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Ozone shuts down early immune response in lungs and body
Date:9/30/2007

DURHAM, N.C. As policy makers debate what levels of ozone in the air are safe for humans to breathe, studies in mice are revealing that the inhaled pollutant impairs the bodys first line of defense, making it more susceptible to subsequent foreign invaders, such as bacteria.

While it has long been known that exposure to ozone, a major component of urban air pollution, is associated with increased cardiovascular and pulmonary hospitalizations and deaths, the actual mechanisms involved remain unclear. New studies by Duke University Medical Center pulmonary researchers on the effects of ozone on the innate immune system, the bodys tripwire for foreign invaders, may provide part of the answer.

The Duke-led team found that ozone exposure in mice at levels approximating unhealthy levels for humans appears to enhance lung injury in response to bacterial toxins, but more importantly, it also appears to enhance programmed cell death in critical innate immune system cells that gobble up foreign invaders, keeping the airways clear.

Small amounts of inhaled foreign material can be relatively harmless, since they stimulate an appropriate innate immune response that protects the lungs, said John Hollingsworth, M.D., pulmonologist and lead author of study whose results appear Oct. 1 in the Journal of Immunology. However, it appears that ozone causes the innate immune system to overreact, killing key immune system cells, and possibly making the lung more susceptible to subsequent invaders, such as bacteria.

The innate immune system is the most primitive aspect of the bodys defenses. Its cells react indiscriminately to any invader. One of the key cells in the innate immune system is known as a macrophage, Greek for big eater.

For their experiments, the researchers had mice breathe either room air or air with levels of ozone meant to mirror what an exercising human would experience on a high, or unhealthy, ozone level day. After ex
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Contact: Richard Merritt
Merri006@mc.duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

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