Navigation Links
PD-like sleep and motor problems observed in α-synuclein mutant mice
Date:6/7/2013

Amsterdam, NL, 7 June 2013 The presence of Lewy bodies in nerve cells, formed by intracellular deposits of the protein α-synuclein, is a characteristic pathologic feature of Parkinson's Disease (PD). In the quest for an animal model of PD that mimics motor and non-motor symptoms of human PD, scientists have developed strains of mice that overexpress α-synuclein. By studying a strain of mice bred to overexpress α-synuclein via the Thy-1 promoter, scientists have found these mice develop many of the age-related progressive motor symptoms of PD and demonstrate changes in sleep and anxiety. Their results are published in the latest issue of Journal of Parkinson's Disease.

PD is the second most common neurodegenerative disorder in the United States, affecting approximately one million Americans and five million people worldwide. Its prevalence is projected to double by 2030. The most obvious symptoms are movement-related, such as involuntary shaking and muscle stiffness; non-motor symptoms, such as increases in anxiety and sleep disturbances, can appear prior to the onset of motor symptoms. Although the drug levodopa can relieve some symptoms, there is no cure intensifying the pressure to find an animal model that can help clarify the pathological processes underlying human PD and find new medications to treat the pathology and/or relieve symptoms.

Investigators at the National Institute on Aging compared wild type mice with specially bred mice that were transgenic for the A53T mutation of the human α-synuclein (SNCA) gene under the control of a human thymus cell antigen 1, theta (THY-1) promoter. As the mice aged, their motor performance on a rotarod test (which measures how long the mouse can remain on a rotating rod) became impaired and the length of their strides were significantly shorter than the wild type control mice.

The study also found that SNCA mice displayed fragmented nighttime activity patterns compared to wild type controls and appeared to have a reduced overall sleep time. "Despite the prevalence of abnormal sleep patterns in PD, very few studies to date have outlined sleep disturbances in animal models of PD," says Sarah M. Rothman, PhD, a researcher with the National Institute on Aging, in Baltimore, MD.

Many PD patients typically show an increase in anxiety and depression, and in this respect the SNCA mouse model did not replicate the human condition. SNCA mice displayed an early and significant decrease in anxiety-like behavior that persisted throughout their lifespan, as shown by both open field and elevated plus maze tests (in which mice have the choice of spending time in open or closed arms of a maze). Other rodent models that utilize changes in expression of α-synuclein have also reported lower anxiety levels. The authors suggest that higher levels of serotonin found in the hypothalamus of the SNCA mice may be associated with the reduced anxiety observed.

The authors say it is important to remember that the SNCA "model utilizes the presence of a mutation that only occurs very rarely in PD. While all PD patients display α-synuclein pathology, they do not all express the mutated form of the protein," says Dr. Rothman.


'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
2. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
3. Depressed moms behavior may play role in infants sleep problems
4. Depressed Moms May Hinder Babies Sleep
5. Poor Sleep Heightens Ringing Ear Disease Symptoms: Study
6. Adjusting Your Attitude About Chronic Pain May Help You Sleep
7. Excessive sleepiness may be cause of learning, attention and school problems
8. Study: Kids Who Sleep in Parents Bed Less Likely to Be Overweight
9. Sleepwalking in Adults More Common Than Thought
10. Pediatric epilepsy impacts sleep for the child and parents
11. Parents Often Lose Sleep Over Childs Epilepsy, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Old School Labs™, makers of the ... as a new Brand Ambassador. Theophane, who trained with Floyd Mayweather, made his professional ... He has racked up an impressive number of wins in contests in Britain, Germany ...
(Date:3/22/2017)... ... March 22, 2017 , ... Influence ... its digital marketing solutions have enabled Children’s Hospital of The King’s Daughters (CHKD) ... , Recognizing the value of a digital marketing approach, the 206-bed pediatric teaching ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... a research collaboration to translate advances in basic neuroscience at the BMRI labs ... beyond. The collaboration seeks to improve movement, vision, and cognition impaired by stroke, traumatic ...
(Date:3/22/2017)... NY (PRWEB) , ... March 22, 2017 , ... The ... communities in the greater Nassau County region, is embarking on a combined charity effort ... cancer. , For the last 25 years, the Great Neck Breast Cancer Coalition ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... Chris Humphrey ... to families and business professionals throughout the coastal plains region, is initiating a charity ... overcome cancer. , Dillyn was first diagnosed with leukemia on a Friday evening in ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... Sweden , March 22, 2017 TFS ... and Mr. Ed Tumaian , two global executive positions ... will be joining the Operational Leadership Team and will report to ... ... comes to TFS with 10 years of medical and scientific ...
(Date:3/22/2017)... N.Y. , March 22, 2017  As the ... Leukemia & Lymphoma Society (LLS) has played a role ... patients, some of which are even helping patients with ... due to LLS,s significant investment in cutting-edge research – ... milestone continues to grow with the record-breaking sum of ...
(Date:3/22/2017)... -- NetworkNewsWire Editorial Coverage  ... Deciphering marijuana policy under the ... House officials. Federal laws are at odds with a number ... use, and businesses like SinglePoint, Inc. (OTC: SING) ( SING ... Inc. (OTC: MJNA), Cannabis Science, Inc. (OTC: CBIS) and ChineseInvestors.com, ...
Breaking Medicine Technology: