Navigation Links
Oxygen levels in tumors affect response to treatment

The genetic make-up of a patient's tumour could be used to personalise their treatment, and help to decide whether they would benefit from receiving additional drugs as part of their radiotherapy programme, according to a recent study involving scientists from the Manchester Cancer Research Centre.

Tumours with lower levels of oxygen known as hypoxia often respond less well to radiation therapy. There are several agents that can be given to patients before radiotherapy to reduce hypoxia, but these are not given as standard. Being able to measure how well-oxygenated an individual's tumour is would give doctors a valuable way of identifying which patients might benefit from treatment with hypoxia reducing agents before radiotherapy.

Hypoxia has previously been investigated by looking at the expression of certain genes, and Manchester researchers have come up with a genetic profile for tumours that should indicate the overall level of oxygenation.

Researchers at The University of Manchester, part of the Manchester Cancer Research Centre, carried out the study in patients diagnosed with cancer of the bladder and larynx. These patients subsequently underwent either standard radiotherapy or radiotherapy with the addition of two agents which in combination are known to increase oxygenation: nicotinamide and carbogen.

The team tested patients' tumour samples for 26 genes in order to classify them as more or less hypoxic, and then analysed whether this hypoxia score related to the results of treatment.

"Our goal is to find ways of predicting how patients will respond to different treatments. Future cancer treatments will be personalised so that patients get the best therapy for their tumour." said Professor Catharine West, who led the research. "Personalising therapy will not only increase the number of people surviving cancer but also decrease side-effects, as patients would be spared from having treatments that are unlikely to work in their tumour."

A paper recently published in Clinical Cancer Research describes how the group found that for laryngeal tumours, those classed as more hypoxic saw a significant benefit from receiving additional agents as well as radiation therapy. However, in bladder cancer, patients with more hypoxic tumours did not benefit from adding extra agents.

Professor West added: "We will now test how the hypoxia score works in the clinic in a trial starting in December in patients with head and neck cancer. I have studied ways of measuring hypoxia in tumours for many years so this is a very exciting finding that could help us optimise how we use radiotherapy to get the best outcome for patients."


Contact: Alison Barbuti
University of Manchester

Related medicine news :

1. Oxygen Concentrators: Market Shares, Strategies, and Forecasts, Worldwide, 2013 to 2018
2. InventHelp® Client Develops Oxygen-Tank Accessory (JMC-1162)
3. InventHelp® Client Invention Allows For Safer Use of Oxygen Hoses (CLC-4778)
4. Considering Transplant and on Oxygen, Singer-Songwriter with Rare Lung Disease Returns to Stage Nov. 7, Pulmonary Hypertension Association Announces
5. Oxygen and Heart Rate Baby Monitor Meets $100k Crowdfunding Goal; Next Goal: Saving Infant Lives
6. Device Designed by InventHelp® Client Makes Oxygen-Tubing Use Easier and Safer (CCT-721)
7. Global Portable Oxygen Concentrators Market are Anticipated to Reach $1.9 billion by 2019 - Industry Shares, Strategies, and Forecasts, Worldwide Research Report
8. Market for Oxygen & Portable Oxygen Concentrator (POC) 2019 Analysis & Forecast in New Research Report at
9. InventHelp® Client Patents “IV-Oxygen Walker” – Medical Invention Could Improve Conventional Rolling Walker
10. When oxygen is short, EGFR prevents maturation of cancer-fighting miRNAs
11. Reduced Oxygen Levels Could Double Neural Stem Cells’ Chance of Survival
Post Your Comments:
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
Breaking Medicine Technology: