Navigation Links
Overlooked Mutation Can Spur HIV Drug Resistance
Date:12/1/2007

It should be added to standard genetic tests used to guide treatment, experts say

SATURDAY, Dec. 1 (HealthDay News) -- One in 10 HIV-infected people receiving drug treatment harbors a hidden genetic mutation that renders certain strains of the virus more resistant to antiretroviral medications, researchers say.

Their study suggests that the N3481 mutation should now be added to standard HIV gene tests that AIDS specialists use as they decide which cocktail of drugs a patient should receive.

"The importance of N3481 is also underscored by the fact that it appears relatively early after starting drug therapy," noted study senior author Gilda Tachedjian, head of the Molecular Interactions Group at the Macfarlane Burnet Institute for Medical Research and Public Health, in Melbourne, Australia.

The mutation, largely overlooked by researchers, appears to confer resistance to zidovudine (AZT or Retrovir), the first drug ever approved to fight HIV; and nevirapine (Viramune), one of a group of powerful antiretroviral medications.

Both medicines fall into a broad category of drugs called reverse transcriptase inhibitors (RTIs), so named because they target a key enzyme on HIV called reverse transcriptase.

Tachedjian's group published its findings late Friday in the December issue of PLoS Medicine on the eve of World AIDS Day.

Gene tests aimed at gauging a particular strain of HIV's resistance to common AIDS drugs are routine in clinical practice, noted Mattias Gotte, an associate professor of microbiology and immunology at McGill University in Montreal. Gotte is also the author of an accompanying commentary in the journal.

"You go as an infected person to a clinician, and you get a certain regimen. Most of the time the clinician uses genotyping [gene tests] to see whether certain preexisting mutations may compromise therapy," he explained. "The other thing that happens is when
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. Gene Mutations May Cause Rare Neonatal Diabetes
2. Gene Mutation Linked to Parkinsons Disease
3. Research shows how genetic mutation causes epilepsy in infants
4. Gene Mutation Key to Infertility in Male Mice
5. Fat on chest and upper back increases risk of insulin resistance
6. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
7. Cell skeleton may hold key to overcoming drug resistance in cancer
8. Genetic approach provides new insight into trastuzumab resistance in breast cancer
9. Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies
10. HIV drug resistance risk in mothers reduced by combination of common drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Overlooked Mutation Can Spur HIV Drug Resistance
(Date:3/27/2015)... Ticket Down is a reputable source of authentic Garth ... on Friday, May 8th and Saturday, May 9th. There ... in Omaha as Garth has done in other markets as ... Tour is continuing its run throughout the United States this ... Yearwood will bring their act to Omaha, NE at the ...
(Date:3/27/2015)... Francisco, CA (PRWEB) March 27, 2015 ... Recovery Yoga for functional fitness athletes. This new program ... a specific protocol for post-workout cool down. This program ... promote breath control and mental focus. , Karen ... “I started practicing yoga long before I started Crossfit® ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 SMI ... today announced it has launched the SM1120 MEMS based ... market. The microsensor profile at only 220um x ... maneuverability to reach challenging locations. With industry leading ... hour, the SM1120 provides a broad operating pressure range ...
(Date:3/27/2015)... Operatic contenders and their avid audience will be in ... acclaimed baritone Sherrill Milnes will be overseeing the grand ... Merion in Evanston. The event is the culmination of ... from around the country. “This is a highly-anticipated yearly ... in the country,” said Margaret Gergen, executive director of ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 The ... Industry is a professional and in-depth study on ... market with a focus on the Chinese ... of the industry including definitions, classifications, applications and ... provided for both the international and Chinese domestic ...
Breaking Medicine News(10 mins):Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 2Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 3Health News:Endure Yoga Introduces WOD Recovery Yoga 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Opera Idol Competition At The Merion In Evanston 2Health News:Glutathione Industry International and China Market Analysis Report 2015-2020 2Health News:Glutathione Industry International and China Market Analysis Report 2015-2020 3
... FOR IMMEDIATE RELEASE , A nano-sensor for better ... , In an advance in food safety, researchers ... sensor that detects record low levels of the deadly ... so-called prion diseases. The sensor, which detects binding of ...
... Suracell,s Italian partner, DNA Research, officially launches Suracell ... international markets expected to open soon, SOUTH ... ), the leading provider of genetically directed,personalized age ... in,a series of worldwide partnerships to bring its ...
... Inc. (Nasdaq: PMTI ), a leading researcher ... today announced that,it has entered into a non-exclusive ... PG ) to exploit home-use light-based hair ... retains a non-exclusive,license in the female market to ...
... process helps make sale of long-term care ... insurance simpler for producers, ... Company (NYSE: PTA ) has developed a new streamlined ... qualify for long-term care insurance (LTCi)., Penn Treaty,s LTCi ...
... a New Jolt with Java, BURLINGAME, Calif., ... helps solve people,s everyday problems by,providing reliable "how ... popular bean by providing interesting facts and alternative,uses ... in March.,HowToDoThings.com has created a Caffeine Resource Guide ...
... March 3 New information about food,and diet appears ... a friend,s personal endorsement of a trendy diet, news ... true, and how do you,separate the truth from the ... National Nutrition Month(R), the American Dietetic Association,urges consumers to ...
Cached Medicine News:Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 2Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 3Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 4Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 5Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 6Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 7Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 8Health News:American Chemical Society's weekly PressPac -- Feb. 27, 2008 9Health News:Anti-Aging/Genetic Health Leader Suracell, Inc. Expands Internationally 2Health News:Palomar Seeks to License Additional Companies to Home-Use Light-Based Hair Removal Technology 2Health News:Palomar Seeks to License Additional Companies to Home-Use Light-Based Hair Removal Technology 3Health News:Palomar Seeks to License Additional Companies to Home-Use Light-Based Hair Removal Technology 4Health News:Penn Treaty Introduces LTCi QuickPass(SM) Program 2Health News:HowToDoThings.com Brews Up New Uses for Coffee That Will Perk You Up in Recognition of March's 'Caffeine Awareness Month' 2Health News:During National Nutrition Month and Beyond, Find the Facts on Nutrition by Focusing on the Science 2
(Date:3/27/2015)... 2015 According to a new ... (Conventional, Advanced, Ultrasound), Ablation Catheter (Cryoablation, RF, Microwave), Lab ... VT, WPW) - Global Forecasts to 2019 ", published by ... around ~$4.73 Billion by 2019 with a CAGR of ... Browse   90   ma ...
(Date:3/27/2015)... DALLAS , March 27, 2015   ... global leader in biosimilars and the world,s leading ... two studies that support an evaluation of biosimilarity ... U.S. Food and Drug Administration (FDA) conditionally approved ... Amgen,s EPOGEN™ (epoetin alfa). These study data were ...
(Date:3/27/2015)... RnRMarketResearch.com adds "Visceral Pain ... report of 52 pages with latest updates, data ... The report "Visceral Pain - Pipeline Review, H1 ... for Visceral Pain, complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ...
Breaking Medicine Technology:Electrophysiology (EP) Market Worth $4.73 Billion by 2019 2Electrophysiology (EP) Market Worth $4.73 Billion by 2019 3Electrophysiology (EP) Market Worth $4.73 Billion by 2019 4Hospira Clinical Data Shows Proposed Biosimilar, Epoetin Hospira, Demonstrates Pharmacokinetic And Pharmacodynamic Equivalence Compared To Amgen's Epogen 2Hospira Clinical Data Shows Proposed Biosimilar, Epoetin Hospira, Demonstrates Pharmacokinetic And Pharmacodynamic Equivalence Compared To Amgen's Epogen 3Visceral Pain Pipeline Review H1 2015 Market Research Report 2Visceral Pain Pipeline Review H1 2015 Market Research Report 3Visceral Pain Pipeline Review H1 2015 Market Research Report 4
... Oramed Pharmaceuticals Inc. (OTCBB: ORMP.OB) ( http://www.oramed.com ), ... that it has received approval for a key patent ... "Methods and Compositions for Oral Administration of Exenatide," covers ... portfolio now consists of three issued patents and 34 ...
... Diagnostics, Inc., a molecular diagnostics company, today announced it ... a meeting sponsor at the upcoming ISPD 16th International ... Fla. (Logo: http://photos.prnewswire.com/prnh/20120326/NY75864LOGO ) ... titled, "Analysis of Maternal Age, Gestational Age and Aneuploidy ...
Cached Medicine Technology:Oramed Pharmaceuticals Granted Core Technology Patent in New Zealand 2Oramed Pharmaceuticals Granted Core Technology Patent in New Zealand 3Ariosa Diagnostics to Present and Exhibit at the 16th International Conference on Prenatal Diagnosis and Therapy 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: