Navigation Links
Oxygen in tumors predicts prostate cancer recurrence
Date:3/31/2012

TORONTO -- Low oxygen levels in tumors can be used to predict cancer recurrence in men with intermediate-risk prostate cancer even before they receive radiation therapy.

The clinical research, led by radiation oncologists at the Princess Margaret Hospital (PMH) Cancer Program, University Health Network (UHN) is published online today in Clinical Cancer Research, a journal of the American Association for Cancer Research (doi: 10.1158/1078-0432.CCR-11-2711).

"We've not only shown that men do worse if they have low oxygen levels (hypoxia) in their prostate cancer, but that they also do worse over a shorter period of time," says Dr. Michael Milosevic, radiation oncologist in the PMH Cancer Program, UHN. "These patients seem to develop cancer recurrence within only a few years of completing treatment."

"This information could change the way prostate cancer is treated and goes a long way to ensuring that all patients receive the right treatment from the outset based on their individual tumour," says Dr. Milosevic, who is also a professor of radiation oncology at the University of Toronto. "At the heart of it, this is what personalized medicine is all about."

Prostate cancer is commonly treated with surgery or radiation therapy, and yet cancer recurs or spreads in about 25% of treated men. The discovery of indicators, such as low oxygen in tumours, enables doctors to better select the most appropriate and effective treatments for each patient even before radiation therapy is delivered.

Dr. Milosevic and colleagues measured oxygen levels in 247 men with localized prostate cancer prior to radiation therapy and followed them for a median of 6.6 years. Low oxygen in the tumors predicted early relapse after radiation treatment. It was also the only identified factor that predicted local recurrence during follow-up.

"We believe that a tumour's genetic signature will be another promising predictor of recurrence," says Dr. Robert Bristow, radiation oncologist in the PMH Cancer Program, UHN, and professor in the departments of radiation oncology and medical biophysics at the University of Toronto. "Combined, these indicators may signal that the cancer has spread at a previously-undetectable level."

Dr. Milosevic and colleagues hope that identifying the factors that influence prostate cancer behavior will lead to the exploration of new drugs to target hypoxia in tumors. The findings may also accelerate the development of new treatment strategies informing physicians when complementary treatment may be more effective. .

"Knowing what works for which patient will make treatment more effective and improve outcomes for patients," says Dr. Milosevic.


'/>"/>
Contact: Geoff Koehler
geoff.koehler@uhn.ca
416-340-4011
University Health Network
Source:Eurekalert

Related medicine news :

1. K-State professor finds link between low oxygen levels in body and cancer-aiding protein
2. Low blood oxygen may lead to heart defects in children with sickle cell disease
3. For Preemies, Better Use of Oxygen Improves Survival
4. Higher oxygen levels improve preterm survival, increase risk for eye condition
5. Study challenges value of oxygen therapy in end-of-life care
6. Powerful free radical causes lung damage from oxygen therapy
7. Neural stem cells maintain high levels of reactive oxygen species, UCLA study finds
8. Higher Oxygen Levels Improve Preemie Survival: Study
9. Penguins continue diving long after muscles run out of oxygen
10. More oxygen in eyes of African-Americans may help explain glaucoma risk
11. Oxygenating system associated with lower risk of death for H1N1 patients with respiratory failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... , ... The American public tends to feel uncomfortable about drinking recycled waste ... or well water. The recent experience with lead contaminated water in Flint, Michigan, according ... toward increasing public acceptance of recycled waste water as drinking water. , The ...
(Date:2/5/2016)... SARASOTA, Fla., (PRWEB) , ... February 05, 2016 , ... ... appetizing recipes just in time for this weekend’s Big Game. Take the stress out ... ingredients that will keep your guests happy at every stage of the game. , ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Justin Scott and ... 2nd Annual No Cost Dental Day to individuals in need. The event is scheduled ... this No Cost Dental Day is to provide dental care to community members in ...
(Date:2/5/2016)... ... February 05, 2016 , ... Colorize is a web ... zone to the next using Colorize's dynamic moving camera. Colorize is perfect for personal ... a 3D slideshow environment with 1 to 5 focus points per scene, stage floor ...
(Date:2/5/2016)... ... , ... California Mobile Kitchens , a company that ... mobile kitchen model, featuring customizable stainless steel interiors and a new, 26-foot unit. ... anywhere in the U.S. Many of their units can be seen at sporting ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Global Immunology Market to 2022 - ... market growth Summary Immune-mediated inflammatory diseases ... that affect 5–7% of western populations. Although they ... and key patient demographics, they are pathophysiologically linked, ... an inappropriate immune response. Generally, disease-modifying anti-rheumatic drugs, ...
(Date:2/4/2016)... Feb. 4, 2016 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year.  Reported sales decreased 3% ... quarter. , Net earnings per diluted share as ... prior- year period.  Adjusted EPS was $4.65, an increase ...
(Date:2/4/2016)... 4, 2016  AMRI (NASDAQ:  AMRI) today announced that ... and President of Pfizer Global Supply, has been elected to ... 2016. In addition, the Company announced that Mr. Gabe ... since 2010, has retired from the AMRI Board of Directors ... other business ventures.  William S. Marth , ...
Breaking Medicine Technology: