Navigation Links
Oxygen levels in tumors affect response to treatment
Date:11/7/2013

The genetic make-up of a patient's tumour could be used to personalise their treatment, and help to decide whether they would benefit from receiving additional drugs as part of their radiotherapy programme, according to a recent study involving scientists from the Manchester Cancer Research Centre.

Tumours with lower levels of oxygen known as hypoxia often respond less well to radiation therapy. There are several agents that can be given to patients before radiotherapy to reduce hypoxia, but these are not given as standard. Being able to measure how well-oxygenated an individual's tumour is would give doctors a valuable way of identifying which patients might benefit from treatment with hypoxia reducing agents before radiotherapy.

Hypoxia has previously been investigated by looking at the expression of certain genes, and Manchester researchers have come up with a genetic profile for tumours that should indicate the overall level of oxygenation.

Researchers at The University of Manchester, part of the Manchester Cancer Research Centre, carried out the study in patients diagnosed with cancer of the bladder and larynx. These patients subsequently underwent either standard radiotherapy or radiotherapy with the addition of two agents which in combination are known to increase oxygenation: nicotinamide and carbogen.

The team tested patients' tumour samples for 26 genes in order to classify them as more or less hypoxic, and then analysed whether this hypoxia score related to the results of treatment.

"Our goal is to find ways of predicting how patients will respond to different treatments. Future cancer treatments will be personalised so that patients get the best therapy for their tumour." said Professor Catharine West, who led the research. "Personalising therapy will not only increase the number of people surviving cancer but also decrease side-effects, as patients would be spared from having treatments that are unlikely to work in their tumour."

A paper recently published in Clinical Cancer Research describes how the group found that for laryngeal tumours, those classed as more hypoxic saw a significant benefit from receiving additional agents as well as radiation therapy. However, in bladder cancer, patients with more hypoxic tumours did not benefit from adding extra agents.

Professor West added: "We will now test how the hypoxia score works in the clinic in a trial starting in December in patients with head and neck cancer. I have studied ways of measuring hypoxia in tumours for many years so this is a very exciting finding that could help us optimise how we use radiotherapy to get the best outcome for patients."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Oxygen Concentrators: Market Shares, Strategies, and Forecasts, Worldwide, 2013 to 2018
2. InventHelp® Client Develops Oxygen-Tank Accessory (JMC-1162)
3. InventHelp® Client Invention Allows For Safer Use of Oxygen Hoses (CLC-4778)
4. Considering Transplant and on Oxygen, Singer-Songwriter with Rare Lung Disease Returns to Stage Nov. 7, Pulmonary Hypertension Association Announces
5. Oxygen and Heart Rate Baby Monitor Meets $100k Crowdfunding Goal; Next Goal: Saving Infant Lives
6. Device Designed by InventHelp® Client Makes Oxygen-Tubing Use Easier and Safer (CCT-721)
7. Global Portable Oxygen Concentrators Market are Anticipated to Reach $1.9 billion by 2019 - Industry Shares, Strategies, and Forecasts, Worldwide Research Report
8. Market for Oxygen & Portable Oxygen Concentrator (POC) 2019 Analysis & Forecast in New Research Report at ReportsnReports.com
9. InventHelp® Client Patents “IV-Oxygen Walker” – Medical Invention Could Improve Conventional Rolling Walker
10. When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs
11. Reduced Oxygen Levels Could Double Neural Stem Cells’ Chance of Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  In a startling report released today, National Safety ... lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... how states are tackling the worst drug crisis in recorded U.S. ... Kentucky , New Mexico , ... Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
Breaking Medicine Technology: