigation Links
PDL-1 antibody could help immune system fight off influenza viral infection, study suggests
Date:12/23/2013

An antibody that blocks a component of a key signaling pathway in the respiratory airways could help the immune system rid the body of the influenza virus, a new study suggests. The findings, from a team at The Research Institute at Nationwide Children's Hospital, not only offer a new approach to treating the flu, but also add new information about how the immune system responds to respiratory viral infections.

In this new work, published in the December issue of the Journal of Virology and highlighted in the journal Spotlight section, researchers examined the role a protein called programmed cell death receptor (PD-1) plays in the immune response to influenza virus. PD-1 is known to inhibit the function of T cells, the immune system's first line of defense against intracellular pathogens. While scientists have looked intently at PD-1 activity in chronic viral infections such as hepatitis and HIV, its involvement in acute infections was thought by many to be minor.

Emilio Flao, PhD, principal investigator in the Center for Vaccines and Immunity, disagreed. Several small studies in his lab had raised the possibility that PD-1 and its associated ligand PDL-1 were actually very important to the immune response to acute infection.

The researchers' earlier studies had shown that when PD-1 protein was expressed, but its ligand PDL-1 was not, the protein couldn't bind to T cells to inhibit the immune response. So, for this study, the scientists treated mice infected with influenza virus with an antibody that blocks the activity of PDL-1. Viral levels began to drop within three days of treatment with the PDL-1 antibody, which was administered intranasally. At day five, the viral levels were undetectable.

"The PDL-1 blockade is not directly acting on the virus," Dr. Flao says. "It is acting on the T cells, improving their function so that the immune system can fight the virus."

When they examined the PD-1/PDL-1 response to influenza virus infection in human cell cultures, the scientists discovered that the activity of the protein and its ligand mimicked what they had seen in their mouse models. The findings from this study, coupled with the human tissue observations in the lab, suggest that an aerosolized version of the antibody, administered intranasally, could help the body clear the influenza virus.

"Sometimes it's better to enhance our own defenses and improve how they work rather than trying to target the virus," Dr. Flao says.

Scientists have eyed a PD-1/PDL-1 blockade as a way to treat hepatitis, HIV and other persistent viral infections, but their efforts have so far yielded mixed results in humans. Using the blockade to boost immune response against influenza is a simpler task because the infection is localized to the airways, Dr. Flao hypothesizes.

Dr. Flao and colleagues were also interested in how epithelial cells in the airwaysthe main targets of the influenza virusrespond to the attack and how their reaction might influence the immune system over the course of an infection.

"The original view has been that epithelial cells aren't all that important, but we are trying to change that, says Dr. Flao, who also is an associate professor of pediatrics at The Ohio State University College of Medicine. "The epithelial cells help orchestrate all the subsequent immune response in the body, and I truly believe that what they do at the onset of infection will determine what happens one week or 10 days later, when the immune system is responding at full speed."


'/>"/>

Contact: Mary Ellen Peacock
maryellen.peacock@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
2. Scientists Pinpoint Antibody That May Be Specific to MS Patients
3. NIH scientists map first steps in flu antibody development
4. Elevated Antibody Levels May Predict Rheumatoid Arthritis Risk
5. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
6. Antibody-coated stents: Indication of disadvantages
7. Evolution in the antibody factory
8. Scientists ID Antibody That Might Boost Cancer Therapy
9. Your Autoantibody Profile Might Someday Help Spot Illness
10. Monoclonal antibody appears effective and safe in asthma Phase IIa trial
11. Healthcare Antibody Market Partnering Deals And Agreements Analysis in New Research Report at ReportsnReports
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
Breaking Medicine Technology: