Navigation Links
Overexpression of proteins 14-3-3 related to chemotherapy resistance
Date:6/8/2012

Certain proteins, such as 14-3-3, conserve their basic functions of cell cycle control in diverse organisms, from worms to humans. In a study led by Julin Cern and Sim Schwartz Jr, researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the Research Institute of Vall d'Hebron (VHIR) respectively, have described germ line functions of par-5, which is one of the two 14-3-3 proteins existing in Caenorhabditis elegans, worms used as experimental model in genetic studies. The overexpression of the 14-3-3 proteins is related to the resistance of tumors to chemotherapy, which could have implications for clinical practice.

Researchers found that par-5 gene, as its human homologs, is required for DNA damage response in C. elegans validating the model to investigate chemotherapies and genetic modifications since 14-3-3 proteins are therapeutic targets in cancer. The results of this research have been published in the latest issue of Journal of Cell Science.

The powerful genetic tools of C. elegans have allowed a precise functional dissection of the single 14-3-3 protein present in their germline. The researchers have discovered that par-5 is not only necessary for proper cell cycle regulation, but also to prevent the accumulation of endogenous DNA damage and genomic instability.

Moreover, this study reveals that par-5 is required for DNA repair response when it is damaged by chemicals or ionizing radiation. In such response, the researchers propose a model where PAR-5 regulates CDK-1 phosphorylation to stop the cell cycle and repair the damage induced by chemotherapeutic agents.

The overexpression of the 14-3-3 protein has been related to chemotherapy resistance in cancer cell lines while its downregulation sensitizes cells to therapy-induced cell death. Therefore, this study in C. elegans provides the basis for a model to study chemotherapy response in the context of a whole living organism.

Regulators proteins 14-3-3, evolutionarily conserved, bind to signaling proteins and affect their stability, activity or cellular localization. So, they are involved in the regulation of various cellular processes, including apoptosis, the cell cycle and stress response.

In addition, the researchers found that par-5 is required for cell cycle arrest in response to replicative stress and ionizing radiation.


'/>"/>
Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related medicine news :

1. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
2. Warwick scientists uncover how checkpoint proteins bind chromosomes
3. Fatty acid found in fish prevents age-related vision loss: U of A medical research
4. U.S. Assistance to Africa Cut AIDS-Related Deaths: Study
5. Study finds number of battery-related emergency department visits by children more than doubles
6. Some women may be genetically predisposed to smoking-related hot flashes
7. Everyday fish oil capsule may provide kidney-related benefits
8. Genes Associated With Autism Also Related to Schizophrenia
9. When Does Boxing-Related Head Trauma Become Too Much?
10. UT MD Anderson study finds cancer related pain often undertreated
11. Football-related catastrophic brain injuries on the rise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... ... KICKICO , a protocol built on Ethereum for more transparent ICO and ... funding campaigns. KICKICO developers are testing the platform, which will launch for the public ... through the power of many - has been around for about ten years as ...
(Date:6/25/2017)... ... ... a feel-good lyric music video in Final Cut Pro X with ProLyric from Pixel Film ... the lyrics to any song. ProLyric flies in the text for each section and it ... added modularly for optimal control. ProLyric makes editing any music video or text-based production easier ...
(Date:6/25/2017)... ... 25, 2017 , ... CareSet Labs released the Root NPI Graph today at ... new, greatly improved version of the Doctor Referral teaming dataset commonly available from Medicare. ... subsequently called the the “Doctor Referral Dataset” as released by Medicare and “DocGraph” as ...
(Date:6/24/2017)... ... 24, 2017 , ... Genes Advice, a new company based ... and Texas doctors' offices and clinics. This breakthrough testing is part of the ... the role genes play in determining an individual's tolerance of and reaction to ...
(Date:6/24/2017)... ... June 24, 2017 , ... The weather is heating up ... Home and business owners should be aware that the summer months provide more than ... mechanical locks and keys can be negatively affected from direct exposure to the sun. ...
Breaking Medicine News(10 mins):
(Date:6/3/2017)... -- Eli Lilly and Company (NYSE: LLY ... 3 MONARCH 2 study showed that abemaciclib, a ... with fulvestrant, significantly improved progression-free survival (PFS) compared ... hormone-receptor-positive (HR+), human epidermal growth factor receptor 2-negative ... progressed after endocrine therapy (median PFS, 16.4 vs. ...
(Date:5/30/2017)... Israel , May 30, 2017 DarioHealth Corp. (NASDAQ: ... big data solutions, today announced that it will be presenting at ... at 8:00 AM PT. Erez Raphael , CEO, of DarioHealth ... The conference will be held on June 6th & 7th, 2017 ... companies in the small / micro-cap space. ...
(Date:5/29/2017)... 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... enables the functional selection of stem cells, today provided ... first quarter ended March 31 st , 2017. ... in the first quarter of 2017," said Dr. Shai ... announced the treatment of the first blood cancer patient ...
Breaking Medicine Technology: