Navigation Links
Oxycontin, Other Opioid Painkillers Tied to Higher Health Risks
Date:12/13/2010

MONDAY, Dec. 13 (HealthDay News) -- Two new studies suggest that Medicare patients who take opioid painkillers such as codeine, Vicodin or Oxycontin face higher health risks, including death, heart problems or fractures, compared to those taking non-opioid analgesics.

However, it's not clear if the painkillers are directly responsible for the differences in risk, experts said, and other factors could play a role. And one pain specialist who's familiar with the findings said they don't reflect the experiences of doctors who've prescribed the drugs.

In one study, researchers examined a database of Medicare recipients in two states who were prescribed one of five kinds of opiod painkillers from 1996-2005. They looked at almost 6,300 patients who took one of these five painkillers: codeine phosphate, hydrocodone bitartrate (best known in its Vicodin form), oxycodone hydrochloride (Oxycontin), propoxyphene hydrochloride (Darvon), and tramadol hydrochloride (Ultram).

Those who took codeine were 1.6 times more likely to have suffered from cardiovascular problems after 180 days, while patients on hydrocodone seemed to be at higher risk of fractures than those who took tramadol and propoxyphene.

After 30 days, those who took oxycodone were 2.4 times more likely to die than those taking hydrocodone, and codeine users were twice as likely to die, although the number of deaths was small.

The study authors caution that their findings are surprising in some ways and need to be confirmed by further research.

Commenting on the study, Dr. Russell K. Portenoy, chairman of the department of pain medicine and palliative care at Beth Israel Medical Center in New York City, said that the findings are of limited value because many other factors could explain the differences between the drugs, such as how fast physicians ramped up the doses of patients.

"I would suggest that readers note this as an observation and wait for the next set of studies to try to figure out if there's any reality in there in terms of risk," he said.

A second study published in the same issue of the journal compared opioid painkillers against non-opioid analgesics, and found that patient "adverse events" were more likely when an opioid was taken.

A team led by Dr. Damiel H. Solomon of Brigham and Women's Hospital, Boston, compared the safety of opioids against non-steroidal anti-inflammatory drugs (NSAIDs, which include aspirin, ibuprofen and naproxen) and "coxib" drugs such as Celebrex (celecoxib). They tracked outcomes for almost 13,000 Medicare recipients who took such pain relievers between 1999 and 2005.

The Boston team found that patients on opioids had higher rates of adverse events generally than did people taking an NSAID or a coxib drug. For example, 101 of every 1,000 prescription opioid users suffered a fracture in a given year versus 19 of every 1,000 people taking another type of painkiller. Coxibs and opioids were also associated with a higher risk for cardiac events compared to NSAID use, the team found.

What to do if you're taking an opioid? "There's no question that opioid drugs carry important risks," Portenoy said. "If you have chronic pain, your doctor should optimize the dosing and be managing the risk: not only the risk of side effects and toxicities but also the risk of things like drug abuse."

More information

There's more on painkillers at the U.S. National Library of Medicine .

-- Randy Dotinga

SOURCE: Russell K. Portenoy, M.D., chairman, department of pain medicine and palliative care, Beth Israel Medical Center; New York City; Dec. 13/27, 2010, Archives of Internal Medicine;


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New York Truck Driver Watching Porn Kills Mother, Appalls Personal Injury Lawyers Such As David Perecman
2. California IVF Discount/Rebate Program Eases Risk for Older Mothers
3. MyDietShopz.com Announces Biggest Losers Contest - Share Your Story To Inspire Others
4. Six Other E. colis Could Be Lurking In Your Valentine Days Dinner
5. Virtual reality and other technologies offer hope
6. Another Study Refutes Vaccination-Autism Link
7. Most Americans Think Its Others Who Are Unhealthy
8. Transitions Championship Announces Strongest Field to Date and a Vision Like No Other on the PGA TOUR(R)
9. 29 Clear Channel stations Nationwide Raise Nearly $2.8 Million to Help Save the Lives of Kids Fighting Cancer and Other Deadly Diseases
10. Split-course palliative radiotherapy confirmed as effective treatment for advanced NSCLC
11. “Hearts and Minds” Education Program Launched: On Average, People with Mental illness Live 25 Years Less than Other Americans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Oxycontin, Other Opioid Painkillers Tied to Higher Health Risks
(Date:9/21/2017)... ... September 21, 2017 , ... ... communities, nine governmental public health departments have been awarded five-year accreditation status through ... that the benefits of being served by a PHAB-accredited health department now ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... using Microscan’s LVS 7510 at the Global GS1 Healthcare Conference 2017 in Chicago, ... the life-sciences industry for ensuring label quality and improving patient safety. , ...
(Date:9/21/2017)... ... 2017 , ... Japanese Zen artist couple, Fumie and Kentaro Mune, have announced ... October at Miranda Kuo Gallery on Lower East Side, NYC. This exhibition will feature ... Wanderlust , one of the largest US yoga online media outlets in the ...
(Date:9/21/2017)... ... September 21, 2017 , ... Sagora Senior Living, one ... at Kingwood Assisted Living and Memory Care located at 24025 Kingwood Place Drive, ... assisted living apartments, 43 memory care apartments and 23 extended care apartments. Modern ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... center in Prescott, Arizona, is now accredited by The Joint Commission for chemical ... organization that accredits and certifies U.S. health care organizations that meet the commission’s ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September 18 ... D.C. offering free MRI brain scans to the public.Where:  ... be parked at 501 K Street NW, Washington, D.C.What:BTF brings its nationwide ...
(Date:9/9/2017)... INDIANAPOLIS , Sept. 9, 2017  Eli Lilly ... key primary and secondary endpoint data for lasmiditan, an ... migraine, which demonstrated statistically significant improvements compared to placebo ... be highlighted today at the 18th Congress of the ... . "The data presented today demonstrate lasmiditan,s ...
(Date:9/7/2017)... , Sept. 7, 2017  For nearly two decades, New Life ... the Assisted Reproduction Insurance industry. Today, New Life Agency announces a powerful ... ... (PRNewsfoto/PharmaCareCard) ... http://pharmacarecard.com/ ...
Breaking Medicine Technology: