Navigation Links
PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach
Date:7/28/2009

LEIDEN, The Netherlands, July 29, 2009 The US-based PATH Malaria Vaccine Initiative (MVI), the United States Agency for International Development (USAID) Malaria Vaccine Development Program (MVDP), and Dutch biopharmaceutical company Crucell N.V. today announced a collaboration to accelerate development of a promising type of malaria vaccine. Through funding from the USAID MVDP, the partners will conduct studies to determine the effectiveness of Crucell's novel prime-boost vaccine approach against the malaria parasite, Plasmodium falciparum. This approach uses Crucell's proprietary recombinant adenoviruses (a type of virus associated with the common cold and other mild respiratory infections) to deliver a malaria antigen to the immune system.

Dr. Jaap Goudsmit, Chief Scientific Officer at Crucell, commented, "This agreement is a strong validation of Crucell's malaria vaccine approach. We are excited to have MVI as our partner and to have the support of USAID. The fact that MVI is backing our program testifies to the importance of our efforts to further progress the development of Crucell's malaria vaccine."

For MVI, this partnership adds to its existing portfolio a vaccine approach with the potential to elicit a more comprehensive immune response than has been seen to date from the circumsporozoite protein (CSP), the only antigen that has proven to be protective against malaria in controlled challenge studies and field studies. Using Crucell's AdVac technology with two different vectorsthe adenovirus serotypes Ad35 and Ad26 as delivery mechanisms, this approach seeks to elicit a protective immune response obtained from delivering the CSP. The safety, immunogenicity and efficacy data from these studies will further advance the research forward development of a safe and highly efficacious malaria vaccine.

"Adenoviruses are one of the most potent vaccine delivery systems tested to date in humans. We are excited about the potential of Crucell's adenovirus-based program and the novel Ad35/Ad26 approach. The prime-boost regimen may be a critical next step in malaria vaccine development and, if successful, could move us toward our goal of having an 80 percent efficacious vaccine in use by 2025," said MVI Director, Dr. Christian Loucq.

Crucell is developing a recombinant malaria vaccine, Ad35-CS, based on the company's AdVac technology and PER.C6 manufacturing platform. The vaccine candidate is made by inserting the CSP gene from the P. falciparum malaria parasite into adenoviral vectors, which act as a 'vehicle' for vaccination delivery. This prime vaccine candidate is currently being tested in a Phase 1 study in partnership with the National Institute of Allergy and Infectious Diseases. This new collaboration will make it possible to clinically develop the Ad26 boost component of the vaccine and allow Crucell to further strengthen and expedite its malaria development program.

Carter Diggs at the USAID MVDP said, "We are pleased to support this adenovirus approach, which could play a vital role in malaria vaccine development."


'/>"/>

Contact: Preeti Singh
psingh@burnesscommunications.com
301-652-1558 x5722
Burness Communications
Source:Eurekalert

Related medicine news :

1. Counterfeit antimalarial drug discovered in Ghana
2. New global subsidy for malaria medicines must ensure quality of care
3. Miles To End Malaria Program Gets an Extra Burst of Speed From American Le Mans Series Founder Don Panoz
4. Global Fund Increases AIDS, Tuberculosis and Malaria Prevention and Treatment Measures by 30-50% Over One Year
5. Marathon and Partners Announce Dramatic Results of Malaria Control Project on Bioko Island in Equatorial Guinea
6. Deploying the Power of Music to Save Lives West Africas Most Beloved Singer Raises His Voice to End Malaria
7. House Subcommittee Markup Leaves Global Fund to Fight AIDS, TB, and Malaria in Crisis
8. Washington, DC Community Leaders Commit to Send 10,000 Anti-Malarial Bed Nets to Refugees in Africa
9. Prospero Group (PRPG) and Fincor (FINC) Made a Share Transfer and Enter the Market with ACTRx a New Malaria and Dengue Fever Treatment
10. Simple blood test proves powerful ally in the fight against malaria
11. UN Foundation to Help Protect More than a Million Refugees from Malaria in Africa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... Raton, FL (PRWEB) , ... January 20, 2017 , ... ... development, announced it attended the January ECRM trade show to continue the marketing and ... advanced vitamin C supplement, known for providing 400 percent better absorption than traditional vitamin ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... International Protein, ... nutritional and bodybuilding supplements, announced it attended the January ECRM trade show in Hilton ... and nutritional scientist who was determined to create a line of products that would ...
(Date:1/20/2017)... ... ... Magdalene: Grace is Greater than Sin”: a unique and memorable piece of literature ... Grace is Greater than Sin” is the creation of published author, Brenda Roberts, a ... had little knowledge of the female characters portrayed in the Holy Bible. , ...
(Date:1/20/2017)... NC (PRWEB) , ... January 20, 2017 , ... ... vPEP ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in a ... by Doug Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive Expiratory ...
(Date:1/20/2017)... ... 20, 2017 , ... “The Land of More and More”: a brilliant ... hunger, and shares the simple and achievable answer. “The Land of More and More” ... Fairview Missionary Church in Angola, Indiana where he works with the children’s ministry department. ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... , January 20, 2017 Stock-Callers.com today ... SGYP ), Novo Nordisk A/S (NYSE: ... and Pernix Therapeutics Holdings Inc. (NASDAQ: PTX ). ... Thursday, January 19 th , 2017, finishing near its session ... Index dropped over 0.7%, while shares of health care companies ...
(Date:1/20/2017)... 20, 2017  Palladian Health, a leading provider ... launch of an opioid management program which assists ... and helps stem the growing tide of dependence ... treat chronic non-cancer pain (back pain, neck pain, ... lack of evidence regarding long-term effectiveness. ...
(Date:1/20/2017)... 2017 Entscheidung fällt ... Die internationale humanitäre Stadt soll um knapp ... Seine Hoheit Scheich Muhammad bin ... Herrscher von Dubai , hat den ... (International Humanitarian City IHC) zu verdreifachen, um den Betrieb ...
Breaking Medicine Technology: