Navigation Links
Oxygen Therapy Slows Type 1 Diabetes in Mice, Study Says
Date:5/11/2012

By Serena Gordon
HealthDay Reporter

FRIDAY, May 11 (HealthDay News) -- Treatment with hyperbaric oxygen therapy helped prevent or slow the progression of type 1 diabetes in mice, according to new research.

It is too early to say if the results might apply to humans, however.

In mice, the treatment caused changes in the immune system's response to newly developing diabetes, and reduced the risk of diabetes between 20 and 40 percent. In the mice that still developed diabetes, the hyperbaric therapy delayed disease progression, the investigators found.

"Hyperbaric oxygen therapy is a relatively non-harmful way of enhancing oxygen delivery to the tissues," said the study's senior author, Dr. Antonello Pileggi, director of the preclinical cell processing and translational models program at the Diabetes Research Institute of the University of Miami Miller School of Medicine.

"We were able to suppress the transfer of the disease (in mice) before the onset of the disease. After diabetes had occurred, the efficacy [of hyperbaric therapy] was much less," said Pileggi. He said that combining hyperbaric therapy with medications might enhance the effectiveness of both treatments.

Results of this study, released online May 7, will be published in the July print issue of Diabetes.

In type 1 diabetes, the immune system mistakenly attacks healthy cells in the pancreas called beta cells. Beta cells produce the hormone insulin that allows your body to metabolize carbohydrates from food, providing fuel for energy. People with type 1 diabetes must replace the lost insulin through multiple daily injections or a pump.

Hyperbaric oxygen therapy -- commonly used to treat scuba divers who develop "the bends" from rising to the surface too quickly -- is delivered in a special pressurized chamber. The pressure inside the chamber is about two and half times greater than the normal pressure in the atmosphere, according to the U.S. National Library of Medicine. This puts more oxygen in your blood. Hyperbaric therapy can also be used to treat bone infections, burns, carbon monoxide poisoning, and wounds that aren't healing well, such as ulcers in people with diabetes. Currently, not very many hospitals offer hyperbaric oxygen therapy.

For the current research, Pileggi and his colleagues used two types of mice. One type develops diabetes spontaneously. It's not exactly the same as type 1 diabetes in humans, but it is very similar, and Pileggi said "it's a good surrogate of type 1." And, the second type doesn't develop diabetes on its own, but the researchers induced diabetes.

In the mice that spontaneously develop diabetes that received hyperbaric therapy, the risk of developing diabetes was reduced by 20 percent. In the mice with induced diabetes, the treatment reduced the risk of diabetes by 40 percent, according to the study. In the mice that still developed diabetes in both groups, treatment with hyperbaric therapy helped delay the onset or progression of the disease.

Pileggi said that the researchers aren't yet clear exactly how hyperbaric therapy prevents or slows the disease, but it's clear the therapy has positive effects on the immune system.

The researchers were also pleasantly surprised to see that the therapy caused a significant increase in creation of new beta cells. "If you can reeducate immune cells and enhance the beta cell mass, that's an ideal situation. But, it's not a silver bullet for diabetes. It could be an adjuvant to other therapies," said Pileggi.

Pileggi said the researchers will test combination treatments but added that it's too soon to guess when such a treatment might be tried in humans.

Another expert said any application to humans is years away.

"This is a novel idea from a good research group. But, while the mouse model is good to study, it doesn't mean that what is affected in mice will be affected in men," said Dr. Joel Zonszein, director of the clinical diabetes center at Montefiore Medical Center in New York City.

Also, it would be difficult to choose who would receive such a therapy, he said, because there isn't a reliable test to determine who will develop type 1 diabetes. There are tests for the antibodies present in type 1, but some people who never develop diabetes have those same antibodies.

"To translate this research to humans would require many more steps," said Zonszein.

More information

Learn more about type 1 diabetes from the American Diabetes Association.

SOURCES: Antonello Pileggi, M.D., Ph.D., director, preclinical cell processing and translational models program, Diabetes Research Institute, University of Miami Miller School of Medicine; Joel Zonszein, M.D., director, clinical diabetes center, Montefiore Medical Center, New York City; May 7, 2012, Diabetes, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Low oxygen levels could drive cancer growth
2. Oxygen in tumors predicts prostate cancer recurrence
3. Cold air chills hearts oxygen supply
4. Extracorporeal membrane oxygenation as a bridge to lung transplantation
5. LSUHSC research shows Rx with hyperbaric oxygen improved TBI and PTSD in vets
6. After Brain Injury, Oxygen Monitoring Vital, Study Finds
7. Gladstone scientists identify gene critical for cell responses to oxygen deprivation
8. Oxygenating Blood of Hospitalized H1N1 Flu Patients Saved Lives: Study
9. Oxygenating system associated with lower risk of death for H1N1 patients with respiratory failure
10. More oxygen in eyes of African-Americans may help explain glaucoma risk
11. Penguins continue diving long after muscles run out of oxygen
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oxygen Therapy Slows Type 1 Diabetes in Mice, Study Says
(Date:2/27/2017)... ... ... Elisa Guajardo Carothers is not your typical author. She went from working as a movie ... writes about God, when she isn’t swimming as a performing mermaid. , Her book isn’t ... Satan),” she offers a comedic look at the dysfunctions of God’s family, before Lucifer was ...
(Date:2/27/2017)... ... February 26, 2017 , ... Miro is the ultimate smart ... video system brings songs, movies, TV shows and much more apps for user exploration. ... sound. An immersive view of 1280 x 720 provides crisp images with remarkable clarity ...
(Date:2/27/2017)... ... 2017 , ... Sunshine Coast Health Centre (SCHC), one of ... https://www.sunshinecoasthealthcentre.ca/ , is proud to announce the addition of a registered massage ... commitment to innovation in drug rehab and alcohol treatment strategies beyond a "punishment" ...
(Date:2/27/2017)... New Jersey (PRWEB) , ... February 27, 2017 , ... ... highest cancer rates, among all types and genders. And the need for advanced services ... by RWJ and its top-rated cancer care program, in collaboration with their non-profit partners ...
(Date:2/26/2017)... (PRWEB) , ... February 26, 2017 , ... ... in 2011 the lab became the world’s first to be ISO/IEC 17025:2005 INAB ... (cat allergen) analysis. , ISO/IEC 17025:2005 is the globally recognised standard that sets ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... Feb. 27, 2017  A landmark study ... , MBBS, PhD, FRACS, of  Sydney Heart and ... Sydney will be published in the February 28, ... American College of Cardiology . According to the study, which ... bypass surgery technique (anOPCABG) reduced postoperative stroke ...
(Date:2/27/2017)... TAMPA, Fla. , Feb. 27, 2017 ... device company focused on developing cerebral embolic protection ... members of the FDA,s Circulatory System Devices Panel ... of the need for cerebral protection following transcatheter ... statements shared by this FDA panel support the ...
(Date:2/27/2017)... , February 27, 2017 Now ... the pharmaceutical companies that are most successful at developing and ... ... you gave the same molecule to two different companies in ... Based on systematic, objective analysis of each company,s performance ...
Breaking Medicine Technology: