Navigation Links
PD-like sleep and motor problems observed in α-synuclein mutant mice
Date:6/7/2013

Amsterdam, NL, 7 June 2013 The presence of Lewy bodies in nerve cells, formed by intracellular deposits of the protein α-synuclein, is a characteristic pathologic feature of Parkinson's Disease (PD). In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α-synuclein. By studying a strain of mice bred to overexpress α-synuclein via the Thy-1 promoter, scientists have found these mice develop many of the age-related progressive motor symptoms of PD and demonstrate changes in sleep and anxiety. Their results are published in the latest issue of Journal of Parkinson's Disease.

PD is the second most common neurodegenerative disorder in the United States, affecting approximately one million Americans and five million people worldwide. Its prevalence is projected to double by 2030. The most obvious symptoms are movement-related, such as involuntary shaking and muscle stiffness; non-motor symptoms, such as increases in anxiety and sleep disturbances, can appear prior to the onset of motor symptoms. Although the drug levodopa can relieve some symptoms, there is no cure intensifying the pressure to find an animal model that can help clarify the pathological processes underlying human PD and find new medications to treat the pathology and/or relieve symptoms.

Investigators at the National Institute on Aging compared wild type mice with specially bred mice that were transgenic for the A53T mutation of the human α-synuclein (SNCA) gene under the control of a human thymus cell antigen 1, theta (THY-1) promoter. As the mice aged, their motor performance on a rotarod test (which measures how long the mouse can remain on a rotating rod) became impaired and the length of their strides were significantly shorter than the wild type control mice.

The study also found that SNCA mice displayed fragmented nighttime activity pattern
'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
2. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
3. Depressed moms behavior may play role in infants sleep problems
4. Depressed Moms May Hinder Babies Sleep
5. Poor Sleep Heightens Ringing Ear Disease Symptoms: Study
6. Adjusting Your Attitude About Chronic Pain May Help You Sleep
7. Excessive sleepiness may be cause of learning, attention and school problems
8. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
9. Sleepwalking in Adults More Common Than Thought
10. Pediatric epilepsy impacts sleep for the child and parents
11. Parents Often Lose Sleep Over Childs Epilepsy, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... (PRWEB) October 01, 2014 Join the more ... Eating Disorder Treatment Center’s first ever charity golf tournament to ... people with eating disorders who cannot afford treatment. The tournament ... Club in Eureka, Mo. , The day-long event starts ... A reception and award dinner will begin at 5 p.m. ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Beverly Hills ... Kathleen Mojas is celebrating 20 years of private practice ... hundreds of people to achieve greater joy and fulfillment ... list of warning signs and suggestions for anyone who ... Mojas explains: “Believe it or not, it’s not ...
(Date:10/1/2014)... Jupiter, FL (PRWEB) October 01, 2014 ... Begley, Jr., scheduled to broadcast on Monday, October 20, ... In this episode, Innovations will go behind the scenes ... prevention programs. This segment will explore the practical help ... young adults, which teaches the warning signs of abuse, ...
(Date:10/1/2014)... 01, 2014 NoteSwift Inc., announced today ... 10.0, 12.1 and 13.0. NoteSwift is the bridge between ... to navigate and document clinical information at the point ... creating a patient note by more than half – ... major pain points providers state impedes EHR use according ...
(Date:10/1/2014)... Scientists at the University of Western ... immune system proteins has the power to knock out ... of the new study on their website. Click ... in the UWA School of Pathology and Laboratory Medicine ... with mesothelioma with promising results. , “A timed ...
Breaking Medicine News(10 mins):Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:Innovations to Explore Breakthroughs in Health and Wellness in Upcoming Episode Airing Monday, October 20, 2014 via Discovery Channel 2Health News:NoteSwift Joins Allscripts Developer Program 2Health News:NoteSwift Joins Allscripts Developer Program 3Health News:New Mesothelioma Study Says Mice Cured by Immuntherapy “Cocktail”, Reports Surviving Mesothelioma 2
... nitrogen-containing bisphosphonate (N-BP) cancer drugs, used to relieve bone ... has been almost entirely unknown. Researchers writing in BioMed ... used ,barcoded, yeast mutants to identify new biological processes ... opportunities for the development of new anticancer drugs. ...
... LOS ANGELES, Sept. 9 In commemoration of the first ... Red Cross of Greater Los Angeles will host three 2-hour volunteer orientations ... volunteers will receive a tour of the chapter,s new state of the ... Cross, response to the recent California wildfires. , , ...
... WASHINGTON, Sept. 9 Congressman Chaka Fattah (D-PA), a strong ... conclusion of President Obama,s address tonight to Congress and the nation: ... The time to act is now. We have been talking and ... of this 111th Congress. The American people have already voted: In ...
... , INDIANAPOLIS, Sept. 9 WellPoint, Inc. (NYSE: ... Medicare Advantage and 2010 Medicare Part D health benefit plans effective Oct. ... Medicare Part D health benefit plans on Nov. 15, 2009 for the ... Medicare and Medicaid Services (CMS) has determined that WellPoint has corrected deficiencies ...
... , DENVER, Sept. 9 DaVita Inc. (NYSE: ... for those diagnosed with chronic kidney disease (CKD), supports dialysis patients, ... standards and social circumstances. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20020729/DAVITALOGO ... your everyday student at Hollywood High School in Los Angeles, CA ...
... infection known as Trichomonas vaginalis is associated ... study published online September 9 in the Journal ... Stark, ScD, of the department of epidemiology at the ... conducted a case-control study nested within the Physicians, Health ...
Cached Medicine News:Health News:Red Cross Participates in September 11th National Day of Service and Remembrance 2Health News:Statement on WellPoint's Re-Entry into Medicare Market 2Health News:DaVita's Patient-Centric Modalities Offer Students with Kidney Disease More Choices 2Health News:JNCI news brief: STD confirmed to be associated with increased risk of prostate cancer 2
(Date:9/30/2014)... 2014 This study provides an analysis ... solutions including nuclear imaging informatics, PET imaging informatics, ... assesses the size of the market based on ... projects future growth based on the current drivers ... place in the broader markets for imaging equipment, ...
(Date:9/30/2014)... 2014  Decision Resources Group finds that the Asia ... China , India , ... rate through 2023. Dental implant procedure volumes will grow as physicians ... Other key findings from Decision Resources Group,s coverage of ... , Dental implant penetration: Penetration of dental implants among ...
(Date:9/30/2014)... -- A study using a relatively new imaging tool, ... the composition of carotid artery disease and has the ... disease, a leading cause of stroke. ... 2010 and May 2012, was featured in the June ... College of Cardiology (JACC) Cardiovascular Interventions. Interventional cardiologist ...
Breaking Medicine Technology:Analysis of the US Molecular Imaging Informatics Market 2Analysis of the US Molecular Imaging Informatics Market 3Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
... an interventional guidance device that uses ... the accuracy of computed tomography (CT)-guided ... accuracy, SimpliCT® also has the potential ... puncture procedures including biopsies and fluid ...
ELVeS™ (Endo Laser Vein System) from biolitec is a versatile, easy to use & complete system that allows you to treat all conditions resulting from venous incompetence. (ELVeS has FDA clearance ...
... QuadraLase™ is a unique ... cap that may be rotated ... positions: like having four fibers ... be used for vaporization and ...
... the first truly lateral, all quartz fiber. ... (NA) compression technology for Total Internal Reflection ... The resulting output is virtually indistinguishable from ... transmission efficiency in a round spot of ...
Medicine Products: