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Oxygen Treatment May Improve the Odds for Extreme Preemies
Date:12/27/2012

WEDNESDAY, Dec. 26 (HealthDay News) -- Treating very premature infants with high oxygen levels to improve their ability to breathe appears to boost their chances of surviving into toddlerhood, a new U.S. National Institutes of Health study found.

The report is a follow-up to a 2010 study that found higher immediate survival rates among babies who were born between 24 and 27 weeks' gestation who were given high oxygen treatment. That study found that when given highly saturated oxygen (from 91 percent to 95 percent), premature infants fared better than those given relatively low saturated oxygen (from 85 percent to 89 percent).

But concern about long-term survival, as well as a related risk for severe vision impairment, led the research team to continue tracking the infants until they reached the age of 18 months to 22 months after their original due date (the date they would have been born if carried to full term, which is generally considered about 40 weeks' gestation).

Study senior author Dr. Rosemary Higgins, of the pregnancy and perinatology branch of the U.S. National Institute of Child Health and Human Development, said in an institute news release that "higher oxygen targets improve survival and don't appear to threaten survivors' vision in the longer term."

Higgins and her colleagues report the results in the Dec. 27 issue of the New England Journal of Medicine.

To assess the relative benefits of high or low oxygen treatment, the authors focused on toddler survival and developmental status among 1,300 preterm infants who had been born sometime between 2005 and 2009.

The investigators found that 60 percent of all of the preterm infants (regardless of treatment type) showed no signs of either physical or mental impairment as toddlers.

What's more, as a whole, all of the infants seemed to fare comparably well, regardless of treatment approach, when the investigators pool
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