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Oxford Nanopore announces licence agreement with Harvard University for graphene DNA sequencing
Date:3/11/2011

containing ionic solutions, and created a hole - a nanopore in the graphene. The group demonstrated that the graphene nanopore could be used as a trans-electrode, measuring a current flowing through the nanopore between two chambers. The trans-electrode was used to measure variations in the current as a single molecule of DNA was passed through the nanopore. This resulted in a characteristic electrical signal that reflected the size and conformation of the DNA molecule.

At one atom thick, graphene is believed to be the thinnest membrane able to separate two liquid compartments from each other. This is an important characteristic for DNA sequencing; a trans-electrode of this thickness would be suitable for the accurate analysis of individual bases on a DNA polymer as it passes through the graphene.

Nanopore techniques aim to improve substantially the cost, power and complexity of DNA sequencing. While first generation technologies in development at Oxford Nanopore use nanopores made by porous proteins, subsequent generations will use synthetic 'solid-state' materials such as silicon nitride. However, at this time challenges remain in industrial fabrication of synthetic nanopores with the required dimensions and electronic properties. Graphene offers a potential solution due to its strength, dimensions, electrical properties and future potential for low-cost manufacturing.


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Contact: Zoe McDougall
media@nanoporetech.com
44-845-034-7900 x2013
Feinstein Kean Healthcare
Source:Eurekalert  

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Oxford Nanopore announces licence agreement with Harvard University for graphene DNA sequencing 
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