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PCa markers improve predictive performance of existing clinical variables
Date:3/18/2013

and genetic score) using a logistic regression model. Area under the receiver operating characteristic curve (AUC) was used to assess the ability of clinical variables and the genetic score to predict for positive prostate biopsy. Detection rate of PCa was also used to assess performance of predictors.

The results of the study revealed that the PCa detection rate was 45% overall in this biopsy cohort, and was 29% and 79%, respectively for patients with total PSA levels =20 ng/ml (~1/3 of patients). Age, total PSA levels, and genetic score were independent predictors of biopsy outcomes, P = 0.002, 7.18 x 10-9, and 0.01, respectively.

The AUC for discriminating biopsy outcomes was 0.65, 0.79, and 0.66, respectively for age, total PSA, and genetic score. When genetic score was added to the model with age and total PSA, the AUC for discriminating biopsy outcomes increased from 0.82 to 0.86. The difference in AUC was statistically significant, P < 0.05. For patients with total PSA levels 1.5.


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Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Page: 1 2

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