Navigation Links
Overweight and obese men have lower PSA values, even before they get prostate cancer
Date:2/19/2008

DURHAM, N.C. -- Men who are overweight or obese have lower concentrations of prostate-specific antigen (PSA) in their blood than their normal-weight counterparts, according to a new study led by Duke University Medical Center researchers.

The finding echoes earlier results on PSA concentrations found in obese and overweight men with prostate cancer and highlights the need to reconsider PSA threshold values for heavier patients, and to encourage those patients to get serious about losing weight.

A study released last year from our group showed that obese and overweight men with prostate cancer had deceptively low PSA scores compared to normal-weight men with prostate cancer, but we now have extended our findings to show that this trend holds true in the general screening population, said Marva Price, R.N., a family nurse practitioner and researcher in Dukes School of Nursing, the Duke Comprehensive Cancer Center and the Duke Prostate Center..

We found that mildly obese mens PSA scores were fourteen percent lower than normal-weight men, and moderately and severely obese men had 29 percent lower PSA values, Price said.

Doctors have proposed that overweight and obese men have lower PSA scores because their bodies have a greater volume of blood. Larger blood volumes dilute the amount of PSA in the bloodstream, making the concentration of PSA -- which is what is measured to screen for prostate cancer -- lower.

The latest results appear online in the Feb. 9, 2008 issue of the journal Urology. The study was funded by the United States Department of Defense.

PSA is considered the gold standard for detecting prostate cancer; it is a protein released into the blood by the prostate gland, and is elevated in the presence of cancer.

For this study, researchers looked at PSA scores among 535 men who took part in a free prostate cancer screening program. Seventy-three percent of the group was overweight or obese.

The prevalence of obesity in the United States has doubled in the past 15 years, Price said. Our study demonstrates yet another health danger that obesity poses. One in three Americans is obese, and a man who is 5'11" and weighs 215 pounds is considered obese.

The best advice clinicians can give their patients is to adopt healthier lifestyles, said Stephen Freedland, M.D., a urologist at Duke and the studys senior author. We tell patients to exercise three or four times a week, eat a healthier diet, high in vegetables and fruits, and keep getting screened, he said. However, to compensate for the lower PSA values, Freedland also recommends lowering the PSA threshold that is considered abnormal for obese men. If we dont do that, we may be missing cancers in obese men, which could lead to delayed diagnosis and poorer outcomes.


'/>"/>

Contact: Lauren Shaftel Williams
lauren.shaftel@duke.edu
919-684-4966
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Overweight people may not know when theyve had enough
2. Overweight Kids Lose Weight Eating Peanuts Every Day in School-Based Study
3. Overweight people more likely to have bad breath, TAU study finds
4. Overweight Twins Battle the Bulge and Gain A New Lease on Life in National Body Challenge: Twins Edition on Discovery Health
5. Overweight Kids Often Become Obese, Unhealthy Adults
6. MetaCure(TM) Launches Investigational Study of Gastric Stimulator for Patients With Type 2 Diabetes Who are Overweight
7. HHS Launches Childhood Overweight and Obesity Prevention Initiative
8. Long-term pharmacotherapy for obesity and overweight: updated meta-analysis
9. Obesity and overweight linked to higher prostate cancer mortality
10. Overweight mothers run greater risk of having hyperactive children
11. Exercise Helps Overweight Youngsters Learn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve their approach ... patient is doing more than filling out a survey; in many cases health professionals ... emphasis in health care and research on the importance of active engagement with patients ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... -- HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy ... team developments today:   ... ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D ...
(Date:9/18/2017)... ALLENTOWN , Pa. and KALAMAZOO, Mich. ... Allentown, Penn. , and OptiMed Specialty Pharmacy ... a business partnership to offer a strategic hub service ... PMD Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, ... A spirometer is a medical device used ...
(Date:9/13/2017)... 2017   OrthoAtlanta has been named the official ... Committee (AFHC) for the 2018 College Football Playoff (CFP) National ... Mercedes-Benz Stadium in Atlanta, Georgia . OrthoAtlanta ... In" campaign, participating in many activities leading up to, and ... ...
Breaking Medicine Technology: