Navigation Links
PAP therapy improves neurobehavioral outcomes in children with OSA
Date:2/9/2012

Treatment of childhood obstructive sleep apnea syndrome (OSAS) with positive airway pressure (PAP) therapy improves a number of important neurobehavioral outcomes, according to a new study from the The Children's Hospital of Philadelphia.

"In our study of 52 children and adolescents with OSAS, we observed significant improvements in neurobehavioral function after three months of PAP therapy," said lead author Carole L. Marcus, professor of pediatrics at the Children's Hospital of Philadelphia. "These improvements were seen despite suboptimal adherence with treatment and were observed in a heterogeneous group of children, many with underlying medical conditions and/or developmental delays."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the prospective study, 52 children (mean age 12 4 years) with OSAS, 10 of whom had significant developmental delays, underwent neurobehavioral assessments of sleepiness, behavioral problems, attention and quality of life at baseline and after three months of PAP treatment. Adherence with PAP treatment varied widely, with an average use of 170+145 minutes per night.

PAP treatment was associated with significant improvements in attention deficits, behavior, sleepiness and caregiver- and child-reported quality of life. Improvements in sleepiness scores, but not in other outcomes, were significantly correlated with adherence. Similar improvements in behavioral scores were seen in the subset of children with developmental delays. Among subjects younger than seven (mean age 4.5 1.7 years), significant improvements were seen in sleepiness and OSAS-specific quality of life.

"OSAS in children is known to be associated with behavioral disturbances and learning deficits, but the effects of PAP therapy on these deficits have not been studied," said Dr. Marcus. "Our study is the first to demonstrate that PAP therapy results in significant improvements in a range of neurobehavioral domains in these patients, including those with developmental delays."

The study had several limitations, including the lack of a placebo group, the use of reports from subjects and caregivers only, and the lack of blinding.

"The improvements we observed in daytime sleepiness, attention, internalizing behaviors and quality of life occurred despite a mean use of PAP of only three hours a night," said Dr. Marcus. "This suggests that PAP use should be encouraged in children with OSAS, even in those with suboptimal adherence, as it can lead to improvements in function that can in turn affect family, social and school function."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Nanotube therapy takes aim at breast cancer stem cells
2. Combination drug therapy urged to battle lung cancer
3. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
4. Stem Cell Therapy Shows Promise for Stroke, Studies Say
5. ACCF/AATS/SCAI/STS release consensus document to help guide use of minimally invasive heart therapy
6. New target for cancer therapy identified, preclinical study shows
7. Research finds newer radiation therapy technology improves patients quality of life
8. Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients
9. Brachytherapy reduced death rates in high-risk prostate cancer patients, study finds
10. Rowley to receive Japan Prize for her role in the development of targeted cancer therapy
11. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... Wausau, WI (PRWEB) , ... February 27, 2017 , ... ... Young Investigator Award. Dr. Chen will receive his award during the Plenary Session at ... Inc. (ASLMS), to be held in San Diego, California April 5-9, 2017. , ...
(Date:2/27/2017)... ... 27, 2017 , ... Robert E. Burke, MD, PhD, had a successful career ... and life experiences could have led him down a much different path. , In ... Parenting, Perseverance and Pediatrics,” Dr. Burke shares a personal account of the tribulations he ...
(Date:2/27/2017)... ... February 27, 2017 , ... The threat of nuclear warfare ... for a company involved in the underground testing of nuclear weapons. Years later, when ... Expendable Workers of the Cold War Nuclear Testing,” Clayton exposes the critical decisions made ...
(Date:2/27/2017)... ... 27, 2017 , ... This webinar , sponsored by ... tool to characterize particle size distributions in the field of geoscience and soil ... scientific findings. It describes methods of optimized and standardized sample collection, preparation and ...
(Date:2/27/2017)... ... February 27, 2017 , ... ... mark last week. In addition, Discount Power's RCE (Residential Customer Equivalent) count exceeds ... March 2014. The company had 800 customers and 2,250 RCEs at the time ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... The global  pulse oximeters market  is expected to reach USD 2.8 ... The pulse oximeters market is anticipated to witness significant growth during the forecast ... as chronic obstructive pulmonary disease (COPD), sleep apnea, cardiac arrhythmia, and ischemic conditions. ... ... Grand View Research Logo ...
(Date:2/28/2017)... This report provides all the information you require to ... since 2010. Download the full report: ... Alliance since 2010 report provides an in-depth insight into ... life sciences companies. On demand company reports ... most up to date deal and company data. ...
(Date:2/28/2017)... , Feb 28, 2017 ... Research and Markets ... 2025" report to their offering. The global ... The orthobiologics market is predominantly driven by ... technological innovations in biomaterials, used in the production of orthobiologics are ...
Breaking Medicine Technology: