Navigation Links
PAP therapy improves neurobehavioral outcomes in children with OSA
Date:2/9/2012

Treatment of childhood obstructive sleep apnea syndrome (OSAS) with positive airway pressure (PAP) therapy improves a number of important neurobehavioral outcomes, according to a new study from the The Children's Hospital of Philadelphia.

"In our study of 52 children and adolescents with OSAS, we observed significant improvements in neurobehavioral function after three months of PAP therapy," said lead author Carole L. Marcus, professor of pediatrics at the Children's Hospital of Philadelphia. "These improvements were seen despite suboptimal adherence with treatment and were observed in a heterogeneous group of children, many with underlying medical conditions and/or developmental delays."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the prospective study, 52 children (mean age 12 4 years) with OSAS, 10 of whom had significant developmental delays, underwent neurobehavioral assessments of sleepiness, behavioral problems, attention and quality of life at baseline and after three months of PAP treatment. Adherence with PAP treatment varied widely, with an average use of 170+145 minutes per night.

PAP treatment was associated with significant improvements in attention deficits, behavior, sleepiness and caregiver- and child-reported quality of life. Improvements in sleepiness scores, but not in other outcomes, were significantly correlated with adherence. Similar improvements in behavioral scores were seen in the subset of children with developmental delays. Among subjects younger than seven (mean age 4.5 1.7 years), significant improvements were seen in sleepiness and OSAS-specific quality of life.

"OSAS in children is known to be associated with behavioral disturbances and learning deficits, but the effects of PAP therapy on these deficits have not been studied," said Dr. Marcus. "Our study is the first to demonstrate that PAP therapy results in significant improvements in a range of neurobehavioral domains in these patients, including those with developmental delays."

The study had several limitations, including the lack of a placebo group, the use of reports from subjects and caregivers only, and the lack of blinding.

"The improvements we observed in daytime sleepiness, attention, internalizing behaviors and quality of life occurred despite a mean use of PAP of only three hours a night," said Dr. Marcus. "This suggests that PAP use should be encouraged in children with OSAS, even in those with suboptimal adherence, as it can lead to improvements in function that can in turn affect family, social and school function."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Nanotube therapy takes aim at breast cancer stem cells
2. Combination drug therapy urged to battle lung cancer
3. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
4. Stem Cell Therapy Shows Promise for Stroke, Studies Say
5. ACCF/AATS/SCAI/STS release consensus document to help guide use of minimally invasive heart therapy
6. New target for cancer therapy identified, preclinical study shows
7. Research finds newer radiation therapy technology improves patients quality of life
8. Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients
9. Brachytherapy reduced death rates in high-risk prostate cancer patients, study finds
10. Rowley to receive Japan Prize for her role in the development of targeted cancer therapy
11. Scientists report first step in strategy for cell replacement therapy in Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. Ogunleye ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Ogunleye ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
(Date:6/23/2016)... announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... ... ... Astellas is a pharmaceutical ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
Breaking Medicine Technology: