Navigation Links
Overlooked ugly cholesterol causes heart disease
Date:1/21/2013

THE GOOD, THE BAD AND THE UGLY The risk of ischaemic heart disease a disease affecting some 150,000 Danes is three times higher in persons with high levels of the so-called 'ugly' cholesterol. This is the finding of a new study of 73,000 Danes, which is shedding light on a long debate on this topic. The results have just been published in the Journal of the American College of Cardiology.

Most Danes are aware that high cholesterol is life-threatening. But very few know which type of cholesterol is the most frequent killer. Cholesterol is divided into 'the good' HDL cholesterol, 'the bad' LDL cholesterol and 'the ugly' cholesterol. It is the so-called 'ugly cholesterol' also called 'remnant-like particle cholesterol' that is the really bad guy.

"LDL cholesterol or 'the bad' cholesterol' is of course bad, but our new study reveals that the ugly cholesterol is the direct cause of arteriosclerosis (hardening of the arteries) resulting in ischaemic heart disease and early death. By examining 73,000 persons, we found that an increase in the ugly cholesterol triples the risk of ischaemic heart disease, which is caused by lack of oxygen to the heart muscle due to narrowing or blocking of the coronary arteries," says Professor Brge Nordestgaard, chief physician at Herlev Hospital and Clinical Professor at the Faculty of Health Sciences at the University of Copenhagen.

"I hope that this new knowledge will lead to better preventive treatment, as more than one in five Danes suffers from high ugly cholesterol. We also hope that the pharmaceutical industry will develop new drugs targeted specifically at raised ugly cholesterol levels," he emphasises.

Widespread disease worldwide

In Denmark alone, 20,000 persons are diagnosed with ischaemic heart disease every year, and some 150,000 Danes are currently affected by the disease. According to World Health Organization estimates, 17 million people fall victim to cardiovascular disease the most frequent cause of death in the world.

"High ugly cholesterol is the result of high blood levels of normal fat (triglycerides). The most important cause of high ugly cholesterol is overweight and obesity. Persons with high ugly cholesterol should therefore be advised to lose weight, but drugs such as statins and fibrates may also lower levels of ugly cholesterol in the blood," says Brge Nordestgaard.

Samples from 73,000 Danes with genetic defect

Anette Varbo, physician and PhD student at Herlev Hospital, has been part of the research team behind the new findings. She says that the findings shed light on a long-standing debate among researchers on the so-called triglyceride, arteriosclerosis and cholesterol.

"To be able to examine the correlation between ugly cholesterol and heart disease, we have used blood samples from persons having a genetic defect which means that they suffer from high ugly cholesterol their entire life. The research findings do therefore not depend on their lifestyle patterns in general. Unhealthy lifestyle factors such as smoking, fatty foods and overweight all increase the risk of heart disease, and the blood samples from persons having this genetic defect thus give the most accurate results," says Anette Varbo.


'/>"/>

Contact: Brge Nordestgaard
Boerge.Nordestgaard@regionh.dk
45-30-28-72-63
University of Copenhagen
Source:Eurekalert

Related medicine news :

1. Cancer-Related Fatigue Often Overlooked, Study Finds
2. Eczema Non-Profit Seeks To Shine New Light On Overlooked Condition
3. Patient mental health overlooked by physician when a family member is present
4. Smoking, high blood pressure and cholesterol can be fatal for hemorrhage survivors
5. Cholesterol medicine affects energy production in muscles
6. VABC Responds to Study on Use of Cholesterol Lowering Drug Statins on Cancer Patients
7. Statins Plus Exercise Best at Lowering Cholesterol, Study Finds
8. Letter from doctor boosts cholesterol medication use
9. No Need to Fast Before Cholesterol Blood Test: Study
10. New drug significantly lowers bad cholesterol
11. Could Cholesterol Treatment Fight Repeat Heart Attack?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
Breaking Medicine Technology: