Navigation Links
PAP therapy improves neurobehavioral outcomes in children with OSA
Date:2/9/2012

Treatment of childhood obstructive sleep apnea syndrome (OSAS) with positive airway pressure (PAP) therapy improves a number of important neurobehavioral outcomes, according to a new study from the The Children's Hospital of Philadelphia.

"In our study of 52 children and adolescents with OSAS, we observed significant improvements in neurobehavioral function after three months of PAP therapy," said lead author Carole L. Marcus, professor of pediatrics at the Children's Hospital of Philadelphia. "These improvements were seen despite suboptimal adherence with treatment and were observed in a heterogeneous group of children, many with underlying medical conditions and/or developmental delays."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the prospective study, 52 children (mean age 12 4 years) with OSAS, 10 of whom had significant developmental delays, underwent neurobehavioral assessments of sleepiness, behavioral problems, attention and quality of life at baseline and after three months of PAP treatment. Adherence with PAP treatment varied widely, with an average use of 170+145 minutes per night.

PAP treatment was associated with significant improvements in attention deficits, behavior, sleepiness and caregiver- and child-reported quality of life. Improvements in sleepiness scores, but not in other outcomes, were significantly correlated with adherence. Similar improvements in behavioral scores were seen in the subset of children with developmental delays. Among subjects younger than seven (mean age 4.5 1.7 years), significant improvements were seen in sleepiness and OSAS-specific quality of life.

"OSAS in children is known to be associated with behavioral disturbances and learning deficits, but the effects of PAP therapy on these deficits have not been studied," said Dr. Marcus. "Our study is the first to demonstrate that PAP therapy results in significant improvements in a range of neurobehavioral domains in these patients, including those with developmental delays."

The study had several limitations, including the lack of a placebo group, the use of reports from subjects and caregivers only, and the lack of blinding.

"The improvements we observed in daytime sleepiness, attention, internalizing behaviors and quality of life occurred despite a mean use of PAP of only three hours a night," said Dr. Marcus. "This suggests that PAP use should be encouraged in children with OSAS, even in those with suboptimal adherence, as it can lead to improvements in function that can in turn affect family, social and school function."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Nanotube therapy takes aim at breast cancer stem cells
2. Combination drug therapy urged to battle lung cancer
3. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
4. Stem Cell Therapy Shows Promise for Stroke, Studies Say
5. ACCF/AATS/SCAI/STS release consensus document to help guide use of minimally invasive heart therapy
6. New target for cancer therapy identified, preclinical study shows
7. Research finds newer radiation therapy technology improves patients quality of life
8. Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients
9. Brachytherapy reduced death rates in high-risk prostate cancer patients, study finds
10. Rowley to receive Japan Prize for her role in the development of targeted cancer therapy
11. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... Levels of a protein in the blood associated ... appearing online in the journal Radiology. , Heart disease and brain disease exact a ... the rapidly aging population. Damage to both organs often occurs at a subclinical stage, ...
(Date:12/7/2016)... ... December 07, 2016 , ... ODU, a worldwide ... US market its advanced highly customizable contact technology solutions. , ODU Single Contact ... technologies are ideal for a wide range of applications that require customization from ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... and financial planning services to families and business owners in the greater Dallas ... behalf of the Dallas Fallen Officer Foundation. , Established in 2009 by active ...
(Date:12/7/2016)... ... December 07, 2016 , ... A. Kevin Spann Insurance, ... families throughout the Five Boroughs, is launching a charity drive to raise funds that ... the traditions and spirit of marines and Navy FMF Corpsmen. Working closely with the ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Honolulu cosmetic ... redesigned website, which launched October 17, 2016, features comprehensive information regarding a wide ... layout. Visitors and patients can discover the latest clinical dermatology treatments for medical ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Inc. (NASDAQ: IONS ), the leader in antisense therapeutics, ... BMO Capital Markets Prescriptions for Success Healthcare Conference on Wednesday, December ... A live webcast of the presentation will be available on the ... be available within 48 hours and will be archived for a ... , , ...
(Date:12/7/2016)... Inc. (NYSE: LCI ) today announced that the company ... Healthcare Conference on December 14, 2016 at 9:20 a.m. (ET) at ... . In addition, the company will host one-on-one meetings ... Annual Boston Healthcare Conference taking place on December 13, 2016 at ... , ...
(Date:12/6/2016)... 2016  Alopexx Oncology, LLC announced data from a ... protein (immunocytokine) composed of interleukin-2 and a CD20-targeting monoclonal ... B cells as Rituxan and maintains the activities of ... involved in tumor targeting, engagement of the immune system, ... of the study (abstract #95954) were presented at the ...
Breaking Medicine Technology: